Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

Sort By: Relevance

$210K - $250K *

Lead strategic business development initiatives, driving deal execution and relationship management with senior health plan stakeholders. Shape growth strategies and negotiate value-based care contrac...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$72K - $120K *

Lead a multi-disciplinary team in developing machine learning algorithms to enhance clinical decision support, leveraging healthcare datasets for innovation and making vital discoveries that drive pro...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's shaping intuitive AI experiences through user-centered design. Collaborate with cross-functional teams to translate complex AI capabilities into accessible solutions that drive busi...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$101K - $126K *

Drive the development and execution of clinical programs, ensuring effective support, education, and coordination across departments while managing health outcomes and utilization data for continuous...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Oversee a portfolio of clinical studies, ensuring compliance and quality. Lead Project Managers in executing complex trials, driving operational efficiency and client satisfaction while leveraging you...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Shape the future of cyber claims management by leading a dynamic team, driving strategic initiatives, and ensuring exceptional service delivery while adhering to industry standards and regulatory requ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Empower business success by collaborating with cross-functional teams to enhance operations, gather requirements, and implement IT solutions that align with strategic goals. Drive improvements in orde...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$126K - $154K *

Unlock your potential as a Senior Accountant, driving financial accuracy and compliance. Collaborate across teams to enhance systems, oversee key accounting functions, and support audits in a dynamic...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$68K - $93K *

Join a team that's dedicated to driving sales and enhancing customer relationships in the veterinary sector. Utilize innovative strategies and digital tools to maximize performance and deliver excepti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$275K - $350K *

Lead the charge in transforming operations by integrating AI and technology to enhance member and clinician experiences, ensuring efficient care delivery and operational excellence across a distribute...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$129K - $231K *

Elevate nonclinical toxicology operations by managing study execution, ensuring compliance, and fostering collaboration across teams to advance innovative therapies for sleep-wake disorders. Drive acc...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $115K *

Analyze and enhance client data reporting, driving insights and trends to support customer satisfaction and business growth. Collaborate with cross-functional teams to ensure data integrity and delive...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $108K *

Optimize collaboration and data governance by managing Microsoft 365 services, focusing on SharePoint Online and data protection. Partner with teams to enhance compliance, security, and operational ef...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Transform your career by driving strategic partnerships in healthcare. Leverage your extensive relationships within benefits consulting to influence and expand business opportunities while collaborati...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$110K - $130K *

Join a team that's dedicated to driving growth in healthcare accounts. Leverage your strategic sales expertise to build relationships, identify opportunities, and deliver value in a fast-paced environ...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$89K - $121K *

Shape the future of data-driven decision-making by leveraging diverse technologies to enhance business insights and process automation. Collaborate with stakeholders to deliver impactful solutions wit...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$190K - $230K *

Lead the accounting and financial reporting functions within a growing healthcare organization. Drive integrity across multiple entities, ensure compliance, and strategize cash management while suppor...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Healthcare

$80K - $95K *

Drive quality assurance excellence by leading the development of scalable processes that enhance student recruitment and enrollment, ensuring compliance and continuous improvement across all interacti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Build strong relationships and drive sales for advanced wound care products in a defined territory. Achieve revenue targets through strategic planning, customer engagement, and exceptional service in...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$205K - $256K *

Transform your career by leading Apollo's data strategy, ensuring the highest quality B2B data for GTM success. Drive product vision, collaborate cross-functionally, and enhance customer experiences t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Drive customer satisfaction and growth by nurturing relationships, identifying upsell opportunities, and collaborating on account strategies. Leverage industry insights to maximize account potential a...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$188K - $282K *

Drive the architecture for customer data integration across digital platforms, ensuring secure ingestion and transformation. Collaborate with cross-functional teams to create scalable solutions that e...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$135K - $196K *

Unlock potential by shaping the demo experience through innovative tooling and infrastructure. Collaborate across teams to enhance product communication and drive secure access solutions, all while le...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$200K - $300K *

Drive product strategy and lifecycle management, ensuring alignment with market needs and business growth. Lead cross-functional teams to develop, launch, and support innovative medical devices while...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.