Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$160K *

Drive enterprise-level implementations of phishing-resistant authentication solutions, leading technical deployments and integrations across various identity platforms while ensuring customer success...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$112K - $132K *

Join a team that's shaping the future of autism care by building robust statistical methodologies. You'll analyze real-world clinical data, ensuring rigorous evaluation of outcomes and social validity...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $160K *

Contribute to the evolution of data-driven healthcare products, shaping strategy and execution. Collaborate with cross-functional teams to deliver AI-enabled solutions that enhance clinical outcomes a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Elevate security observability by enhancing Datadog's capabilities across cloud and corporate environments, ensuring actionable detection aligned with real-world threats while collaborating with cross...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive the technical strategy for AI across the organization, ensuring clarity and accountability in AI investments. Collaborate with cross-functional leaders to scale impactful AI initiatives, optimiz...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $192K *

Engage with healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful relat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$106K - $160K *

Join us to define and enhance our financial data offerings, focusing on Private Markets. Collaborate with cross-functional teams to drive product strategy, close content gaps, and ensure seamless inte...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$88K - $113K *

Transform proposal management by leading cross-functional teams to deliver high-quality, compliant responses. Drive efficiency through strategic planning, risk management, and collaboration, ensuring...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$85K - $120K *

Drive excellence in network operations by providing 24/7 support, designing solutions, and ensuring compliance with security best practices. Collaborate with teams to enhance customer connectivity and...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$50K - $114K *

Transform financial operations by driving budgeting, forecasting, and reporting processes. Collaborate with stakeholders to ensure accuracy and alignment in workforce planning, while supporting leader...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Engage with key stakeholders to promote oncology products, build relationships, and drive brand value. Utilize market insights to develop effective strategies, ensuring patient access and compliance w...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$188K - $245K *

Empower innovation by leading a UX design team focused on clinical workflows. Collaborate across functions, drive strategic direction, and enhance AI integration while advancing design quality in heal...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $130K *

Manage the design and implementation of integrated physical security systems, driving innovative solutions in complex environments while fostering collaboration with clients and stakeholders for enhan...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $120K *

Accelerate client success by owning the onboarding and rollout for enterprise clients, ensuring smooth transitions from purchase to sustained usage. Collaborate with cross-functional teams to drive ad...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$222K - $278K *

Drive impactful change by consolidating technologies and digitizing workflows for enterprise customers, while fostering executive relationships and managing complex sales processes that promote safety...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $95K *

Oversee the quality assurance of case reviews, ensuring accuracy and completeness in documentation while collaborating with clinicians to uphold high standards in healthcare determinations and workflo...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Drive the development and execution of U.S. pricing and contracting strategies, optimizing patient access and revenue performance. Collaborate across functions to ensure successful commercialization a...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive incident response excellence by coordinating complex IT incidents, fostering cross-team collaboration, and producing clear, executive-ready communications to mitigate mission impact and enhance...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$63K - $111K *

Join a team that's dedicated to providing top-notch administrative support to program leadership and project personnel, ensuring smooth operations and effective communication across multidisciplinary...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$113K - $142K *

Elevate your career by joining our dynamic team to design, develop, and optimize bioinformatics software tools and systems, ensuring robust functionality and compliance in a fast-paced, innovative env...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$98K - $125K *

Lead the charge in sourcing and procurement for New Product Introductions, ensuring supplier readiness and cost efficiency. Collaborate with cross-functional teams to drive strategic sourcing initiati...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $231K *

Transform healthcare outcomes by leading a team of Clinical Program Consultants to analyze data, optimize clinical programs, and drive strategic initiatives that enhance customer health and reduce cos...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive client success by managing relationships, enhancing satisfaction, and identifying growth opportunities. Collaborate with internal teams to deliver exceptional service and exceed client expectati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$111K - $150K *

Transform product strategy and execution by leveraging data insights, leading cross-functional teams, and prioritizing customer needs to drive product success and business growth in a dynamic environm...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$263K - $325K *

Advance your career by building and leading the pharmacovigilance function from the ground up. In this pivotal role, you'll oversee drug safety operations, collaborate with cross-functional teams, and...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.