Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Oncology Account Manager, Los Angeles Central
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...
1 week ago
Director, Clinical Research and Cancer Center Advisory Services
$175K - $200K *
Drive impactful change in healthcare consulting by leveraging your expertise in clinical operations and research administration. Collaborate with executive leaders to solve complex challenges and fost...
3 weeks ago
$112K - $140K *
Transform your career by leading claims advocacy efforts, managing complex coverage issues, and providing expert guidance to brokers and clients. Collaborate with teams to ensure positive outcomes and...
3 weeks ago
$90K - $110K *
Accelerate program implementation and stakeholder engagement in pharmaceutical market access. Oversee daily operations, client relations, and staff management while ensuring adherence to budgets and p...
Reposted 3 weeks ago
Associate Manager, Clinical Claims
$109K - $136K *
Drive accurate, evidence-based clinical claims while collaborating with Marketing, Legal, and Clinical teams. Build and manage the claims framework and evidence library to support bold, compliant mark...
2 weeks ago
Senior Analyst, Marketing Operations
$72K - $113K *
Deliver impactful insights by owning our marketing tech ecosystem, maximizing HubSpot and Salesforce integration, and ensuring data integrity. Collaborate across teams to translate needs into actions...
Reposted 4 weeks ago
Quality Compliance & AI Operations Analyst
$80K - $90K *
Advance quality assurance initiatives and optimize workflows in a remote healthcare contact center. Collaborate cross-functionally to enhance compliance, improve patient outcomes, and drive continuous...
6 days ago
$135K - $155K *
Explore a pivotal role in shaping client relationships and driving agency success. Lead complex projects, mentor teams, and leverage your marketing expertise to deliver impactful solutions in a dynami...
1 week ago
$126K - $154K *
Unlock your potential as a Senior Accountant, driving financial accuracy and compliance. Collaborate across teams to enhance systems, oversee key accounting functions, and support audits in a dynamic...
1 week ago
RN - Full Time PMs - SF Village
$70K - $99K *
Join a team that's dedicated to providing exceptional nursing care to residents. Utilize your expertise in assessment, planning, and implementation to enhance patient outcomes in a supportive long-ter...
Reposted 3 weeks ago
$155K - $185K *
Partner with us to lead high-impact projects in healthcare marketing, managing budgets and teams while ensuring creative excellence and strategic alignment. Drive client success through collaboration...
Today
$68K - $105K *
Help us lead enterprise-wide incident responses and internal investigations into misconduct, ensuring compliance and effective fraud detection while collaborating across departments to uphold organiza...
Reposted today
$110K - $182K *
Transform laboratory services by providing expert clinical consultation, enhancing service delivery, and fostering collaboration with healthcare professionals to meet strategic healthcare goals...
1 month ago
$110K - $130K *
Drive go-to-market strategy for AI-powered healthcare solutions, collaborating cross-functionally to enhance product positioning, messaging, and performance. Own marketing execution and leverage insig...
1 week ago
Senior Advisor, Clinical Science (remote)
$168K - $283K *
Lead the charge in advancing early-stage clinical trials for innovative Orexin-targeted therapies. Collaborate cross-functionally to shape scientific strategy, drive execution, and ensure high-quality...
2 weeks ago
Senior Advisor, Clinical Science (remote)
$153K - $268K *
Transform clinical science in late-stage trials for innovative sleep/wake therapies. Collaborate cross-functionally to ensure compliance, drive recruitment, and deliver high-quality results while shap...
2 weeks ago
Psychiatric Complaints and Grievances Specialist (Remote)
$80K - $95K *
Lead the clinical review and resolution of psychiatric complaints, enhancing care quality across the network. Collaborate with clinical teams, investigate cases, and provide direct patient care, ensur...
2 weeks ago
$168K - $231K *
Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...
1 week ago
Hemostasis Sales Specialist - East Texas Region
$99K - $136K *
Join a dynamic team as a strategic growth architect, driving revenue and market share expansion in the Hemostasis portfolio. Leverage your expertise in complex healthcare sales to influence decision-m...
2 weeks ago
Integrated Solution Strategy Director - Oncology
$135K - $160K *
Join us to lead Oncology integrated solutions, collaborating across teams to design and implement strategic, client-focused approaches. Shape impactful proposals that drive growth and enhance patient...
1 month ago
Senior Consultant - HHS Collaboratives
$90K - $150K *
Lead the charge in transforming healthcare systems through data-driven insights and collaborative engagement. Drive performance improvement by managing analytics projects, delivering client solutions...
3 days ago
$95K - $115K *
Unlock potential by managing and optimizing project-level agreements, ensuring compliance and efficiency in contracting processes while supporting global operations and client needs in a dynamic legal...
1 week ago
Senior Business Systems Architect
$167K - $183K *
Lead the charge in optimizing G&A technology solutions, enhancing business processes through AI and automation. Collaborate with stakeholders to drive efficiency and compliance, ensuring scalable grow...
3 weeks ago
Senior Project Manager, Promotional Medical Education
$90K - $100K *
Accelerate progress at a dynamic agency by leading complex client campaigns. Manage project scope, timelines, and budgets while collaborating with cross-functional teams to deliver high-quality result...
Reposted 1 week ago
Behavioral Health Medical Director
$223K - $313K *
Shape the future of behavioral health care strategy and operations. Leverage your medical expertise to enhance quality, operational efficiency, and patient outcomes while navigating complex regulatory...
Reposted yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.