Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$90K - $105K *

Optimize healthcare support by serving as the primary contact for clinical application issues. Collaborate with clinicians and IT teams to troubleshoot, educate, and resolve technical challenges, ensu...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Staffing

$120K - $140K *

Drive compliance excellence as a Senior Compliance Program Manager, overseeing complex initiatives across enterprise and federal environments. Collaborate with cross-functional teams to ensure audit r...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $140K *

Transform your career by providing clinical support and training in surgical procedures. Collaborate with surgical teams to ensure optimal patient outcomes while managing inventory and compliance in a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $160K *

Pioneer data-driven insights by collaborating with cross-functional teams to enhance business strategies. Leverage advanced analytics and visualization skills to drive operational improvements and sup...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$172K - $202K *

Lead the charge in delivering expert guidance on identity and access management technologies, focusing on architecting solutions and producing actionable research to enhance client performance and sec...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Business Services

$166K - $195K *

Shape the future of talent acquisition by leading full-lifecycle recruiting for senior roles. Collaborate with leaders to enhance hiring strategies, build strong candidate pipelines, and drive process...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $120K *

Champion the development of high-quality program materials and deliverables, enhancing effectiveness in complex specialty markets. Collaborate with teams to ensure project success through strong manag...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $125K *

Join a team that's dedicated to delivering accurate sales reporting and data maintenance. This role supports sales leaders and partners by managing reporting queues, ensuring data integrity, and enhan...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $150K *

Join a team that's dedicated to advancing radiopharmaceuticals! Lead CMC strategies and cross-functional collaboration to ensure successful readiness for commercial viability, market expansion, and co...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$67K - $100K *

Reimagine patient care by operating MRI equipment to produce diagnostic images. Collaborate with healthcare professionals to ensure efficient procedures and maintain high standards in a dynamic enviro...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $125K *

Accelerate progress at the intersection of finance and strategy, driving cost accounting excellence and profitability analysis. Collaborate with cross-functional teams to enhance financial reporting a...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$171K - $231K *

Drive innovative patient recruitment strategies to enhance clinical trial enrollment and retention. Collaborate with cross-functional teams to implement data-driven approaches, optimize patient engage...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$73K - $100K *

Elevate workforce planning by transforming data into impactful insights. Partner with leaders to build strategic forecasting tools and measure performance metrics, contributing to operational efficien...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Drive the promotion of oncology products by building relationships with key stakeholders, exceeding performance goals, and ensuring patient access to therapies while managing territory resources effec...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $150K *

Unlock potential by leading claims adjudication logic to enhance accuracy and efficiency. Drive strategic improvements, collaborate across teams, and ensure compliance while optimizing operations in a...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $200K *

Join us to investigate and resolve platform issues, ensuring quality across campaigns. Collaborate with cross-functional teams to enhance processes, automate checks, and maintain high standards in a f...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$123K - $157K *

Advance your career by leading strategic sourcing for metals, driving cost savings and supplier performance. Engage with cross-functional teams to influence decisions and ensure supply continuity whil...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Engage with mid-sized General Contractors to drive revenue growth. Manage the full sales cycle, from outreach to contract signing, while delivering exceptional customer experiences and exceeding sales...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$155K - $175K *

Serve as a key scientific partner in the field, driving prelaunch and launch strategies through trusted relationships, high-quality exchanges, and actionable insights to enhance product adoption and c...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $147K *

Drive clinical project performance by leading teams in the execution of research trials. Collaborate with stakeholders to ensure operational excellence, manage budgets, and mitigate risks while foster...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $189K *

Elevate organizational efficiency by leading Workday Absence and Time Tracking solutions. Collaborate cross-functionally to optimize processes, ensuring compliance and enhancing user experience as the...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Engage with senior stakeholders to enhance R&D efficiency in life sciences. Drive proposals, develop strategies, and ensure quality oversight while building networks to support business development an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$117K - $146K *

Lead the charge in developing innovative algorithms and pipelines for early cancer detection, collaborating with cross-functional teams to analyze complex genomic datasets and enhance clinical diagnos...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$250K - $280K *

Shape the future of our enterprise sales segment by driving growth and account success. Take ownership of new logo acquisitions, deepen existing client relationships, and establish best practices for...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$101K - $146K *

Lead the charge in managing complex casualty claims, ensuring timely evaluations and settlements while collaborating with stakeholders to uphold coverage standards and compliance. Drive efficiency in...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.