Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$108K - $162K *
Champion customer support by managing maintenance services and operations. Lead a team to ensure timely resolutions and enhance product performance while utilizing technical expertise and strategic pl...
2 weeks ago
$110K - $130K *
Elevate client relationships by leading Client Success teams to ensure operational excellence, proactive issue resolution, and strategic growth, while fostering collaboration across departments to enh...
2 weeks ago
Staff Product Designer, Judiciary.
$150K - $225K *
Drive innovative design solutions as a Staff Product Designer, leading strategy and experience design for a new judiciary product. Collaborate with cross-functional teams to create impactful user expe...
2 weeks ago
Associate Director, Principal Partnerships
$110K - $170K *
Lead the charge in managing strategic partnerships, leveraging data insights to drive growth and retention. Collaborate cross-functionally to enhance partner performance and operational excellence whi...
3 weeks ago
Account Specialist (Shreveport, LA)
$160K - $192K *
Empower your career by driving commercial success as you engage healthcare providers, build relationships, and support innovative therapies in a dynamic, remote role focused on impactful patient outco...
1 week ago
$105K - $120K *
Help us drive sales growth and enhance community partnerships by leading a dynamic sales team focused on expanding market share and improving patient registrations in the healthcare sector...
Yesterday
$76K - $96K *
Empower patient care by joining our dedicated nursing team, where you'll provide compassionate, quality care in a fast-paced environment. Collaborate with healthcare professionals to enhance patient o...
6 days ago
$110K - $130K *
Shape the future of secure software development by integrating security practices into engineering workflows, building automation tools, and conducting penetration tests to identify vulnerabilities an...
1 week ago
$110K - $166K *
Lead the charge in managing site contract negotiations and agreements, ensuring alignment with clinical study timelines. Collaborate with cross-functional teams to enhance contract processes and mento...
Yesterday
Senior Data Analyst, Enterprise
$122K - $171K *
Unlock potential by driving data-driven insights for Customer Success. Collaborate across teams to enhance customer journeys, optimize growth strategies, and shape analytics foundations that support A...
6 days ago
$80K - $95K *
Drive client success by managing relationships, optimizing collections, and resolving issues. Collaborate with diverse stakeholders to ensure satisfaction and compliance while leading a team to enhanc...
1 week ago
$90K - $110K *
Manage patient interactions and eye care procedures while fostering lasting relationships and promoting professional development. Ensure comprehensive eye health through education, diagnosis, and trea...
Reposted 3 weeks ago
Medical Director - Critical Care
$300K - $309K *
Transform patient care by leading medical strategy and clinical innovation. As a vital member of the team, you'll guide product development and trial execution while engaging with key stakeholders to...
Reposted 3 weeks ago
Behavioral Health Medical Director
$215K - $408K *
Drive medical leadership in quality improvement and utilization management, ensuring effective care delivery and cost containment. Collaborate with clinical teams to enhance patient outcomes and suppo...
Yesterday
$142K - $195K *
Unlock potential by designing secure, enterprise-scale solutions that protect critical data and systems. Collaborate with stakeholders to assess threats, innovate security architecture, and enhance en...
Reposted 4 weeks ago
Ambulatory Client Sales Executive
$100K - $120K *
Serve as the primary contact for clients, driving engagement and service quality while fostering relationships with key stakeholders and leveraging expertise to enhance organizational growth and clien...
Reposted 2 weeks ago
$115K - $140K *
Join a team that's shaping compelling narratives across diverse marketing channels. You'll craft engaging copy for digital ads, emails, and more, collaborating closely with various departments to enha...
1 week ago
Senior Scientific Director, Neurodegenerative Diseases
$265K - $300K *
Shape the future of neurodegenerative disease diagnostics by leading scientific strategy, driving research programs, and building expert networks to establish industry leadership in innovative solutio...
1 month ago
Applications Analyst- Epic Professional Billing
$67K - $111K *
Elevate your career by providing critical analysis and programming support for application software, ensuring a comprehensive and integrated information network that meets diverse customer needs and e...
2 days ago
Frontend Developer, Device Security
$123K - $172K *
Build and maintain user-friendly administrative interfaces for enterprise customers, enhancing device security management. Collaborate with cross-functional teams to develop scalable solutions and con...
1 week ago
$73K - $91K *
Lead compassionate patient care as a Registered Nurse, utilizing clinical expertise and teamwork to improve health outcomes. Engage with interdisciplinary teams to provide holistic support and quality...
1 month ago
National Director, Integrated Specialty Practices
$160K - $200K *
Drive strategic growth and business development for National Accounts in Urology and Oncology, optimizing resources and leading negotiations to enhance healthcare outcomes through innovative diagnosti...
3 weeks ago
$80K - $95K *
Drive innovative design solutions that elevate brand identity across diverse media. Collaborate with cross-functional teams to create impactful visual assets, ensuring consistency and clarity in commu...
2 weeks ago
Mid-Market Account Executive - MOLAT
$80K - $95K *
Drive new business growth by owning the full sales cycle in the mid-market segment. Leverage your expertise in cybersecurity solutions to maximize revenue and collaborate cross-functionally to achieve...
Reposted 1 week ago
Complex Claims Advisor | Dedicated Client | East Coast States
$90K - $100K *
Unlock potential by managing complex claims with a focus on legal inquiries and resolutions. Collaborate with clients and experts to deliver innovative solutions while enjoying flexibility and profess...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.