Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Dentist Jobs in Pennsylvania

Sort By: Relevance

$134K - $184K *

Unlock potential by joining a dynamic team focused on radiation oncology, where you'll design treatment plans, collaborate with oncologists, and ensure precise dose delivery while utilizing advanced i...

Washington, PARemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Engage in high-quality legal research to support law firm clients, focusing on intellectual property matters. Utilize advanced research tools to deliver accurate results and synthesize findings into a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$84K - $102K *

Drive sales growth by developing strategies to expand market share in healthcare sectors. Engage with clients, promote products, and resolve reimbursement issues while achieving sales goals and mainta...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Join our team as a Clinical Director to lead and enhance inpatient behavioral health services. Oversee clinical staff, ensure quality care, and promote evidence-based practices in a supportive environ...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Join our Mobile Quality Engineering team to ensure the quality and reliability of iOS applications. Collaborate with cross-functional teams to validate features, troubleshoot issues, and enhance user...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Transform creative vision into impactful strategies, leading teams to deliver exceptional work that meets and anticipates client needs while fostering a positive agency culture and driving professiona...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Transform drug discovery by leading innovative cheminformatics workflows, collaborating with cross-disciplinary teams to enhance decision-making and accelerate scientific advancements in medicinal che...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$235K - $350K *

Transform the future of cyber defense by architecting cutting-edge AI systems that autonomously protect against real-world threats. Lead technical direction, mentor teams, and drive innovation from re...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Information Technology

$179K - $280K *

Tackle complex legal management challenges by leading multi-office operations and enhancing organizational excellence. Drive talent development and operational improvements while ensuring high-quality...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$160K - $200K *

Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Transform cloud infrastructure by leading strategy, team development, and automation. Drive security, reliability, and cost management while collaborating across functions to enhance operational excel...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $120K *

Join a dynamic team as you oversee IT operations, user lifecycle management, and security for a growing organization. This hands-on role allows you to set standards and processes while serving as the...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$208K - $235K *

Innovate and lead the development of scalable cloud solutions, ensuring high engineering standards and strategic architecture. Collaborate with cross-functional teams to translate business needs into...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$207K - $290K *

Elevate your career by leading a dynamic Applied AI team, transforming innovative AI solutions into production-ready systems within a regulated financial environment, while collaborating across depart...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$204K - $327K *

Drive innovative legal solutions as a key partner for AI and product teams, providing comprehensive guidance on regulatory challenges and product development. Collaborate cross-functionally to ensure...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$71K - $120K *

Lead the charge in pediatric nursing excellence by overseeing operations, mentoring staff, and ensuring compliance with care standards. Drive quality improvement initiatives while fostering a compassi...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$128K - $145K *

Support the full life cycle of vendor contracts, from negotiation to execution. Collaborate with stakeholders to manage legal risks and ensure compliance in a fast-paced environment, focusing on healt...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Join our Endocrinology team to provide exceptional patient care in a dynamic outpatient setting. Collaborate with physicians and advanced practice clinicians to manage diverse endocrine disorders and...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Optimize verification strategies and lead hands-on testing to enhance product reliability. Collaborate across engineering disciplines to translate requirements into effective test methods, driving imp...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$160K - $192K *

Engage with healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful relat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion statistical programming excellence in oncology clinical trials. Lead programming activities, collaborate with cross-functional teams, and ensure high-quality deliverables from study start-up...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock potential by leading innovative sales training programs for orthopedic trauma and joint reconstruction, enhancing clinical knowledge and sales skills to drive growth and effectiveness in a dyna...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$190K - $275K *

Join a team that's driving strategic technology alliances to transform integrations into robust commercial partnerships, focusing on co-selling, joint marketing, and stakeholder alignment while leadin...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Advance healthcare solutions by building executive relationships and driving enterprise sales. Lead the sales lifecycle, develop strategic accounts, and leverage modern tools to optimize revenue growt...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Join us to lead strategy and implementation for long-term services and supports, ensuring compliance and enhancing participant experience in a dynamic healthcare environment. Drive impactful partnersh...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.