Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$200K - $230K *

Join a team that's shaping the future of migraine treatment by leading U.S. marketing strategies. Drive brand awareness and engagement through innovative campaigns, collaborating across functions to e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $206K *

Advance health outcomes by providing in-home evaluations, fostering trust and personalized care. Engage with patients to bridge gaps in health services, ensuring comprehensive support tailored to indi...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower your career by leading sales strategies across the US. Collaborate with a dynamic team to drive growth, develop client relationships, and deliver impactful presentations while navigating indus...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Join us to lead regional sales efforts, driving product launch success and team performance. You'll build strong customer relationships, execute strategic plans, and foster a high-performing culture i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Unlock potential by providing clinical and administrative leadership to enhance patient care standards. Collaborate with medical staff and departments to ensure compliance and drive strategic initiati...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$71K - $118K *

Engage in advanced nuclear imaging procedures, ensuring patient safety and quality care. Collaborate with a skilled team using state-of-the-art technology to deliver diagnostic and therapeutic service...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $190K *

Lead formulation development from discovery to clinical stages, translating compounds into scalable processes. Collaborate with cross-functional teams to drive strategy, solve challenges, and ensure q...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $155K *

Champion product innovation by managing software initiatives that enhance internal communication and streamline operations. Collaborate with cross-functional teams to deliver impactful solutions and d...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Staffing

$129K - $190K *

Empower cross-functional teams by providing expert legal counsel on product development, privacy, and compliance in the ad-tech space. Collaborate closely with engineering, marketing, and product team...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Collaborate with healthcare professionals to enhance patient access and exceed performanc...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $130K *

Lead the charge in enhancing member care as you coach and develop clinical teams, oversee daily operations, and ensure compliance with regulatory standards while driving quality improvements and opera...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$155K - $175K *

Drive impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and ensuring successful product adoption in a dynamic prelaun...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$220K - $255K *

Shape the future of healthcare by leading strategic payor relationships and driving reimbursement strategies. Collaborate cross-functionally to enhance patient access and optimize coverage for innovat...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$157K - $256K *

Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$140K - $180K *

Join a team that's dedicated to developing scalable software solutions, designing responsive UIs, and optimizing backend services. Collaborate across functions to drive innovation and champion best pr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $140K *

Empower patient care by providing clinical support and training to surgical teams. Collaborate closely with healthcare professionals to ensure optimal outcomes and maintain equipment standards while m...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $190K *

Lead the charge in driving sales growth within the Pulmonary therapeutic area by building strong relationships with healthcare professionals and implementing strategic initiatives to enhance product u...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$79K - $127K *

Optimize member health outcomes by managing complex care plans, coordinating services, and advocating for quality, cost-effective healthcare. Collaborate with healthcare teams to assess needs and moni...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team as a strategic partner to senior living operators, driving adoption and ROI. Leverage your clinical expertise and commercial acumen to enhance client relationships and ensure succe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $120K *

Join a dynamic team as a Medical Claims Auditor, ensuring compliance and integrity in healthcare payments. Collaborate with cross-functional teams to identify fraud, waste, and abuse while leveraging...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Elevate patient care by driving oncology product success through strategic relationships and innovative solutions. Lead efforts in territory management, market analysis, and collaborative engagement t...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Partner with us to enhance client relationships and drive growth. In this role, you'll manage a diverse portfolio, ensuring customer retention and identifying new opportunities while collaborating wit...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$80K - $110K *

Transform clinical data into engaging scientific content with growth opportunities. Collaborate, communicate, and adhere to guidelines in a dynamic environment, supporting varied projects across forma...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $182K *

Analyze healthcare costs and quality outcomes to drive value-based care strategies, collaborating with clinical and financial teams. Lead data-driven insights and financial modeling to enhance operati...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.