Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$111K - $150K *
Transform product strategy and execution by leveraging data insights, leading cross-functional teams, and prioritizing customer needs to drive product success and business growth in a dynamic environm...
3 weeks ago
Senior Director / Executive Director, Pharmacovigilance
$263K - $325K *
Advance your career by building and leading the pharmacovigilance function from the ground up. In this pivotal role, you'll oversee drug safety operations, collaborate with cross-functional teams, and...
Reposted 1 week ago
21GRAMS- Senior Delivery Manager
$95K - $100K *
Join our dynamic team as a Technical Delivery Manager, overseeing AI-driven project delivery across diverse digital platforms. Ensure timely, high-quality outputs while leveraging innovative technolog...
6 days ago
$216K - $228K *
Transform the research landscape by defining and leading user research practices that connect customer insights to product design across multiple foundational areas, driving high-quality deliverables...
6 days ago
Director of Finance - Ancillary Services
$100K - $115K *
Transform your career by leading financial strategy and operations for innovative service lines. Collaborate with senior leaders to enhance profitability, oversee budgeting, and drive growth initiativ...
2 weeks ago
Sales Manager - Australia/New Zealand Market
$100K - $120K *
Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...
Reposted today
Talent Acquisition Sourcing Specialist
$75K - $115K *
Unlock potential by sourcing top talent through innovative recruiting strategies. Engage with candidates, manage referrals, and support proposal efforts to build a robust talent pipeline for future op...
2 weeks ago
Associate Director, Drug Product, Pulmovant
$130K - $160K *
Lead the technical direction for inhaled dry powder products, ensuring product performance and manufacturability while collaborating with cross-functional teams to navigate development and regulatory...
2 weeks ago
$64K - $162K *
Transform creative visions into reality by leading a talented design team, driving innovative strategies, and ensuring high-quality project execution across various media platforms while collaborating...
4 weeks ago
$80K - $95K *
Join us to lead a dynamic team in optimizing revenue cycle operations for multiple clients. Drive continuous improvement and ensure client satisfaction while managing performance metrics and fostering...
2 days ago
Sr. Director of Machine Learning
$175K - $210K *
Champion the development and strategy of cutting-edge AI services, overseeing a dynamic team of ML engineers and scientists to deliver impactful, reliable, and clinically sound solutions that enhance...
1 month ago
Principal Product Manager, Member Experience
$200K - $230K *
Champion a transformative member software experience, guiding strategy and design across the care journey. Leverage data and user insights to drive impactful solutions in a complex healthcare landscap...
2 weeks ago
$110K - $130K *
Tackle data-driven decisions as a senior product analyst, owning A/B testing design and analysis while collaborating across teams to enhance user experience and drive growth through insightful experim...
Reposted 4 weeks ago
Senior Copywriter, Promotional Medical Writing
$80K - $100K *
Advance impactful medical communications by crafting precise, engaging content. Collaborate with cross-functional teams to ensure accuracy and alignment with client objectives while mentoring junior s...
Yesterday
Senior Data Scientist, People Analytics & Research
$180K - $210K *
Lead the charge in transforming people analytics by applying causal inference and advanced statistical methods to drive strategic decisions on recruitment, retention, and compensation across the organ...
1 week ago
Account Executive - Healthcare (Northeast)
$125K - $150K *
Champion growth by building strategic relationships and driving sales in the Healthcare sector. Leverage AI solutions to enhance customer engagement and achieve revenue targets while collaborating wit...
2 weeks ago
Director, Clinical Development
$165K - $215K *
Empower innovation in ophthalmic device development by leading global clinical strategies for surgical programs, from feasibility to regulatory submissions. Collaborate cross-functionally to drive pro...
Reposted 2 days ago
$157K - $242K *
Join a team that's shaping groundbreaking hardware solutions by defining system architecture, integrating cross-functional requirements, and leading technical direction for complex, production-ready d...
Reposted yesterday
$100K - $120K *
Transform healthcare delivery by providing emergency and primary care at remote worksites. Collaborate with clinical teams to ensure quality assurance and support field staff while maintaining essenti...
6 days ago
$100K - $120K *
Join a team that's dedicated to ensuring compliance and quality in site contracts. Manage negotiations, oversee contract processes, and collaborate with clients and experts to deliver timely and effec...
3 days ago
$130K - $155K *
Lead the charge in transforming complex revenue-cycle challenges into robust, production-ready AI models, ensuring statistical integrity and operational reliability while managing end-to-end data pipe...
6 days ago
Account Specialist, Gainesville-Daytona Beach, FL
$160K - $192K *
Accelerate commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to optimize patient access and support innovative therapies in a dy...
1 week ago
$80K - $95K *
Transform your career by enhancing data security and integrity. Collaborate with cross-functional teams to implement robust security measures, conduct audits, and mitigate risks while staying ahead of...
2 weeks ago
$110K - $130K *
Take ownership of medication therapy management services, conducting comprehensive reviews and consultations. Collaborate with the MTM product team to ensure accurate data entry and enhance patient ca...
Yesterday
Associate Director, Regulatory Project Management
$136K - $220K *
Unlock project management excellence in Global Regulatory Affairs, driving timelines and compliance for drug submissions. Collaborate cross-functionally to ensure accurate documentation and effective...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.