Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Technical Program Management, Ad Tech
$162K - $228K *
Transform the Ad Tech landscape by leading cross-functional teams to ensure seamless delivery and execution of complex technology portfolios, driving strategic initiatives and fostering collaboration...
1 week ago
Assistant Director of Nursing (ADON) - RN - Full-Time
$81K - $81K *
Elevate the quality of care by guiding nursing teams, ensuring compliance, and enhancing clinical practices. Collaborate with leadership to develop policies and provide training, fostering a culture o...
Today
Assistant Director of Nursing (ADON) - RN - Full-Time
$72K - $93K *
Partner with us to enhance nursing leadership by guiding clinical practices, training staff, and ensuring compliance with regulations. Play a key role in delivering high-quality care and supporting a...
3 weeks ago
Senior QA Analyst, Privileged Access Management
$110K - $130K *
Join us to validate complex workflows in Privileged Access Management, ensuring high standards for reliability and security across cloud integrations and enterprise environments. Collaborate with engi...
Reposted 3 weeks ago
Senior Oncology Account Manager, San Diego
$150K - $230K *
Transform oncology care by driving product adoption and building relationships with key stakeholders. Leverage your expertise to exceed performance goals and ensure patient access to innovative therap...
1 week ago
Associate Director, Clinical Trial Management - Full-Service
$120K - $150K *
Elevate your career by leading clinical trial management teams, ensuring quality and compliance in monitoring strategies. Collaborate with cross-functional teams to optimize clinical operations and dr...
1 week ago
$180K - $220K *
Unlock your potential by driving enterprise growth in healthcare. Join a dynamic team focused on building relationships with health systems and provider organizations, leveraging a robust support engi...
1 week ago
California Collaborating Psychiatrist (Clinical & Supervisory Role)
$210K - $250K *
Join a dynamic mental health team as a Collaborating Psychiatrist, providing clinical oversight and direct patient care. Engage in meaningful collaboration with PMHNPs while ensuring compliance and de...
2 weeks ago
Director, Strategic Advisory Services - Theranostics, Radiopharmaceuticals, and Oncology
$156K - $235K *
Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...
6 days ago
$95K - $115K *
Shape the future of IT capacity management by ensuring resources meet business demand in a regulated environment. Collaborate with teams to optimize performance, manage risks, and align strategies for...
Reposted 3 weeks ago
Senior Consultant, Advisory Services
$90K - $150K *
Elevate healthcare performance by leading analytics-driven consulting engagements. Collaborate with clients to identify needs, deliver insights, and implement solutions while managing project economic...
4 weeks ago
RN Operations Manager, One Medical Operations , Virtual Care Operations
$74K - $129K *
Elevate healthcare delivery by managing operations for a nationwide virtual medical team. Collaborate with leaders to optimize patient care, drive performance improvements, and implement innovative wo...
2 weeks ago
$100K - $120K *
Join a team that's driving innovative marketing strategies to enhance brand growth and engagement. You'll lead a small team, manage multi-channel campaigns, and collaborate with operations to elevate...
2 weeks ago
Senior Clinical/Operations Internal Monitoring Manager
$129K - $168K *
Optimize internal monitoring processes by leading clinical evaluations and audits across operational functions. Drive compliance, enhance decision-making, and foster team development to ensure alignme...
Yesterday
$78K - $108K *
Empower our growth by managing and negotiating sales contracts, collaborating with cross-functional teams to ensure compliance and efficiency. Your expertise will drive impactful solutions in a dynami...
Yesterday
Senior Coding Compliance Auditor - Inpatient
$76K - $131K *
Elevate healthcare compliance by leading detailed coding audits, mentoring auditors, and implementing action plans. Drive innovation and ensure adherence to standards while fostering a culture of cont...
3 weeks ago
$95K - $110K *
Discover user needs and drive product decisions as a UX Researcher, collaborating with cross-functional teams to conduct research, usability studies, and synthesize insights that enhance user experien...
2 days ago
Sr Regional Oncology Business Manager, Nashville
$130K - $160K *
Unlock potential by driving sales and education in oncology medical devices. Collaborate with healthcare professionals to enhance treatment options for liver and pancreatic cancer while achieving regi...
1 week ago
Head of Clinical Quality and Regulatory
$208K - $220K *
Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...
1 week ago
Registered Nurse (RN) Case Manager | Avera Health Plans Medical Management
$64K - $96K *
Lead the charge in providing comprehensive case management for chronic conditions, collaborating with healthcare teams to optimize care plans and improve patient outcomes in a cost-effective manner, i...
Reposted 6 days ago
$110K *
Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...
Reposted 3 days ago
Senior Director, European Regulatory Strategy Lead
$160K - $259K *
Champion regulatory excellence by leading European strategies for innovative therapies. Drive successful submissions and interactions with health authorities, ensuring compliance and alignment across...
2 weeks ago
Senior Vice President, Payer Sales
$225K - $250K *
Elevate your career by leading payer sales strategy and team development, driving new business opportunities in healthcare technology. Collaborate with executives to enhance performance and deliver im...
2 weeks ago
$80K - $95K *
Help us manage diverse projects that drive strategic growth and collaboration across teams. As a key member of the EPMO, you'll ensure project success through effective stakeholder management and cont...
6 days ago
Global Quality Assurance Auditor, Pharmacovigilance
$102K - $153K *
Champion compliance and quality assurance in the Pharmaceutical Diagnostics sector. Drive audits, analyze trends, and support regulatory inspections to enhance operational excellence and ensure adhere...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.