Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Lead Application Support Analyst - Health Plan
$67K - $108K *
Join a team that's dedicated to enhancing healthcare through innovative technology solutions. Lead projects, collaborate with stakeholders, and ensure optimal application use while mentoring team memb...
Reposted 2 days ago
Senior Payment Accuracy Specialist (Healthcare)
$78K - $83K *
Shape the future of audit excellence by developing innovative concepts, mentoring teams, and ensuring quality control. Drive client satisfaction and enhance audit productivity through strategic oversi...
2 days ago
$130K - $150K *
Advance your career by leading product strategy for supply chain orchestration. Drive technical decisions, collaborate with cross-functional teams, and leverage AI to enhance workflows, ensuring measu...
2 weeks ago
Director, Strategic Growth & Operations
$150K - $200K *
Empower strategic growth and operations by integrating cross-functional teams, aligning priorities, and driving initiatives to enhance study delivery and operational excellence in a dynamic environmen...
Today
$215K - $240K *
Shape the future of commercial operations by leading strategy, workflows, and data integration. Collaborate with senior leaders to enhance brand performance and drive operational excellence across cro...
2 weeks ago
Associate Vice President, Clinical Services - Market Access Marketing
$180K - $220K *
Champion clinical services initiatives, driving strategic content development and mentoring teams to enhance market access and client success. Lead projects, ensure compliance with standards, and reso...
Reposted 3 weeks ago
Director, Commercial Planning & Excellence
$170K - $180K *
Lead the strategic execution of commercial planning and sales coverage, aligning cross-functional teams to drive profitable growth. Oversee territory design, customer segmentation, and annual planning...
3 weeks ago
$85K - $100K *
Help us optimize Epic applications by leading projects, troubleshooting issues, and ensuring seamless integration. Collaborate with teams to enhance workflows and provide expert support, all while mai...
1 week ago
Enterprise Account Executive, Home-Based Care Sales
$128K - $150K *
Help us drive growth in the Home Health and Pediatric Care sectors by generating new enterprise revenue. Own the full sales cycle, engage decision-makers, and develop strategic relationships to establ...
Reposted 3 weeks ago
$120K - $145K *
Join a dynamic Reliability team as a Senior Database Engineer, enhancing database performance and reliability. Collaborate across engineering to optimize distributed databases, ensuring high availabil...
3 weeks ago
$78K - $108K *
Empower our growth by managing and negotiating sales contracts, collaborating with cross-functional teams to ensure compliance and efficiency. Your expertise will drive impactful solutions in a dynami...
Today
$130K - $192K *
Join a team that's implementing robust security controls across multiple brands, safeguarding employees and enhancing productivity through automation and secure practices. Collaborate globally while l...
Reposted 1 week ago
Senior Consultant - Healthcare Compliance
$100K - $125K *
Empower healthcare compliance by enhancing programs, mitigating risks, and driving operational integrity. Collaborate with diverse clients to deliver tailored solutions in a dynamic regulatory landsca...
3 weeks ago
Government Contract Specialist - Risk Mitigation
$108K - $181K *
Transform contract management by leading risk mitigation strategies and ensuring compliance across government and commercial projects. Drive operational excellence and enhance proposal quality while m...
3 weeks ago
$80K - $95K *
Champion operational excellence by overseeing regional profitability, managing staffing efficiencies, and driving performance improvements. Collaborate with management to achieve financial goals and e...
Today
$140K - $160K *
Transform AI analytics by executing measurement frameworks and optimizing performance across voice and chat channels. Collaborate with cross-functional teams to deliver actionable insights and enhance...
2 weeks ago
$110K - $130K *
Elevate your career by collaborating with cross-functional teams to enhance business operations, streamline processes, and drive value through effective analysis and documentation. Your expertise will...
2 weeks ago
$71K - $100K *
Drive strategic initiatives by analyzing market trends and performance metrics. Collaborate with cross-functional teams to develop business cases and forecasts, ensuring data integrity and delivering...
1 week ago
$100K - $120K *
Innovate your career by building agile marketing systems that leverage AI and data. Own the demand generation engine, connecting audience insights and multi-channel campaigns to drive measurable growt...
2 weeks ago
Attorney - Commercial Contracts
$150K - $170K *
Support our Legal team by managing the contract lifecycle, drafting agreements, and ensuring compliance. Collaborate with the Supply team to enhance contracting processes and infrastructure in a fast...
1 week ago
$300K *
Manage the complete sales cycle by identifying leads, building relationships, and closing deals efficiently while collaborating with cross-functional teams to enhance customer success and drive the ad...
Reposted 4 weeks ago
Senior Director, Patient Recruitment - Remote
$150K - $180K *
Inspire patient recruitment strategies by leading a dynamic team, collaborating with senior management, and leveraging innovative tools to enhance enrollment across clinical trials while ensuring dive...
1 week ago
Counsel, Regulatory (Pharmacy)
$120K - $145K *
Join a dynamic Legal team to provide actionable regulatory advice across pharmacy laws, impacting healthcare and e-commerce. Collaborate with diverse business units to navigate complex legal landscape...
Today
$150K - $220K *
Oversee a specialized team to ensure AI safety in biological research, addressing dual-use risks and providing expert guidance on complex cases while mentoring junior specialists and advising clients...
3 days ago
IOM Technologist-Traveler East Coast
$80K - $95K *
Champion patient safety by monitoring neuromuscular function during surgeries. Collaborate with surgical teams to ensure optimal outcomes through real-time data analysis and communication, making a si...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.