Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Account Executive (Dallas, TX)
$85K - $100K *
Elevate your sales career by building lasting client relationships and driving revenue growth. This role focuses on strategic account management, fostering connections, and leveraging a dedicated mark...
2 weeks ago
Case Manager, Registered Nurse (Oncology experience required)
$54K - $155K *
Lead the charge in telephonic case management, collaborating with patients and care teams to support quality healthcare delivery. Use clinical expertise to assess needs, implement strategies, and ensu...
Reposted yesterday
$130K - $155K *
Lead data architecture initiatives by optimizing serverless data pipelines and enhancing analytics capabilities through AWS services like SageMaker and Glue. Collaborate on data lakes and AI integrati...
1 month ago
$120K - $145K *
Transform the interaction of mobile robots with their environments by developing cutting-edge learning-based manipulation systems that enhance reliability and safety in dynamic settings, impacting rea...
Reposted 3 weeks ago
Senior Director, Drug Safety Operations (remote)
$160K - $259K *
Lead the charge in optimizing global drug safety operations, ensuring compliance and excellence in pharmacovigilance. Drive strategic initiatives, manage vendor relationships, and enhance processes to...
1 week ago
$70K - $99K *
Empower patient care by utilizing the nursing process to deliver individualized support. Collaborate with a dedicated team in a fast-paced environment, ensuring excellence in all phases of care from a...
Reposted yesterday
Regional Sales Director - Milwaukee
$180K - $215K *
Transform your career by leading regional sales efforts for a groundbreaking product. Drive performance, build a high-performing team, and engage with key healthcare providers in a fast-paced, entrepr...
1 week ago
$150K - $175K *
Transform your career by partnering with business teams in a dynamic legal environment. Leverage your commercial instincts and regulatory expertise to make an immediate impact across two brands in a f...
2 weeks ago
$170K - $180K *
Transform the sales landscape by leading strategic initiatives that enhance performance management, forecasting, and accountability across the commercial organization, driving profitable growth and ac...
3 weeks ago
Senior Counsel - Indirect Procurement
$119K - $186K *
Manage legal services for indirect sourcing, delivering strategic counsel and project management. Negotiate vendor agreements and ensure compliance while collaborating with stakeholders to support bus...
Today
Senior Manager, Clinical Trial Disclosure & Transparency
$132K - $199K *
Join a team that's committed to transparency in clinical trials, ensuring compliance with global disclosure regulations. This role blends operational and strategic tasks, fostering collaboration and q...
2 weeks ago
Customer Success Manager - US (South West)
$90K - $110K *
Champion customer success by driving impactful relationships, ensuring clients maximize platform value through effective training and insights. Collaborate cross-functionally to enhance account growth...
Reposted 2 weeks ago
$110K - $120K *
Shape the future of marketing strategy for a premier industry expo, driving attendance and engagement through innovative campaigns and cross-functional collaboration. Lead a dynamic team to enhance br...
Yesterday
$175K - $200K *
Transform compliance within a dynamic enterprise by designing and overseeing an effective Ethics and Compliance Program that aligns with regulations and promotes enterprise growth. Drive culture and a...
Reposted yesterday
Nationwide- Clinical Psychologist (remote)
$80K - $95K *
Support patient evaluations by conducting psychological assessments and collaborating with a clinical team to enhance diagnostic outcomes and treatment plans. Leverage expertise in standardized testin...
4 weeks ago
$80K - $95K *
Engage with mission-driven organizations to drive growth in housing solutions. Own the full sales lifecycle, from prospecting to closing, while expanding your portfolio and collaborating across teams...
2 days ago
Clinical Documentation Manager
$111K *
Unlock potential by leading Clinical Documentation Integrity operations, enhancing physician engagement, and driving performance improvement. Collaborate with diverse teams to ensure compliance and op...
3 weeks ago
Senior Security Engineer, DeFi
$150K - $180K *
Explore opportunities as a Senior Security Engineer, safeguarding the DeFi ecosystem by identifying vulnerabilities, enhancing monitoring tools, and ensuring compliance with security protocols. Collab...
Reposted 4 weeks ago
Lab Point of Care Sales Specialist
$100K - $115K *
Unlock potential by providing vital sales support and presentations, driving customer integration and product utilization, while conducting market research to enhance offerings. Collaborate closely wi...
Reposted 1 week ago
Senior Staff Frontend Engineer
$150K - $180K *
Join us to architect a unified web platform that enhances user experience across multiple services. Lead front-end development, optimize performance, and mentor engineers while ensuring seamless integ...
2 days ago
$133K - $147K *
Help us guide financial institutions to measurable outcomes through expert value consulting. Leverage your analytical skills and industry knowledge to influence engagement, optimize platform usage, an...
Reposted 4 weeks ago
Senior Implementation Project Manager
$110K - $130K *
Manage implementation projects, ensuring clear ownership and accountability across complex customer engagements while maintaining rigorous oversight of critical paths and deliverables for timely launc...
Reposted 4 weeks ago
National Account Manager - Tile Retail
$75K - $90K *
Take ownership of national account strategies, driving sales growth and fostering relationships with key retail partners. Lead product initiatives and collaborate with cross-functional teams to enhanc...
3 days ago
$130K - $160K *
Drive the development of LLM-based agents, ensuring robust production systems, effective evaluation, and seamless integration with company data while maintaining security and operational excellence ac...
3 weeks ago
Management Analyst (Human Resources)
$80K - $95K *
Help us enhance federal human capital operations through independent analysis, strategic recommendations, and effective program delivery. Collaborate on data-driven insights to improve efficiency and...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.