Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Category Manager - Professional Services
$113K - $135K *
Innovate sourcing strategies and manage vendor relationships to optimize talent procurement services across various categories, ensuring alignment with business needs while enhancing cost efficiency a...
Reposted 3 weeks ago
$160K - $190K *
Elevate healthcare solutions by transforming complex data needs into scalable systems. Collaborate with cross-functional teams to design and build data pipelines and insightful dashboards that enhance...
Reposted 2 weeks ago
Digital Delivery Implementation Manager
$84K - $114K *
Lead a dynamic team in delivering high-quality digital implementations, driving strategy and process improvements while ensuring customer satisfaction and operational excellence in a fast-paced enviro...
Reposted 1 week ago
Endpoint Engineer I (JAMF & Mac Experience required)
$80K - $100K *
Take ownership of complex desktop and mobile device support, ensuring high customer satisfaction. Administer enterprise management platforms and collaborate with teams to deliver effective technology...
1 week ago
Endpoint Engineer I (JAMF & Mac Experience required)
$80K - $100K *
Transform endpoint management by leading complex support initiatives, ensuring seamless service delivery across diverse environments. Collaborate with teams to enhance user experience and optimize tec...
1 week ago
$120K - $150K *
Lead the charge in delivering complex integrations for clients, embedding with their teams to build reusable assets against our API. Transform vague requests into actionable plans while enhancing depl...
3 weeks ago
Senior Scientific Director - Oncology (Medical Affairs & Commercial Medical Education)
$160K - $190K *
Champion the development and oversight of scientific content across diverse therapeutic areas while managing client relationships and brand strategy for multiple accounts, ensuring high-quality and im...
Reposted 3 weeks ago
$90K - $120K *
Transform patient care by delivering precise teleradiology interpretations across various shifts, utilizing AI tools to enhance workflow and maintain high-quality standards while collaborating with he...
2 weeks ago
Senior Manager, Physical Therapy
$110K - $130K *
Lead the charge in optimizing physical therapy operations, enhancing care quality and access through strategic resource allocation and team development. Collaborate across clinical functions to drive...
2 days ago
Medical Director, Post Acute Care
$207K - $346K *
Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...
Reposted 3 days ago
Manager, Provider Operations - Provider Data
$73K - $115K *
Help us drive operational excellence in provider data management, ensuring accuracy and efficiency throughout the lifecycle. Collaborate with teams to enhance processes, leverage insights, and impleme...
3 days ago
In-Home Traveler Nurse Practitioner or Physician Assistant Full Time - DE
$87K - $187K *
Explore a rewarding role providing in-home health evaluations, fostering relationships to enhance patient care. Travel extensively to deliver personalized health services, ensuring comprehensive suppo...
3 weeks ago
VP, Sales - Health Services and Technology
$180K - $220K *
Engage with healthcare services and technology leaders to drive new business growth. Leverage a robust support system to build relationships, execute territory plans, and expand existing accounts whil...
1 week ago
Clinical Director, Clinical Development
$221K - $335K *
Elevate clinical research by leading innovative studies, ensuring data integrity and patient safety. Collaborate cross-functionally to drive strategic initiatives and enhance clinical development whil...
Today
eDiscovery Analyst, Enterprise Accounts
$100K - $120K *
Champion the management and execution of complex e-discovery projects, collaborating with legal teams to ensure successful outcomes. Oversee multiple projects while mentoring a team, maintaining quali...
2 weeks ago
$126K - $189K *
Join a team that's leading provider enrollment operations, ensuring timely onboarding, compliance, and accuracy. Drive strategic initiatives and enhance operational efficiency across networks while co...
4 weeks ago
$125K - $150K *
Unlock potential by driving new enterprise sales in cybersecurity. Own the full sales cycle, from prospecting to closing, while expanding existing accounts. Collaborate with teams to deliver tailored...
2 weeks ago
Clinical Applications Specialist, Contrast Media Delivery Solutions
$100K - $150K *
Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...
2 weeks ago
Account Specialist (Wilkes Barre, PA)
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovativ...
1 week ago
$110K - $130K *
Transform claims management by leading strategic initiatives, overseeing operations, and driving continuous improvement across a diverse portfolio, ensuring optimal outcomes and compliance while colla...
3 days ago
Manager, Training & Workflow Optimization
$79K - $94K *
Optimize training and workflow processes by leading program development, mentoring trainers, and collaborating with stakeholders to enhance provider experiences and operational efficiency across Care...
Today
Senior Sales Manager - Remote US
$110K - $130K *
Champion a high-growth sales strategy by developing a results-driven team to achieve revenue targets, expand market presence, and foster strategic client relationships while ensuring continuous improv...
2 weeks ago
Director of Clinical Quality and Outcomes (BCBA-D Preferred)
$110K - $130K *
Innovate clinical quality systems for scalable care delivery, ensuring standards meet payer expectations and driving measurable performance improvements across independent health providers...
Reposted 4 weeks ago
$195K - $217K *
Drive client success by leading strategic initiatives and fostering strong relationships in healthcare technology. Leverage deep domain expertise to enhance outcomes and ensure effective use of soluti...
1 week ago
$110K - $130K *
Transform data into actionable insights by building robust data pipelines, dashboards, and monitoring frameworks. Leverage expertise in Skyline DataMiner to enhance network performance analytics and e...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.