Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Regional Sales Director - Cleveland
$180K - $215K *
Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Leverage strong business acumen and collaborative skills to achieve sale...
1 week ago
Manager, Case Management (LCSW/LMFT)
$90K - $115K *
Champion clinical excellence by leading and mentoring a dynamic ECM team, ensuring comprehensive patient care and adherence to individualized plans, while collaborating effectively with multidisciplin...
Reposted 4 weeks ago
Senior Manager, Customer Success Applications
$156K - $234K *
Join a dynamic team to lead the development of AI-driven customer success platforms, enhancing post-sale experiences through innovative technology and automation, while collaborating closely with engi...
Reposted 4 weeks ago
Senior Applications Analyst - Billing
$123K - $207K *
Elevate enterprise systems by leading design and enhancements, ensuring reliability and usability. Collaborate with cross-functional teams to translate requirements into scalable solutions while drivi...
Yesterday
Senior Scientific Director - Publications (Oncology)
$150K - $180K *
Drive impactful scientific communication by overseeing content development across therapeutic areas, ensuring strategic alignment with client goals while managing a team and collaborating with various...
4 weeks ago
$125K - $160K *
Join a dynamic team as a Sr. Health Benefit Plan Consulting Attorney, leveraging your expertise in healthcare law to navigate complex regulatory issues, support consulting services, and drive complian...
Today
$73K - $91K *
Partner with us to enhance operational efficiency and effectiveness through process analysis, continuous improvement, and expert training in LEAN methodologies, fostering collaboration and problem-sol...
Reposted today
Vice President of Implementation
$297K - $367K *
Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...
3 weeks ago
Account Specialist (Cleveland, OH)
$160K - $192K *
Join a team that's driving commercial success by engaging healthcare providers, building relationships, and supporting innovative therapies. Your expertise will be pivotal in executing business plans...
1 week ago
$135K - $160K *
Elevate our deal desk function by transforming processes into a scalable model. You'll implement AI tools, streamline order forms, and ensure efficient deal structuring while collaborating with cross...
3 weeks ago
$195K - $225K *
Drive security innovation by shaping technical strategies and frameworks that protect sensitive data and systems. Collaborate across teams to embed security practices, mentor engineers, and ensure com...
2 days ago
$95K - $115K *
Empower our finance team by overseeing accounting operations, ensuring compliance, and enhancing financial reporting. Lead month-end close activities and mentor team members in a dynamic, multi-entity...
6 days ago
$186K - $202K *
Pioneer innovative engineering solutions by leading technical strategy and architecture for a growing platform. Collaborate across teams to drive scalable, reliable systems while ensuring alignment wi...
1 week ago
$94K - $107K *
Support and enhance data governance operations by collaborating with teams to implement standards, manage data cataloging, and drive tool adoption, ensuring compliance and effective governance workflo...
3 weeks ago
Head of Fertility Sales & Business Development
$150K - $180K *
Lead national physician engagement and business development for a fertility pharmacy, managing a multi-layered team to drive growth and build executive relationships across clinics and provider networ...
1 week ago
Data Engineer | VA Claims Modernization
$120K - $180K *
Drive the modernization of Veterans Benefits Administration claims processing by designing and optimizing scalable data pipelines and solutions, ensuring efficient data integration and analytics for i...
1 week ago
Senior Manager, Lien Negotiation
$110K - $130K *
Lead the charge in building and managing a lien negotiation function, overseeing complex medical lien resolutions while driving team performance and compliance to maximize client recoveries and stream...
3 weeks ago
$80K - $100K *
Drive innovative palliative care solutions for members with complex needs, providing compassionate, evidence-based support through telehealth. Collaborate with interdisciplinary teams to enhance patie...
3 weeks ago
Director, Patient Access (Travel)
$92K - $125K *
Drive operational excellence in patient access by leading teams, enhancing processes, and fostering collaboration across healthcare facilities. Your leadership will ensure compliance, improve patient...
Today
Senior Account Director (Medical Affairs)
$155K - $175K *
Lead the charge in client partnerships while driving strategic growth and team development. Utilize your expertise to deliver impactful insights and solutions in a fast-paced, evolving environment, en...
Reposted 1 week ago
Account Specialist (Toledo, OH)
$160K - $192K *
Transform healthcare engagement by driving commercial performance and building strong relationships with providers. Collaborate cross-functionally to support product launches and ensure patient access...
6 days ago
$125K - $150K *
Shape the future of security by engineering robust controls for endpoints and email. As a Staff Security Engineer, you'll enhance our security posture, mentor peers, and ensure compliance in a regulat...
3 weeks ago
$115K - $130K *
Unlock potential by driving data analysis and interpreting clinical trial results. Collaborate with stakeholders, ensure statistical integrity, and contribute to innovative methodologies in biostatist...
Reposted 3 weeks ago
$91K - $138K *
Contribute to our growth by driving sales of SaaS solutions to government agencies. Collaborate with partners, build relationships, and exceed sales targets while navigating the complexities of govern...
2 weeks ago
Category Manager - Professional Services
$113K - $135K *
Innovate sourcing strategies and manage vendor relationships to optimize talent procurement services across various categories, ensuring alignment with business needs while enhancing cost efficiency a...
Reposted 3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.