Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Manager, Product Management - Provider Contracting, Credentialing & Network
$108K - $180K *
Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...
3 days ago
Senior Oncology Account Manager, New Orleans
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with key stakeholders. Drive performance goals, manage territory effectively, and ensure patient access to treatments while e...
1 week ago
$100K - $122K *
Unlock your potential as you lead financial planning, analytics, and strategic initiatives. Collaborate closely with executives to drive performance improvements and optimize resource allocation, fost...
Reposted 2 weeks ago
Senior Market Research Consultant
$84K - $152K *
Unlock potential by driving strategic initiatives across marketing, product development, and operations. Collaborate with leadership and teams to identify performance gaps and translate data into acti...
1 week ago
Mental Health Therapist - Full-Time Telehealth
$70K - $92K *
Elevate mental health care by providing evidence-based therapy via video sessions. Manage diverse client needs while utilizing innovative digital tools for enhanced outcomes. Collaborate with peers in...
Yesterday
Senior Oncology Account Manager, Dallas West
$150K - $230K *
Pioneer innovative oncology solutions by building strong relationships with key stakeholders, driving product adoption, and exceeding performance goals in a dynamic biopharma environment focused on pa...
Reposted 1 week ago
Associate Director, AI Foundations Engineering (3 Openings)
$145K - $270K *
Drive the future of AI as you lead the engineering strategy for a cutting-edge platform. Collaborate across teams to design scalable, intelligent systems that enhance workflows and deliver impactful b...
4 weeks ago
Associate Director, Medical Affairs- Hematology (northern CA/Nevada)
$176K - $287K *
Lead the charge in advancing scientific discourse by engaging KOLs and HCPs in Hematological Malignancies. Drive strategic medical initiatives while fostering relationships to enhance research and cli...
4 weeks ago
Senior Clinical Database Programmer - eCOA
$110K - $140K *
Champion the design and execution of eCOA studies, ensuring compliance and data integrity. Collaborate with cross-functional teams to deliver high-quality clinical outcomes while managing multiple pro...
2 days ago
Analyst, Financial Planning & Analysis
$108K - $148K *
Join us as a Senior FP&A Analyst to drive financial planning, reporting, and forecasting. Collaborate across teams to optimize spending and enhance our financial systems, leveraging AI for insights th...
2 weeks ago
RN - Oncology Clinical Research Coordinator
$64K - $96K *
Join a dynamic team to coordinate clinical research studies, ensuring compliance and quality patient care throughout all phases of cancer treatment. Collaborate with diverse stakeholders to enhance tr...
Yesterday
Regional Sales Director - St. Louis
$180K - $215K *
Tackle the challenge of launching a groundbreaking product by leading a high-performing sales team, driving regional execution, and fostering key customer relationships in a dynamic, fast-paced enviro...
1 week ago
Complex Pediatric Clinical Psychologist
$80K - $95K *
Transform pediatric care by integrating psychological services within a dynamic, interdisciplinary team. Collaborate with healthcare professionals to support children and families, addressing emotiona...
4 weeks ago
Senior Director, Quality Assurance (Remote)
$225K - $275K *
Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...
Reposted 3 days ago
Software Engineer/Sr Software Engineer
$120K - $170K *
Develop and enhance Python services for pharmacy claims processing. Collaborate across teams to deliver high-quality solutions while gaining expertise in the pharmacy benefits domain. Embrace a hybrid...
3 weeks ago
Vice President of Product Management
$235K - $265K *
Champion product innovation by leading a dynamic team to define strategy, drive decisions, and ensure successful launches that align with company growth and customer needs in the health technology sec...
3 weeks ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | South Dakota | Telehealth
$80K - $100K *
Transform the way we deliver mental health care to older adults through evidence-based teletherapy. Join a supportive team that prioritizes your autonomy and growth while you manage personalized treat...
1 month ago
$170K - $200K *
Unlock potential by designing and building innovative billing systems that simplify financial transactions and maximize reimbursements, while leveraging AI to enhance efficiency and user experience in...
2 weeks ago
$76K - $96K *
Join a team that's dedicated to transforming healthcare through compassionate nursing. As a vital member, you'll provide high-quality patient care, collaborate with interdisciplinary teams, and thrive...
1 week ago
$76K - $96K *
Transform patient care by delivering compassionate, professional nursing services. Collaborate with interdisciplinary teams, utilize advanced clinical practices, and advocate for patients to ensure qu...
1 month ago
Laboratory Sales Specialist | Enterprise Lab
$71K - $118K *
Accelerate progress at client relationships by driving sales growth, consulting on laboratory services, and exceeding targets to enhance patient care. Collaborate effectively with stakeholders while m...
Reposted 1 month ago
EHR Application Principal Trainer
$67K - $100K *
Develop and deliver role-based training for EHR applications, ensuring curriculum accuracy and effectiveness. Collaborate with teams to optimize training environments and support user engagement in he...
1 week ago
Bioanalytical Technical Proposal Manager
$100K - $120K *
Shape the future of technical proposals by collaborating with cross-functional teams to create compelling, scientifically accurate documents that meet client needs and drive business success in the li...
1 week ago
Principal Scientist/Associate Director, Translational Medicine
$190K - $210K *
Collaborate with cross-functional teams to drive clinical biomarker strategy and execution, translating discovery insights into actionable approaches that enhance patient outcomes in early neuroscienc...
1 week ago
$92K - $138K *
Join our team to lead the Virtual Utilization Management Program, ensuring clinical excellence and operational efficiency. Collaborate with diverse healthcare professionals to enhance patient care and...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.