Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$72K - $116K *

Drive quality assurance initiatives by leading data testing strategies, overseeing validation processes, and guiding technical teams in the healthcare domain. Translate complex data risks into actiona...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$256K - $347K *

Lead the charge in ensuring optimal safety standards for Rare Disease products. Establish pharmacovigilance strategies, oversee safety profiles, and engage cross-functional teams to deliver critical t...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Join us to drive commercial performance by engaging healthcare providers, building relationships, and supporting product launches. Collaborate with cross-functional teams to ensure patient access to i...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$72K - $112K *

Serve as a vital technical support resource in healthcare technology, ensuring system stability and customer satisfaction while managing service requests and collaborating with teams for quick resolut...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Advance commercial legal strategies by providing expert counsel on government contracting and compliance. Support teams across contract lifecycles, promoting effective negotiations and risk management...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $95K *

Join a dynamic team to deliver exceptional client service, manage accounts, and enhance relationships with AmLaw firms. Drive success through proactive communication, issue resolution, and a client-fi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$120K - $140K *

Drive your career forward by leading a dynamic PMO team, overseeing complex projects in healthcare technology. Collaborate cross-functionally to ensure strategic alignment and successful execution of...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Contribute to impactful consulting services in government pricing, leveraging your expertise to guide clients through compliance, data analysis, and strategic initiatives while leading a collaborative...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$153K - $268K *

Join a team that's advancing regulatory strategies for drug substance manufacturing. Lead the charge in selecting and justifying Regulatory Starting Materials, ensuring compliance with global guidelin...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$84K - $135K *

Accelerate your career as you build key relationships and drive sales success in the construction supplies sector, achieving ambitious targets while supporting distributor partners in a dynamic field...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$132K - $161K *

Join a dynamic team as you build and manage strong relationships with business clients, delivering tailored financial solutions and expert guidance to help them achieve their goals and drive success i...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Drive analytical excellence by auditing freight contracts and invoices, ensuring compliance and accuracy. Collaborate with teams to enhance audit processes and mentor junior analysts, contributing to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$160K - $192K *

Transform commercial performance by engaging healthcare providers, driving product adoption, and collaborating with cross-functional teams to ensure patient access to innovative therapies across a def...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$156K - $235K *

Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$85K - $125K *

Contribute to acquiring and managing data partnerships, collaborating with product teams to prioritize and improve dataset quality, while leveraging AI to enhance data processes and achieve business o...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $225K *

Oversee complex industrial construction projects, ensuring safety, quality, and timely completion. Lead multidisciplinary teams, manage contractor performance, and coordinate with stakeholders to achi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead client relationships and drive strategic growth while ensuring high-quality delivery. Collaborate across teams to align marketing efforts with client objectives and mentor account strategists for...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $160K *

Elevate cloud security and reliability by leading DevOps practices across teams. You'll optimize AWS and GCP environments, enhance CI/CD pipelines, and ensure cost-effective engineering tools, driving...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$77K - $106K *

Contribute to high-quality patient care by leading a clinical team, overseeing operations, and ensuring compliance. Empower clinicians through guidance and education while fostering independence in pa...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $150K *

Drive complex federal platform initiatives, enhancing security, compliance, and infrastructure through innovative engineering solutions and cross-functional leadership...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$286K - $326K *

Empower high-performing teams to innovate banking solutions in the cloud. Drive technical strategy, coach engineers, and enhance delivery for a resilient, scalable platform. Foster a culture of contin...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Accelerate account management strategy and execution for premier accounts. Strengthen relationships through planning, product penetration, and high-quality execution while collaborating across teams t...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$245K - $290K *

Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead the charge in transforming Revenue Cycle Management through automation, enhancing efficiency and user experience. Collaborate with cross-functional teams to deliver impactful solutions that strea...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$87K - $108K *

Unlock potential by leading contract negotiations and vendor management to enhance supplier relationships and optimize costs for construction and plant operations. Collaborate with internal teams to d...

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.