Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager, Clinical Operations Programs
$160K - $190K *
Join a team that's driving excellence in clinical operations, leading global studies and ensuring regulatory compliance. Utilize your project management expertise to enhance efficiency and maintain hi...
Reposted 3 days ago
$148K - $256K *
Shape the future of data engineering by architecting scalable, cloud-native data platforms on Azure and Databricks. Influence the organization’s data practices to leverage AI-driven insights, driving...
Reposted 2 weeks ago
Remote Medical Review Officer / Paramedic
$80K - $95K *
Transform healthcare outcomes by leveraging clinical expertise to review medical records, ensuring compliance with government standards while fostering collaboration and maintaining confidentiality in...
1 week ago
$174K - $374K *
Unlock potential by leading medical management initiatives remotely, supporting member needs and optimizing clinical services for optimal care. Leverage your expertise in Orthopedic Spine or Neurosurg...
Reposted 1 week ago
$110K - $130K *
Manage and lead field-based medical teams, ensuring client delivery and team performance while fostering scientific engagement and program growth. Collaborate with cross-functional teams to achieve st...
3 weeks ago
Executive Director, HEOR Modeling
$175K - $210K *
Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...
Yesterday
$125K - $150K *
Shape the future of orthodontics by delivering exceptional care and innovative treatments. Join a dedicated team in a thriving practice, enhancing smiles and patient experiences across multiple locati...
3 weeks ago
$239K - $260K *
Join a team that's dedicated to providing comprehensive pediatric care, collaborating with staff to enhance patient experiences, and leading preventive health initiatives in a community-focused enviro...
4 weeks ago
Specialty Development Executive - Northeast Territory
$130K - $140K *
Accelerate the growth of colorectal cancer screening solutions by engaging healthcare providers and driving product adoption. Collaborate with partners while strategically planning to maximize market...
Reposted 2 weeks ago
Physician Assistant or Nurse Practition | Family Medicine
$85K - $100K *
Join a team that's dedicated to providing comprehensive medical care by assessing, diagnosing, and treating patients while promoting health education and collaboration with physicians to enhance patie...
1 week ago
$85K - $100K *
Transform healthcare analytics by supporting ACOs in the MSSP program. Leverage data-driven insights to track performance metrics, optimize risk scores, and collaborate with teams to enhance value-bas...
1 week ago
Regional Sales Director - Cleveland
$180K - $215K *
Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Leverage strong business acumen and collaborative skills to achieve sale...
1 week ago
$180K - $235K *
Drive growth by leveraging your consultative sales expertise to engage higher education leaders, aligning their needs with innovative research solutions while managing client relationships and achievi...
2 weeks ago
Senior Director, Counsel, Diagnostics & Medical Devices
$199K - $321K *
Join a dynamic team to provide strategic legal counsel on diagnostics and medical devices, ensuring compliance with FDA regulations and commercial strategies while collaborating across business units...
1 week ago
Advanced Practice Provider - General & Bariatric Surgery
$90K - $110K *
Manage patient care under physician supervision, focusing on complex cases and collaborating with healthcare teams to ensure optimal outcomes and continuity of care...
6 days ago
$75K - $90K *
Empower patients to achieve optimal physical health by evaluating needs, creating tailored care plans, and delivering effective treatments. Collaborate with a dedicated team to enhance patient outcome...
3 weeks ago
Group Account Director (Medical Affairs)
$165K - $185K *
Join a team that's shaping strategic direction and driving growth across multi-account projects in medical affairs. In this senior leadership role, you'll enhance client relationships, develop teams...
Reposted 1 week ago
Senior Manager, Key Accounts (Providers)
$120K - $140K *
Empower provider accounts post-launch by driving growth through strategic engagement, tailored training, and effective collaboration with internal teams. Cultivate relationships across diverse healthc...
2 weeks ago
RN - Surgery Supervisor: OBGYN Service Line
$87K - $131K *
Join a team that's dedicated to delivering exceptional patient care while overseeing nursing staff and collaborating with healthcare professionals to enhance service quality and operational efficiency...
Yesterday
Obstructive Sleep Apnea Clinical Manager
$120K - $140K *
Transform patient care by leading a team of Field Clinical Specialists, ensuring high-quality clinical education and support. Drive clinical outcomes through effective management, collaboration, and c...
2 weeks ago
Senior Manager, Clinical Conduct
$90K - $110K *
Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...
1 week ago
Medical Director, Post Acute Care
$207K - $346K *
Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...
Reposted 3 days ago
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
3 weeks ago
$90K - $110K *
Optimize patient care by leading the rehabilitation department, ensuring compliance and financial performance while fostering teamwork and excellence in service delivery across multiple sites...
Yesterday
Assoc Dir, Neuro Thought Leader Liaison (Midwest Region)
$190K - $225K *
Transform relationships with key opinion leaders in rare neurological diseases, providing strategic insights and guidance to inform brand strategies and enhance engagement across medical and commercia...
Reposted 2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.