Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$108K - $149K *

Advance the organization by establishing robust data and AI governance practices. Collaborate across teams to ensure compliance, integrity, and responsible usage of data and AI assets, supporting both...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Lead the charge in driving enterprise growth within healthcare by building relationships with national and regional health plans. Own new logo acquisition and expansion, leveraging a robust support sy...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$121K - $182K *

Manage clinical monitoring activities for multiple trials, providing mentorship and oversight to CRAs. Collaborate with teams to ensure compliance and quality, while addressing site-level issues and e...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Shape the future of healthcare by leading a dynamic sales team to forge vital partnerships with medical providers, enhancing patient access to behavioral health services through innovative strategies...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$176K - $230K *

Lead the charge in transforming healthcare through data-driven solutions. As a Senior Data Scientist, you'll spearhead projects that enhance patient outcomes, leveraging your expertise to align data s...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in enhancing enterprise-wide Business Continuity programs, ensuring critical healthcare services remain uninterrupted. Collaborate across teams to strengthen resilience and deliver mea...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $212K *

Pioneer innovative IAM strategies to enhance security across cloud and on-premise infrastructures. Collaborate with cross-functional teams to implement robust identity governance and access management...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$70K - $115K *

Empower your career by joining a dynamic team focused on healthcare compliance auditing. Utilize your analytical skills to drive impactful audits and contribute to client deliverables while receiving...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$174K - $374K *

Inspire health and wellness by conducting in-home evaluations, building relationships, and bridging care gaps. Travel extensively to provide personalized health assessments, ensuring comprehensive sup...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$69K - $125K *

Lead the charge in crafting high-quality proposals and managing complex RFP processes while ensuring alignment with customer specifications and company standards under tight deadlines...

United StatesRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join us to independently manage field service activities, ensuring the reliability and performance of life-saving medical devices. This role requires significant travel and offers the opportunity to m...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Champion the installation, maintenance, and repair of life-saving medical devices. Manage service activities independently within a designated region, ensuring compliance and customer satisfaction thr...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Engage in driving revenue growth by targeting key enterprise accounts, leveraging your expertise in digital transformation and customer experience to foster relationships and secure large contracts in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Accelerate progress at driving strategic M&A initiatives by managing deal execution, from financial modeling to synergy analysis, while collaborating with senior leadership and ensuring organized proc...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$155K - $175K *

Empower healthcare professionals by delivering scientific insights and fostering relationships. Drive prelaunch and launch strategies in a dynamic environment, ensuring clinical readiness and impactfu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $160K *

Accelerate progress at a dynamic tech firm by owning the full sales cycle for mid-market practices. Collaborate with leadership to shape strategy and drive impactful relationships, ensuring success in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $110K *

Analyze and support value-based care initiatives, developing innovative forecasting solutions and methodologies. Collaborate across teams to translate complex data into actionable insights that guide...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $180K *

Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Champion the promotion of oncology products, building strong relationships with key stakeholders. Drive performance goals, manage territory effectively, and ensure patient access to treatments while e...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $122K *

Unlock your potential as you lead financial planning, analytics, and strategic initiatives. Collaborate closely with executives to drive performance improvements and optimize resource allocation, fost...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$84K - $152K *

Unlock potential by driving strategic initiatives across marketing, product development, and operations. Collaborate with leadership and teams to identify performance gaps and translate data into acti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $92K *

Elevate mental health care by providing evidence-based therapy via video sessions. Manage diverse client needs while utilizing innovative digital tools for enhanced outcomes. Collaborate with peers in...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Pioneer innovative oncology solutions by building strong relationships with key stakeholders, driving product adoption, and exceeding performance goals in a dynamic biopharma environment focused on pa...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$145K - $270K *

Drive the future of AI as you lead the engineering strategy for a cutting-edge platform. Collaborate across teams to design scalable, intelligent systems that enhance workflows and deliver impactful b...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$176K - $287K *

Lead the charge in advancing scientific discourse by engaging KOLs and HCPs in Hematological Malignancies. Drive strategic medical initiatives while fostering relationships to enhance research and cli...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.