Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$101K - $146K *
Unlock potential by leading payer contract negotiations to enhance relationships, optimize revenue, and ensure compliance with regulations, all while aligning with strategic priorities of the health s...
3 weeks ago
Cardiovascular Account Specialist - U.S. Sales, Pasadena, CA
$162K - $195K *
Deliver impactful sales strategies and cultivate strategic partnerships to launch a groundbreaking cardiac treatment in your territory, effectively addressing unmet patient needs while collaborating w...
1 month ago
Senior Regulatory Submissions Lead
$145K *
Drive innovation and transform lives by leading regulatory strategies and submissions for clinical trials globally. Act as a key liaison for project teams to ensure compliance, operational excellence...
Reposted 1 week ago
$80K - $100K *
Unlock insights by analyzing customer and operational data to enhance business outcomes. Collaborate with cross-functional teams to develop dashboards and reports that drive strategic decisions and im...
3 weeks ago
Senior Regulatory Affairs Specialist (Remote - United States)
$124K - $170K *
Champion regulatory strategies to accelerate product approvals and compliance. Lead a dynamic team in supporting innovative medical devices, ensuring alignment with global regulations while fostering...
1 week ago
Associate Director, Regulatory Science
$177K - $221K *
Champion regulatory excellence by leading cross-functional teams, ensuring compliance, and driving successful oncology drug development through strategic planning and expert guidance...
1 week ago
$120K - $145K *
Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...
Today
Associate Director, Social Media
$90K - $115K *
Elevate your career by leading innovative social media programs that connect healthcare clients with their audiences. Drive strategic content development and manage cross-functional teams to ensure im...
Reposted 2 weeks ago
$76K - $96K *
Discover a rewarding career as a Registered Nurse, where you'll deliver compassionate, quality care, collaborate with healthcare teams, and impact patients' lives through expert clinical practice and...
1 month ago
$95K - $115K *
Transform healthcare delivery by leveraging your Epic Cadence expertise to design, build, and optimize scheduling workflows. Collaborate with teams to ensure successful project outcomes and enhance pa...
Yesterday
Endpoint Engineer I (JAMF & Mac Experience required)
$80K - $100K *
Take ownership of complex desktop and mobile device support, ensuring high customer satisfaction. Administer enterprise management platforms and collaborate with teams to deliver effective technology...
1 week ago
Endpoint Engineer I (JAMF & Mac Experience required)
$80K - $100K *
Transform endpoint management by leading complex support initiatives, ensuring seamless service delivery across diverse environments. Collaborate with teams to enhance user experience and optimize tec...
1 week ago
Hospital Coding Quality Integrity Analyst - Inpatient
$73K - $110K *
Elevate your career by ensuring coding accuracy and compliance in a dynamic healthcare environment. Collaborate with teams to enhance documentation quality and drive improvements in coding practices w...
3 weeks ago
$90K *
Empower public safety by driving new business in private EMS. As an Account Executive, you'll build relationships, manage sales cycles, and collaborate with teams to enhance community engagement throu...
3 weeks ago
$100K - $120K *
Drive evidence-based healthcare improvements by leading evaluations and strategic analyses. Collaborate with multidisciplinary teams to enhance Military Health System outcomes through expert consultat...
3 weeks ago
$100K - $120K *
Transform payment strategies by analyzing interchange and routing data to optimize costs and enhance performance. Leverage advanced analytics and automation to deliver actionable insights for stakehol...
Today
$165K - $215K *
Shape the future of value-based payments by leading product strategy, overseeing team development, and driving market innovations within a collaborative, cross-functional environment...
4 weeks ago
Senior Medical Physicist (Truckee, CA)
$190K - $262K *
Join us to ensure high-quality radiation therapy through expert oversight, compliance, and innovative practices. Collaborate with a dedicated team to enhance patient safety and deliver exceptional car...
1 week ago
Associate Director, Global Value & Access, Hematology
$153K - $203K *
Drive global access and pricing strategies for hematology assets, ensuring timely reimbursement and optimal patient access. Collaborate with cross-functional teams to develop evidence-based toolkits a...
3 weeks ago
Technical Support Engineer (New England)
$72K - $112K *
Serve as a vital technical support resource in healthcare technology, ensuring system stability and customer satisfaction while managing service requests and collaborating with teams for quick resolut...
Reposted 3 weeks ago
Registered Nurse (RN) | Long Term Care
$67K - $100K *
Join a dedicated team providing compassionate nursing care and support to residents, families, and healthcare colleagues. Develop care plans, evaluate outcomes, and ensure a safe environment while pro...
Reposted 1 week ago
$252K - $315K *
Champion psychiatric practice excellence by developing standards and frameworks, enhancing clinician support, and driving quality improvement initiatives to elevate patient outcomes and operational ef...
3 weeks ago
Manager, Revenue Cycle Operations
$100K - $130K *
Join a dynamic team to lead and enhance billing and coding operations, ensuring quality and compliance across multiple markets. Drive performance, coach leaders, and collaborate cross-functionally to...
3 weeks ago
Hemostasis Sales Specialist - Northern California Region
$99K - $136K *
Elevate your career by driving strategic growth in Hemostasis solutions. As a key player, you'll lead complex sales cycles, cultivate executive relationships, and deliver measurable value across healt...
2 weeks ago
$90K - $103K *
Develop and optimize health and welfare plans, ensuring compliance and efficient administration. Collaborate with TPAs, oversee claims performance, and enhance employee engagement through effective co...
1 month ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.