Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Consultant, Healthcare Finance (Healthcare & Medicaid Finance and Analysis)
$95K - $130K *
Unlock potential by driving healthcare finance consulting excellence. Collaborate with project teams to enhance service delivery through financial modeling, data analytics, and quality improvement ini...
1 week ago
Recruiting Coordinator - Contractor
$83K *
Transform the candidate experience by coordinating interviews and managing communications. Collaborate with recruiters and hiring managers to streamline processes, ensuring efficiency and excellence i...
2 weeks ago
Value & Access Insights Sr. Manager, Medical Benefit Products
$163K - $220K *
Shape the future of healthcare by leading analytics for managed care, driving payer strategies, and delivering insights to enhance access to medical benefit products. Collaborate with cross-functional...
3 weeks ago
Global Patient Safety Business Excellence, Senior Manager
$140K - $190K *
Lead the charge in driving business excellence initiatives across Global Patient Safety. Collaborate with cross-functional teams to enhance project management, governance, and operational effectivenes...
Reposted 2 weeks ago
Senior Oncology Account Manager, San Francisco
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...
1 week ago
Program Manager, Medical Communications
$70K - $105K *
Collaborate with cross-functional teams to drive project execution and operational excellence in medical communications. Leverage your project management skills to ensure timely delivery and high-qual...
1 week ago
Account Specialist (Johnson City, TN)
$160K - $192K *
Engage healthcare providers and drive commercial performance in a defined territory. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative therapi...
1 week ago
eDiscovery Analyst, Enterprise Accounts
$100K - $120K *
Champion the management and execution of complex e-discovery projects, collaborating with legal teams to ensure successful outcomes. Oversee multiple projects while mentoring a team, maintaining quali...
2 weeks ago
Senior Manager, Clinical Operations
$136K - $171K *
Pioneer clinical trial excellence by leading operational planning and execution. Collaborate cross-functionally to ensure compliance, quality, and timely delivery of clinical studies while mentoring j...
1 week ago
Senior Account Manager - Central
$85K - $95K *
Join a dynamic team to deliver exceptional client service, manage accounts, and enhance relationships with AmLaw firms. Drive success through proactive communication, issue resolution, and a client-fi...
2 weeks ago
$140K - $153K *
Join a team that's dedicated to enhancing healthcare quality through innovative testing strategies. Collaborate with cross-functional teams to ensure robust, user-centered products while mentoring jun...
4 weeks ago
Pharmacist | Cancer Care Institute
$100K - $120K *
Empower patient health by using your clinical expertise to oversee medication management and collaborate with healthcare professionals, ensuring optimal therapeutic outcomes across care settings for d...
Reposted today
Regional Sales Director - Memphis
$180K - $215K *
Lead the charge in regional sales execution, driving product launch success and team performance through strategic planning, customer engagement, and cross-functional collaboration in a dynamic enviro...
1 week ago
$63K - $96K *
Accelerate progress at the forefront of clinical technology, supporting multi-user systems and enhancing workflows. Collaborate with teams to optimize applications, ensuring effective use and continuo...
Yesterday
Director of Tier 3 and Support Engineering
$125K - $150K *
Lead the charge in enhancing customer support by managing Tier 3 Support and Support Engineering teams. Drive technical resolutions, streamline escalations, and foster team development within a dynami...
2 weeks ago
Registered Nurse (RN) | Med Surg
$67K - $100K *
Shape the future of patient care by delivering comprehensive nursing services, developing care plans, and providing emotional support to patients and families while collaborating with healthcare teams...
1 week ago
$96K - $108K *
Transform patient care by joining our dynamic hospice team as a Travel RN. Provide compassionate support across multiple locations, ensuring quality and continuity of care while collaborating with loc...
2 weeks ago
RN Clinical Documentation Informaticist - Remote (see full posting for eligible states)
$80K - $95K *
Advance clinical documentation accuracy by collaborating with healthcare teams to ensure comprehensive patient records, reflecting severity of illness and risk of mortality, while maintaining complian...
1 week ago
Associate, Corporate Development
$115K - $140K *
Drive impactful growth by mapping industrial markets, evaluating acquisition targets, and building investment models. Collaborate on live transactions to shape strategic decisions that enhance manufac...
2 weeks ago
$120K - $140K *
Innovate cloud solutions by designing and automating infrastructure in Cloud.gov and Azure. Collaborate with teams to enhance performance and security, driving impactful results for clients while shap...
Reposted 2 days ago
Healthcare Payment Solutions Consultant - Enterprise Market
$126K - $154K *
Transform healthcare payment solutions by driving business growth and optimizing client relationships. Leverage your expertise to develop tailored proposals and secure long-term partnerships with larg...
1 week ago
$85K - $100K *
Drive clinical excellence by partnering with agency leaders to assess, develop, and deliver tailored education programs for nursing staff, ensuring compliance and enhancing patient care across a netwo...
Yesterday
Staff Biostatistician (Clinical Validation)
$164K - $205K *
Lead the design and analysis of clinical validation studies, ensuring regulatory compliance and driving innovative research in molecular diagnostics. Collaborate with cross-functional teams to enhance...
2 weeks ago
Senior Manager, Growth Marketing
$110K - $130K *
Accelerate progress at an innovative healthcare firm by leading account-based marketing initiatives. Collaborate closely with Sales to create impactful marketing plays that engage targeted health syst...
1 month ago
Patient Marketing Manager - Epilepsy
$176K - $196K *
Transform patient engagement by leading innovative marketing strategies for relutrigine, enhancing the treatment journey for epilepsy patients and caregivers. Drive impactful initiatives through cross...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.