Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$100K - $120K *
Unlock potential by delivering comprehensive health assessments in patients' homes. This role requires extensive travel within a region, ensuring quality care and education while collaborating with he...
2 weeks ago
$100K - $120K *
Drive comprehensive health assessments by traveling to patients' homes, ensuring accurate documentation and patient education. Collaborate with healthcare teams to enhance care continuity while managi...
2 weeks ago
Manager of Provider Network and Pricing Strategy
$95K - $115K *
Drive provider network excellence by managing data integrity, overseeing contract configurations, and leading cross-functional teams to enhance operational efficiency and compliance in a dynamic TPA e...
1 week ago
Manager, Market Access and Reimbursement - North Central
$136K - $170K *
Partner with us to enhance patient access by leading market access strategies, educating teams, and collaborating across departments to ensure effective reimbursement for our innovative medical techno...
4 weeks ago
$80K - $95K *
Transform credentialing operations by leading a dedicated team to ensure compliance, enhance efficiency, and support provider network growth through strategic oversight and process improvement initiat...
2 weeks ago
Senior Statistical Programmer Analyst - T
$136K - $239K *
Unlock your potential by leading statistical programming efforts in clinical trials. Collaborate with cross-functional teams to analyze and report clinical data, ensuring compliance with industry stan...
2 weeks ago
Regulatory Strategy Consultant
$125K - $150K *
Drive regulatory strategy across major programs, leading high-impact submissions and authority engagement. Collaborate with cross-functional teams to optimize clinical development and ensure complianc...
2 weeks ago
Manager, Product Trainer Neuro - Immunology- Multiple Positions
$126K - $234K *
Unlock potential by designing and delivering innovative training solutions for customer-facing teams, enhancing product knowledge and engagement skills across diverse therapeutic areas and roles...
1 week ago
$105K - $130K *
Join a dynamic team to lead multiple client engagements, driving innovative solutions and strategic direction. Foster cross-functional collaboration in a fast-paced environment with a focus on deliver...
Reposted 1 week ago
Senior Enterprise Relationship Manager
$100K - $120K *
Manage a portfolio of strategic enterprise clients, fostering executive relationships and driving retention and adoption. Utilize data and AI tools to enhance client value, mentor team members, and sh...
2 weeks ago
Application Analyst, PB Claims and Remittance
$80K - $95K *
Manage and optimize Epic Professional Billing workflows, focusing on Claims and Remittance. Serve as a key resource for end-users, troubleshooting issues and enhancing billing processes to ensure accu...
3 weeks ago
$150K - $180K *
Lead Corporate FP&A initiatives, driving budgeting, forecasting, and performance management. Oversee financial analysis and reporting while enhancing systems and dashboards for improved decision-makin...
2 weeks ago
$205K - $240K *
Shape the future of oncology as a Senior Medical Science Liaison, creating impactful scientific engagement within hematology and oncology that enhances patient care. Collaborate with KOLs and cross-fu...
Reposted 1 week ago
$100K - $120K *
Lead the charge in directing clinical rehabilitation operations across multiple practices, ensuring quality patient care and achieving financial and operational objectives through effective management...
Today
$100K - $120K *
Lead the charge in enhancing rehabilitation operations across multiple facilities. Drive clinical excellence, manage staff, and ensure compliance while fostering a supportive environment for both pati...
3 weeks ago
$80K - $95K *
Engage in high-quality legal research to support law firm clients, focusing on intellectual property matters. Utilize advanced research tools to deliver accurate results and synthesize findings into a...
3 weeks ago
Senior Oncology Account Manager, Dallas East
$150K - $230K *
Accelerate your career by driving oncology product success and building impactful relationships with healthcare professionals. Lead strategic initiatives to enhance patient access and deliver innovati...
1 week ago
$105K - $130K *
Elevate patient care by managing clinical support for monitoring systems. Lead diverse teams to enhance customer relationships and ensure effective product utilization post-implementation, driving cli...
Reposted yesterday
$80K - $95K *
Optimize your career as a Financial Analyst, driving category P&L management, revenue forecasting, and strategic financial insights. Collaborate with cross-functional teams to enhance decision-making...
Yesterday
$72K - $90K *
Lead data-driven insights to enhance business performance, collaborating across teams to support strategic initiatives. Utilize technical skills in SQL, Python, and data visualization to drive impactf...
4 weeks ago
$110K - $130K *
Join a team that's dedicated to driving growth in healthcare accounts. Leverage your strategic sales expertise to build relationships, identify opportunities, and deliver value in a fast-paced environ...
Yesterday
$110K - $130K *
Join a team that's leading Medicaid programs and initiatives, driving operational excellence and policy implementation while managing multidisciplinary teams and enhancing organizational performance a...
2 weeks ago
Medical Review Nurse - Commercial DME Auditor
$80K - $95K *
Transform healthcare auditing by conducting thorough medical claims reviews. Collaborate with a dynamic team to ensure compliance and improve processes while working remotely in a fast-paced environme...
1 week ago
Global Value and Access Senior Manager - Rare Disease
$120K - $150K *
Drive global access strategies for an innovative rare disease treatment, collaborating across teams to enhance payer insights and develop impactful materials. Lead initiatives that shape market entry...
Yesterday
Field Clinical Applications Specialist
$90K - $110K *
Elevate your career by providing expert support in molecular diagnostics, driving product implementation, and fostering strong relationships with clinical laboratories to ensure successful adoption an...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.