Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager Medical Economics - QuickBase Developer
$82K - $182K *
Develop and maintain QuickBase applications while leading complex analytics projects. Ensure data integrity and support clinical performance reporting. Collaborate with stakeholders to drive continuou...
1 week ago
$110K - $130K *
Drive your career forward by enhancing security systems that protect our workforce and cloud services. Own identity controls, endpoint security, and incident response while building automation for sca...
Yesterday
Medical Director - Inpatient Review
$223K - $313K *
Collaborate with a dedicated team of physicians to ensure high-quality inpatient care through clinical expertise, thorough reviews, and utilization management. Advance patient outcomes by utilizing st...
Reposted 3 weeks ago
Shreveport, LA based Clinical Specialist - Remote, USA
$100K - $140K *
Grow your career with a dynamic role in clinical support, training surgical teams, and ensuring optimal patient outcomes in complex procedures. Collaborate closely with medical professionals, manage i...
Reposted 2 days ago
Global Dx Clinical Pathologist
$106K - $172K *
Elevate veterinary care by interpreting digital cytology and hematology cases. Collaborate with veterinarians, ensure quality control, and contribute to outreach efforts while maintaining high standar...
1 week ago
Associate Director - Clinical Operations - Healthcare
$155K - $259K *
Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...
3 days ago
Sr. Associate Actuary - Healthcare
$120K - $140K *
Elevate healthcare consulting by leading complex actuarial projects, developing financial models, and advising clients on policy impacts. Collaborate with teams to analyze data, mentor analysts, and e...
1 week ago
Clinical Documentation Manager
$73K - $115K *
Unlock the potential of clinical documentation integrity by driving ICD-10-CM coding accuracy and enhancing provider education. Collaborate with cross-functional teams to support risk adjustment initi...
1 week ago
$198K - $297K *
Engage in a dynamic role that empowers team collaboration and drives results in a leading organization recognized for innovation and excellence in performance, fostering an environment of growth and p...
Reposted 2 weeks ago
$188K - $245K *
Elevate your career by leading UX design initiatives that impact user experiences, driving innovation and advocating for design excellence across cross-functional teams in a dynamic environment. Join...
4 weeks ago
Customer Development Specialist - North Central
$68K - $93K *
Unlock your potential as you drive sales and build relationships in the veterinary sector. Utilize digital tools and strategic planning to enhance customer experiences and achieve sales targets in a d...
1 week ago
Group Account Director (Medical Affairs)
$165K - $185K *
Join a team that's shaping strategic direction and driving growth across multi-account projects in medical affairs. In this senior leadership role, you'll enhance client relationships, develop teams...
Reposted 1 week ago
Director, Head of Patient Recruitment and Retention, Americas
$171K - $231K *
Drive innovative patient recruitment strategies to enhance clinical trial enrollment and retention. Collaborate with cross-functional teams to implement data-driven approaches, optimize patient engage...
Reposted 4 weeks ago
Senior Manager Medical Economics
$82K - $182K *
Analyze healthcare costs and quality outcomes to drive value-based care strategies, collaborating with clinical and financial teams. Lead data-driven insights and financial modeling to enhance operati...
Reposted 2 days ago
$91K - $115K *
Transform the candidate experience by sourcing top talent for sales and corporate roles. Collaborate with recruiters and hiring managers to build pipelines, utilizing advanced sourcing techniques and...
3 days ago
Transaction Management Director - Healthcare
$175K - $220K *
Shape the future of healthcare real estate by leading a dynamic transaction management team. Oversee negotiations, staff development, and strategic planning to drive client success and enhance operati...
6 days ago
$79K - $127K *
Drive your career forward by overseeing tax compliance and accounting functions. You'll conduct research, manage filings, and identify opportunities while ensuring adherence to evolving tax laws. Join...
3 weeks ago
Director of Market Development & Referral Strategy
$110K - $130K *
Lead the charge in developing referral growth and market strategies across multiple states. Drive sustainable growth by optimizing processes, leveraging CRM systems, and building high-performing teams...
2 days ago
$420K - $476K *
Elevate your career by driving Employer Sales growth, shaping go-to-market strategies, and building a high-performing sales organization. This strategic role requires strong leadership and expertise i...
Reposted 3 weeks ago
Senior Product Manager - Payments
$137K - $186K *
Join our dynamic FinTech team as a Senior Product Manager, leading strategy, and execution to shape payment solutions. Leverage your product management expertise to drive growth and enhance customer e...
Reposted 1 week ago
Principal, Data Governance Platforms
$149K - $224K *
Shape the future of data governance by leading the design and implementation of enterprise platforms that ensure data integrity, quality, and compliance across the organization, while collaborating wi...
2 weeks ago
Laboratory Sales Specialist | Enterprise Lab
$71K - $118K *
Accelerate progress at client relationships by driving sales growth, consulting on laboratory services, and exceeding targets to enhance patient care. Collaborate effectively with stakeholders while m...
Reposted 1 month ago
Project Lead, Client Onboarding (Remote)
$88K - $105K *
Manage the end-to-end onboarding of healthcare clients, leading cross-functional teams to ensure smooth transitions into coding and billing services while driving operational improvements and maintain...
1 week ago
Northern VA Inova Float Pool - CRNA
$291K *
Engage with a dynamic team as a CRNA in a floating role, providing regional anesthesia across multiple facilities. Enjoy autonomy, diverse cases, and a supportive environment with competitive compensa...
1 week ago
$80K - $95K *
Drive data integrity and operational excellence by resolving complex payer data issues, collaborating across teams, and enhancing data quality for value-based care initiatives. Play a key role in opti...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.