Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$95K - $110K *
Discover user needs and drive product decisions as a UX Researcher, collaborating with cross-functional teams to conduct research, usability studies, and synthesize insights that enhance user experien...
2 days ago
Sr Regional Oncology Business Manager, Nashville
$130K - $160K *
Unlock potential by driving sales and education in oncology medical devices. Collaborate with healthcare professionals to enhance treatment options for liver and pancreatic cancer while achieving regi...
1 week ago
Head of Clinical Quality and Regulatory
$208K - $220K *
Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...
1 week ago
Registered Nurse (RN) Case Manager | Avera Health Plans Medical Management
$64K - $96K *
Lead the charge in providing comprehensive case management for chronic conditions, collaborating with healthcare teams to optimize care plans and improve patient outcomes in a cost-effective manner, i...
Reposted 1 week ago
$110K *
Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...
Reposted 3 days ago
Senior Director, European Regulatory Strategy Lead
$160K - $259K *
Champion regulatory excellence by leading European strategies for innovative therapies. Drive successful submissions and interactions with health authorities, ensuring compliance and alignment across...
2 weeks ago
Senior Vice President, Payer Sales
$225K - $250K *
Elevate your career by leading payer sales strategy and team development, driving new business opportunities in healthcare technology. Collaborate with executives to enhance performance and deliver im...
2 weeks ago
$80K - $95K *
Help us manage diverse projects that drive strategic growth and collaboration across teams. As a key member of the EPMO, you'll ensure project success through effective stakeholder management and cont...
1 week ago
Global Quality Assurance Auditor, Pharmacovigilance
$102K - $153K *
Champion compliance and quality assurance in the Pharmaceutical Diagnostics sector. Drive audits, analyze trends, and support regulatory inspections to enhance operational excellence and ensure adhere...
Yesterday
Commissioning Associate Director
$156K - $200K *
Champion the commissioning of hyperscale data centers by leading project teams, managing schedules, and ensuring compliance with technical standards. Collaborate with stakeholders to deliver successfu...
3 days ago
$80K - $95K *
Transform inpatient coding operations by leading a dedicated team to ensure accurate coding, compliance, and timely billing. Collaborate with clinical and administrative staff to enhance financial per...
Yesterday
Director, Medical Science Liaison (East)
$148K - $222K *
Drive clinical adoption and enhance partnerships by leading a high-performing Medical Science Liaison team. Collaborate with sales and medical teams to educate stakeholders, influence decision-making...
1 week ago
Nursing Supervisor - Registered Nurse - RN - Pulmonary Clinic
$76K - $106K *
Elevate patient care by supervising nursing operations and enhancing clinical processes. Collaborate with a dedicated team to ensure quality outcomes and maintain effective relationships within a dyna...
Reposted today
$72K - $120K *
Lead a multi-disciplinary team in developing machine learning algorithms to enhance clinical decision support, leveraging healthcare datasets for innovation and making vital discoveries that drive pro...
Reposted 3 weeks ago
Senior Manager, PVRM Safety Scientist
$157K - $196K *
Drive safety evaluation and risk management for assigned programs, collaborating with cross-functional teams to ensure compliance and effective governance in pharmacovigilance activities, while suppor...
Today
Senior Manager, Global Sourcing – Plastics
$123K - $157K *
Lead the charge in global sourcing strategies for plastics, driving supplier relationships and cost optimization while ensuring supply continuity and supporting new product introductions across manufa...
2 days ago
$94K - $107K *
Transform data governance operations by driving process adoption, supporting data stewards, and enhancing governance tools. Collaborate with teams to ensure compliance, improve workflows, and leverage...
3 weeks ago
In-Home Traveler Nurse Practitioner or Physician Assistant Full Time - DE
$87K - $187K *
Explore a rewarding role providing in-home health evaluations, fostering relationships to enhance patient care. Travel extensively to deliver personalized health services, ensuring comprehensive suppo...
3 weeks ago
Senior Applications Administrator
$67K - $108K *
Optimize collaboration and data governance by managing Microsoft 365 services, focusing on SharePoint Online and data protection. Partner with teams to enhance compliance, security, and operational ef...
3 weeks ago
Senior Account Manager, Life Sciences (Los Angeles)
$120K - $150K *
Drive customer satisfaction and sales in life sciences by leveraging your expertise to build relationships and execute strategic initiatives with key accounts in academia and industry...
2 weeks ago
$88K - $105K *
Join a team that's dedicated to delivering exceptional client service and operational excellence. As a Program Manager, you'll oversee program execution, account management, and financial oversight wh...
2 weeks ago
Staff Nurse Practitioner, Primary Care
$127K *
Contribute to transforming virtual primary care by delivering exceptional patient assessments, treatment plans, and ongoing support. Collaborate with healthcare teams while leveraging technology to en...
Reposted 3 weeks ago
Senior Manager, In-Vitro Diagnostics/Precision Medicine Quality
$132K - $178K *
Champion quality in In-Vitro Diagnostics and Companion Diagnostics. Lead proactive strategies, ensuring compliance in clinical trials while collaborating with partners to enhance precision medicine in...
3 weeks ago
$130K - $150K *
Join a team that's shaping high-impact strategies and narratives for enterprise growth. Collaborate with senior leaders to craft compelling pitches and support organic initiatives, driving success acr...
Reposted 2 weeks ago
$130K - $160K *
Drive growth as an integral part of our Commercial Sales Team, managing key health system relationships and closing complex deals, while collaborating across departments and shaping the product roadma...
1 month ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.