Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$191K - $305K *
Champion innovative healthcare solutions by leveraging clinical expertise to enhance value-based strategies, drive operational excellence, and foster strategic partnerships for improved member care an...
3 weeks ago
$180K - $220K *
Empower a dynamic team of software engineers to innovate and deliver impactful tech solutions, collaborating with cross-functional partners to enhance pediatric healthcare for children with special ne...
3 weeks ago
Director - AI Digital Product Management - Commercial Value & Access
$199K - $269K *
Grow your career with a leadership role in AI Digital Product Management, driving strategy and innovation across a portfolio of AI products. Collaborate with cross-functional teams to deliver scalable...
3 weeks ago
Associate Director, Virtual Health
$115K - $125K *
Elevate virtual health services by leading strategic initiatives, enhancing patient experiences, and driving operational excellence. Collaborate across teams to implement innovative care models and en...
2 days ago
Senior Oncology Account Manager, Boston South
$150K - $230K *
Champion your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...
1 week ago
Senior Analyst, Asset Based Lending Field Exam
$95K - $115K *
Lead the future of asset-based field examinations by delivering insightful analyses, evaluating financial controls, and ensuring compliance. Collaborate with clients to assess collateral values and mi...
6 days ago
Registered Nurse (RN) | Behavioral Health Senior Unit
$67K - $100K *
Support patient care by delivering nursing services in a challenging behavioral health environment. Collaborate with a multidisciplinary team to provide critical medical and mental health care to elde...
Reposted yesterday
Senior Risk Adjustment Coding Analyst
$86K - $118K *
Join a team that's dedicated to enhancing consumer experiences through innovative solutions. Leverage your technical expertise in a collaborative environment focused on continuous improvement and impa...
Reposted today
Director, Global Drug Safety & Pharmacovigilance Operations
$150K - $180K *
Advance global drug safety initiatives by leading pharmacovigilance activities, ensuring compliance with regulations, and collaborating with cross-functional teams to enhance product safety and operat...
2 days ago
Manager, Clinical Data Management Study Lead
$114K - $187K *
Optimize clinical data management processes by leading teams and ensuring compliance with standards. Collaborate with stakeholders to enhance data quality and streamline operations across multiple com...
2 days ago
HCP Personal Marketing Lead - Epilepsy
$190K - $214K *
Lead HCP personal promotion strategy, developing and optimizing initiatives that engage healthcare professionals. Collaborate cross-functionally to ensure compliance and effectiveness in promotional t...
3 days ago
Director, Access Strategy & Marketing
$201K - $251K *
Elevate access strategies and marketing initiatives for oncology products, focusing on non-clinical value propositions. Collaborate cross-functionally to ensure successful product launches and effecti...
3 days ago
$122K *
Join a team that's driving growth in the home care sector by securing corporate partnerships and expanding agency networks. This role requires strategic engagement with executive stakeholders to enhan...
1 week ago
Senior Oncology Account Manager, Orange County
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with healthcare stakeholders while driving performance goals and ensuring patient access to innovative therapies in a dynamic...
1 week ago
$95K - $115K *
Lead the implementation and management of client Speaker Bureau operations, ensuring successful educational programs in the pharmaceutical sector. Collaborate with cross-functional teams to exceed cli...
Yesterday
Program Executive, Drug Development and Commercial
$285K - $325K *
Drive transformational patient impact by leading cross-functional teams and executing strategic drug development programs in an agile environment. Foster collaboration and accountability to deliver in...
Reposted 2 weeks ago
$110K - $130K *
Unlock potential by owning the end-to-end product surface, driving discovery, design, and migration while collaborating closely with users to solve real market problems in a dynamic healthcare environ...
3 weeks ago
Quality Control, Validation Lead
$110K - $130K *
Join a team that's shaping the future of Quality Control laboratories by providing technical oversight for startup, validation, and compliance across multiple manufacturing sites, ensuring operational...
2 weeks ago
Medical Science Liaison (Southwest)
$120K - $145K *
Shape the future of healthcare by providing expert medical insights and support for our product portfolio. Collaborate with healthcare professionals and key opinion leaders to enhance understanding an...
3 weeks ago
$70K - $106K *
Champion patient care by coordinating and delivering occupational therapy services to improve health outcomes, engaging with interdisciplinary teams to develop tailored treatment programs for diverse...
Reposted 2 weeks ago
Advisor, Bio Sample Operations - DMPK
$153K - $268K *
Empower your career by leading bio sample operations across clinical studies. Oversee end-to-end processes, ensuring compliance and quality while collaborating with cross-functional teams and external...
6 days ago
Senior Oncology Account Manager, Jackson
$150K - $230K *
Unlock your potential by driving oncology product success through strategic relationships and innovative solutions. Collaborate with key stakeholders to enhance patient access and exceed performance g...
1 week ago
Executive Recruiter - College President Search
$100K - $120K *
Unlock your potential by guiding higher education leadership searches. Collaborate with institutional leaders to define candidate profiles, engage top talent, and manage the selection process, ensurin...
1 week ago
$83K - $140K *
Lead the charge in financial modeling and forecasting, driving strategic insights and collaborative planning processes across Corporate Finance & Strategy to optimize performance and align financial g...
Reposted 4 weeks ago
$108K - $162K *
Champion customer support by managing maintenance services and operations. Lead a team to ensure timely resolutions and enhance product performance while utilizing technical expertise and strategic pl...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.