Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$175K - $400K *
Elevate your career by managing the lifecycle of vendor agreements and contracts. Collaborate across departments to ensure compliance and streamline workflows, safeguarding business interests while mi...
3 weeks ago
Senior Medical Science Liaisons (MSL) - Cardiovascular, Florida
$190K - $225K *
Drive scientific engagement as a Senior Medical Science Liaison, fostering relationships with Key Opinion Leaders and healthcare professionals. Leverage your expertise in cardiovascular disease to sup...
2 weeks ago
Clinical Research Associate II - FSP
$91K - $137K *
Shape the future of clinical research by managing site operations, ensuring patient safety, and maintaining data integrity. Collaborate with study teams to oversee monitoring activities and drive succ...
3 days ago
Clinical Research Associate II - FSP
$91K - $137K *
Empower your career by managing clinical research sites, ensuring patient safety, and maintaining data integrity. Collaborate with teams to oversee study implementation and monitoring, while enhancing...
3 days ago
Director of Nursing - RN - Long Term Care
$85K - $100K *
Lead the nursing program in a long-term care facility, ensuring high resident care standards and compliance with regulations. Collaborate with staff and administration to enhance the quality and effic...
Reposted 2 weeks ago
Senior Financial Analyst (Consolidation)
$100K - $120K *
Lead the consolidation of financial models and metrics, partnering with cross-functional teams to deliver actionable insights and support strategic decision-making across the organization...
2 days ago
Senior Legal Analyst & Litigation Project Manager
$92K - $124K *
Partner with us to enhance legal operations and implement eDiscovery processes. You'll lead customer data privacy initiatives, improving cross-functional collaboration and response strategies for comp...
Reposted 4 weeks ago
Computer Systems Validation Engineer
$150K - $178K *
Pioneer a comprehensive Computer System Validation strategy across GxP systems. Collaborate with Quality and IT to drive compliance and data integrity while enhancing efficiency in validation processe...
Reposted 2 weeks ago
Lab Point of Care Sales Specialist
$100K - $115K *
Unlock potential by providing vital sales support and presentations, driving customer integration and product utilization, while conducting market research to enhance offerings. Collaborate closely wi...
Reposted 1 week ago
Application Security Engineer, Generative AI
$184K - $250K *
Accelerate progress at the forefront of application security, driving secure software development and fostering a culture of security across engineering teams while managing risks and enhancing securi...
Yesterday
Manager, Market Access & Reimbursement
$145K - $218K *
Architect innovative market access strategies to enhance U.S. reimbursement for cutting-edge healthcare solutions. Collaborate across functions to drive payer engagement, coding, and coverage initiati...
2 weeks ago
Senior Strategic Account Executive, Private Equity Partnerships
$150K - $180K *
Empower growth by leading private equity partnerships, driving telehealth solutions across portfolios. Build relationships, negotiate agreements, and create a repeatable deployment model to enhance he...
2 weeks ago
$94K - $136K *
Transform financial insights into strategic decisions by providing advanced analytical support across Finance, Operations, and Strategic Planning. Collaborate with leadership to drive impactful projec...
1 week ago
Unified Communications Analyst
$80K - $95K *
Champion seamless communication by managing VoIP and telephony systems, ensuring optimal performance and user satisfaction. Collaborate across departments to analyze data, enhance workflows, and uphol...
2 weeks ago
Clinical Research Associate II
$80K - $95K *
Lead the execution of clinical trials by monitoring site activities, ensuring compliance with regulations, and collaborating with teams to achieve study objectives. Play a key role in training site st...
1 week ago
21GRAMS- Director, Product Design
$140K - $155K *
Empower teams to elevate product design through strategic vision, fostering collaboration across disciplines to create impactful digital experiences that meet user needs and business goals while ensur...
6 days ago
Vice President, Software Engineering
$278K - $361K *
Accelerate progress at the forefront of software engineering leadership, driving innovation and operational excellence in regulated medical technology. Lead teams to deliver scalable, high-quality sof...
Reposted 6 days ago
$78K - $98K *
Transform customer experiences by leading complex software implementations, ensuring seamless onboarding, testing, and launch activities. Leverage advanced product knowledge and project coordination s...
4 weeks ago
$140K - $175K *
Drive operational excellence by leading strategic initiatives and managing a team to enhance Care Operations. Transform high-level strategies into scalable systems that improve care delivery and patie...
2 weeks ago
Senior Consultant - Strategic Sourcing & Procurement Transformation
$110K - $130K *
Join a team that's transforming procurement operations through innovative strategies and data-driven solutions. Leverage your consulting expertise to enhance client outcomes and drive impactful change...
1 week ago
Associate Dean Academic Affairs - BSN Online Program Mentor
$70K - $142K *
Lead the charge in enhancing academic operations and faculty performance, ensuring compliance with accreditation standards while fostering student success through strategic curriculum development and...
3 weeks ago
Regional Sales Director - Long Island
$180K - $215K *
Inspire growth by leading regional launch strategies and building high-performing sales teams. Drive market success through strong customer relationships and cross-functional collaboration in a fast-p...
1 week ago
Regional Sales Director - Birmingham
$180K - $215K *
Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Collaborate cross-functionally to achieve strategic goals in a fast-pace...
1 week ago
Senior Manager, REMS Operations
$141K - $212K *
Deliver strategic oversight and operational management for FDA-mandated REMS programs, ensuring compliance, governance, and collaboration across teams and vendors to enhance program effectiveness and...
4 weeks ago
$115K - $158K *
Join us to shape the future of member experiences in healthcare by leading innovative design projects, collaborating with cross-functional teams, and enhancing service delivery through user-centered d...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.