Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$93K - $128K *

Lead the charge in optimizing branch operations, ensuring quality patient care, regulatory compliance, and team development while driving business growth and achieving key performance indicators in a...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$149K - $224K *

Lead the charge in shaping digital solutions for perioperative workflows, driving strategy and execution across cross-functional teams to enhance clinical outcomes and operational efficiency in surgic...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Drive the evolution of a comprehensive design system, enhancing user experiences across web and mobile platforms. Collaborate with engineering and product teams to ensure quality, accessibility, and c...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $140K *

Help us drive the adoption of innovative colorectal cancer screening solutions by effectively engaging healthcare providers through education, consultation, and strategic support in your assigned terr...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $185K *

Transform the future of healthcare sourcing by leading strategic initiatives, managing a dedicated team, and driving cost-saving projects across Facilities categories to ensure high-quality service de...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$100K - $120K *

Drive evidence-based healthcare improvements by leading evaluations and strategic analyses. Collaborate with multidisciplinary teams to enhance Military Health System outcomes through expert consultat...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$85K - $97K *

Shape the future of healthcare by conducting clinical case reviews and enhancing product quality for an AI-driven clinical platform. Collaborate with care teams to ensure accurate alert functionality...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $145K *

Help us design and implement billing solutions for law firms, leveraging your accounting expertise and software skills to streamline time entry, invoicing, and collections processes on the Litify plat...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$102K - $164K *

Join a team that's shaping the future of enterprise solutions by leading innovative design and implementation of scalable architectures. Collaborate with stakeholders, define strategy, and ensure adhe...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $235K *

Drive growth by leveraging your consultative sales expertise to engage higher education leaders, aligning their needs with innovative research solutions while managing client relationships and achievi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$140K - $190K *

Empower our sales team by driving strategic growth in key accounts. Leverage your expertise in Enterprise SaaS to navigate complex sales in the Life Sciences sector, fostering partnerships and deliver...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$274K - $371K *

Elevate patient care through innovative clinical strategies in obesity and cardiometabolic development. Collaborate across teams to design and implement late-phase studies, ensuring alignment with glo...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $115K *

Manage the end-to-end onboarding of clients, ensuring exceptional outcomes through strong relationships, effective project management, and data analysis in a fast-paced, high-growth environment...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Elevate market presence by driving adoption of innovative cardiac imaging solutions. Collaborate with healthcare professionals to enhance patient care, achieve sales targets, and optimize business str...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$150K - $250K *

Shape the future of compliance at our dynamic organization while driving risk oversight, managing external relationships, and guiding teams to meet complex regulatory requirements across insurance ope...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Finance & Insurance

$175K - $400K *

Elevate your career by managing the lifecycle of vendor agreements and contracts. Collaborate across departments to ensure compliance and streamline workflows, safeguarding business interests while mi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Champion financial excellence by optimizing NetSuite for seamless integrations, customizations, and robust forecasting. Drive efficiency and accuracy in financial processes while owning the technical...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$70K - $100K *

Join a team that's committed to financial excellence, ensuring accuracy and compliance in accounting operations. Lead month-end closes, enhance reporting, and drive process improvements while mentorin...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $100K *

Join our dynamic team as a Technical Delivery Manager, overseeing AI-driven project delivery across diverse digital platforms. Ensure timely, high-quality outputs while leveraging innovative technolog...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $210K *

Partner with us to drive innovative financial solutions in the healthcare sector. Leverage your Workday expertise for impactful implementations, collaborating closely with teams to transform operation...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$66K - $189K *

Innovate analytical strategies to enhance toxicology assessments, ensuring compliance and data integrity. Collaborate across teams to drive project success and influence decision-making through advanc...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Empower enterprise clients by managing complex relationships and driving growth. Leverage your expertise to deliver high-impact solutions, ensuring clients achieve measurable outcomes while expanding...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $130K *

Shape the future of mental health care by providing virtual counseling and developing treatment plans for patients with acute conditions. Collaborate with medical professionals while ensuring adherenc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$200K - $215K *

Drive the design and deployment of innovative data and AI solutions, leveraging expertise in LLMs, agentic AI, and cloud technologies to enhance business value and ensure compliance with industry stan...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by cultivating strategic relationships with benefits consultants and brokers. Drive revenue growth through effective partnerships, collaboration with cross-functional teams, and exper...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.