Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$108K - $180K *

Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Champion the promotion of oncology products, building strong relationships with key stakeholders. Drive performance goals, manage territory effectively, and ensure patient access to treatments while e...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $122K *

Unlock your potential as you lead financial planning, analytics, and strategic initiatives. Collaborate closely with executives to drive performance improvements and optimize resource allocation, fost...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$84K - $152K *

Unlock potential by driving strategic initiatives across marketing, product development, and operations. Collaborate with leadership and teams to identify performance gaps and translate data into acti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $92K *

Elevate mental health care by providing evidence-based therapy via video sessions. Manage diverse client needs while utilizing innovative digital tools for enhanced outcomes. Collaborate with peers in...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Pioneer innovative oncology solutions by building strong relationships with key stakeholders, driving product adoption, and exceeding performance goals in a dynamic biopharma environment focused on pa...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$145K - $270K *

Drive the future of AI as you lead the engineering strategy for a cutting-edge platform. Collaborate across teams to design scalable, intelligent systems that enhance workflows and deliver impactful b...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$176K - $287K *

Lead the charge in advancing scientific discourse by engaging KOLs and HCPs in Hematological Malignancies. Drive strategic medical initiatives while fostering relationships to enhance research and cli...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $140K *

Champion the design and execution of eCOA studies, ensuring compliance and data integrity. Collaborate with cross-functional teams to deliver high-quality clinical outcomes while managing multiple pro...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $148K *

Join us as a Senior FP&A Analyst to drive financial planning, reporting, and forecasting. Collaborate across teams to optimize spending and enhance our financial systems, leveraging AI for insights th...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$64K - $96K *

Join a dynamic team to coordinate clinical research studies, ensuring compliance and quality patient care throughout all phases of cancer treatment. Collaborate with diverse stakeholders to enhance tr...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$180K - $215K *

Tackle the challenge of launching a groundbreaking product by leading a high-performing sales team, driving regional execution, and fostering key customer relationships in a dynamic, fast-paced enviro...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform pediatric care by integrating psychological services within a dynamic, interdisciplinary team. Collaborate with healthcare professionals to support children and families, addressing emotiona...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$225K - $275K *

Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...

United StatesRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $170K *

Develop and enhance Python services for pharmacy claims processing. Collaborate across teams to deliver high-quality solutions while gaining expertise in the pharmacy benefits domain. Embrace a hybrid...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$235K - $265K *

Champion product innovation by leading a dynamic team to define strategy, drive decisions, and ensure successful launches that align with company growth and customer needs in the health technology sec...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$80K - $100K *

Transform the way we deliver mental health care to older adults through evidence-based teletherapy. Join a supportive team that prioritizes your autonomy and growth while you manage personalized treat...

South Dakota, USRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $200K *

Unlock potential by designing and building innovative billing systems that simplify financial transactions and maximize reimbursements, while leveraging AI to enhance efficiency and user experience in...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$76K - $96K *

Join a team that's dedicated to transforming healthcare through compassionate nursing. As a vital member, you'll provide high-quality patient care, collaborate with interdisciplinary teams, and thrive...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$76K - $96K *

Transform patient care by delivering compassionate, professional nursing services. Collaborate with interdisciplinary teams, utilize advanced clinical practices, and advocate for patients to ensure qu...

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$71K - $118K *

Accelerate progress at client relationships by driving sales growth, consulting on laboratory services, and exceeding targets to enhance patient care. Collaborate effectively with stakeholders while m...

RemoteRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Develop and deliver role-based training for EHR applications, ensuring curriculum accuracy and effectiveness. Collaborate with teams to optimize training environments and support user engagement in he...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Shape the future of technical proposals by collaborating with cross-functional teams to create compelling, scientifically accurate documents that meet client needs and drive business success in the li...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$190K - $210K *

Collaborate with cross-functional teams to drive clinical biomarker strategy and execution, translating discovery insights into actionable approaches that enhance patient outcomes in early neuroscienc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$92K - $138K *

Join our team to lead the Virtual Utilization Management Program, ensuring clinical excellence and operational efficiency. Collaborate with diverse healthcare professionals to enhance patient care and...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.