Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Casualty Claims Specialist - Specialty Human Services
$101K - $146K *
Lead the charge in managing complex casualty claims, ensuring timely evaluations and settlements while collaborating with stakeholders to uphold coverage standards and compliance. Drive efficiency in...
2 days ago
Medical Review Nurse - CMS/RAC Auditor, Government Audits
$80K - $95K *
Join a team that's dedicated to enhancing healthcare quality through thorough medical claims audits. Leverage your nursing expertise in a dynamic remote environment, collaborating with experienced aud...
2 weeks ago
$110K - $130K *
Lead feasibility strategy and execution for clinical studies, driving operational excellence and data-driven insights to optimize trial planning and enrollment across rare disease programs. Collaborat...
2 days ago
Analyst- Classification, Import/Export
$83K - $114K *
Engage in impactful tariff classification analysis, ensuring compliance and accuracy while collaborating with diverse teams. Drive process optimization and regulatory adherence to enhance business eff...
6 days ago
Professional (Senior) Sales Representative, Pain - Ann Arbor, MI
$100K - $162K *
Join us to develop and implement strategic sales plans, build customer relationships, and achieve sales goals while adhering to ethical practices. Make a positive impact in the pharmaceutical industry...
Reposted 1 week ago
Director of Applied AI Engineering
$207K - $290K *
Elevate your career by leading a dynamic Applied AI team, transforming innovative AI solutions into production-ready systems within a regulated financial environment, while collaborating across depart...
2 weeks ago
$100K - $120K *
Unlock potential by designing and building robust data pipelines for healthcare transactions. Collaborate with partners to ensure seamless integration and reliability of data systems, enhancing operat...
Yesterday
Clinical Documentation Manager
$73K - $115K *
Unlock the potential of clinical documentation integrity by driving ICD-10-CM coding accuracy and enhancing provider education. Collaborate with cross-functional teams to support risk adjustment initi...
1 week ago
$100K - $181K *
Shape the future of nursing education by leading curriculum development, faculty empowerment, and student success initiatives. Drive compliance and foster collaboration to enhance academic operations...
2 weeks ago
Associate Director, CMC Operations
$155K - $190K *
Manage the planning and execution of CMC operations across multiple development programs, ensuring alignment with regulatory milestones and efficient collaboration with cross-functional teams and CDMO...
1 week ago
$110K - $130K *
Elevate client success by managing complex projects, ensuring timely delivery, and maintaining budget integrity. Collaborate with diverse teams to drive engagement and optimize project outcomes from i...
3 weeks ago
$201K *
Optimize your leadership skills in a dynamic role, guiding a skilled team of product managers and designers. Drive impactful product strategies that shape the future of justice and promote sustainable...
Reposted 3 weeks ago
Account Specialist (Burlington, MA)
$160K - $192K *
Elevate commercial performance by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring complian...
1 week ago
Account Specialist, Palos Heights, IL
$160K - $192K *
Accelerate progress at the forefront of healthcare by driving commercial performance, building relationships with providers, and ensuring patient access to innovative therapies across a defined territ...
1 week ago
$90K - $110K *
Advance your career by delivering critical cost estimates for federal programs. Collaborate with a dynamic team to enhance national security through effective budgeting and analysis of advanced commun...
1 week ago
$164K - $305K *
Lead the charge in developing strategic relationships with C-suite executives to drive growth, retention, and value realization across complex health systems, ensuring integrated solutions and measura...
1 week ago
Consultant Relations Senior Manager
$170K - $200K *
Elevate our Enterprise business by building impactful relationships with brokers and consultants. Drive engagement strategies, generate new business opportunities, and enhance BetterHelp's presence in...
2 weeks ago
Senior Oncology Account Manager, Raleigh
$150K - $230K *
Join a dynamic team as you manage oncology product promotions, build relationships with key stakeholders, and drive brand value through strategic engagement and innovative solutions in a competitive b...
1 week ago
Senior Product and Design Strategist
$192K - $240K *
Unlock your potential as a Product + Design Strategist, leading ambiguous projects from concept to execution. Collaborate with cross-functional teams to create innovative, user-centered experiences an...
Reposted 4 weeks ago
$270K - $290K *
Join a team that's shaping innovative brand strategies for rare epilepsy programs. Lead marketing initiatives, drive launch readiness, and build a high-performing team to deliver impactful solutions f...
1 week ago
$150K - $195K *
Elevate client relationships by managing key accounts, driving satisfaction and growth. Collaborate with internal teams to deliver tailored solutions, ensuring long-term success and measurable ROI for...
3 weeks ago
$90K - $110K *
Empower the Foot and Ankle team by driving growth and building key relationships. Engage with surgeons in the operating room and support sales initiatives to enhance product adoption and customer sati...
3 weeks ago
$190K - $300K *
Build strategic relationships with scientific leaders to drive innovation in Pulmonary Hypertension. Engage in scientific exchange, support research initiatives, and enhance understanding of therapeut...
Reposted 1 week ago
$110K - $130K *
Explore your career by building strategic partnerships in the life sciences sector. Drive account growth, develop client relationships, and connect with key stakeholders to enhance business opportunit...
Reposted 2 weeks ago
Field Clinical Manager (Remote)
$175K - $230K *
Empower healthcare innovation by leading a team of Field Clinical Specialists. Drive the successful launch of the Globe Pulsed Field System through training, support, and relationship-building with he...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.