Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Disease Area Strategy Lead - General Medicine
$195K - $265K *
Lead the strategic direction of General Medicine, integrating scientific and commercial insights to drive portfolio decisions and early pipeline projects, while fostering cross-functional collaboratio...
3 weeks ago
Medical Advocacy & Medical Education Director
$203K - $253K *
Strategize and lead patient advocacy and medical education initiatives, fostering collaboration with stakeholders to enhance patient engagement and inform Medical Affairs strategies. Drive impactful i...
6 days ago
Associate/Sr. Associate, Academic Partnering, Asset Acquisition
$130K - $150K *
Advance innovative therapeutic programs targeting genetically driven diseases through strategic sourcing, relationship building, and cross-functional collaboration, ensuring a patient-first approach i...
Yesterday
$80K - $95K *
Drive revenue cycle operations by managing processes from entry to adjudication. Lead teams, implement efficiencies, and ensure compliance while optimizing cash collections and performance metrics for...
Reposted 3 days ago
Senior Project Manager (Neuroscience)
$122K *
Elevate your career by managing global projects in Neuroscience, ensuring compliance, budget adherence, and successful collaboration across cross-functional teams to drive milestone achievement and en...
Reposted 3 weeks ago
$94K - $169K *
Transform AI product strategies by leading cross-functional teams to identify, evaluate, and implement solutions that enhance clinical and operational workflows, ensuring alignment with institutional...
3 weeks ago
Director, Translational Pharmacokinetics - DMPK
$177K - $283K *
Unlock potential by leading pharmacokinetic modeling for early-stage drug development. Collaborate with cross-functional teams to enhance drug absorption, distribution, metabolism, and excretion (ADME...
1 week ago
Registered Nurse (RN) | Emergency Unit
$67K - $100K *
Transform patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure optimal health outcomes while providing emotional and spir...
1 week ago
$136K - $187K *
Lead patient education and support initiatives for individuals affected by generalized Myasthenia Gravis. Collaborate with caregivers and healthcare teams to enhance treatment coordination and empower...
6 days ago
$120K - $160K *
Drive WellTheory's growth in benefits consulting by cultivating strong partnerships, educating consultants, and supporting client strategies. This hands-on, individual contributor role requires strate...
Reposted 4 weeks ago
Interventional Clinical Consultant-East
$110K - $130K *
Serve as a clinical and technical leader, influencing decision-makers and supporting product innovation in interventional healthcare. Engage with key stakeholders and showcase advanced solutions to en...
Yesterday
Account Specialist (Macon, GA)
$160K - $192K *
Inspire commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful re...
5 days ago
Senior Compliance Analyst (Compliance Oversight Activities) - Remote
$74K - $118K *
Elevate compliance standards by leading oversight initiatives, managing complex projects, and collaborating across teams to ensure regulatory adherence and effective governance in a dynamic environmen...
5 days ago
Regional Sales Director - Little Rock
$180K - $215K *
Unlock potential by leading regional sales efforts for a groundbreaking product. Drive performance through strategic execution, team leadership, and customer engagement in a fast-paced, entrepreneuria...
1 week ago
Regional Sales Director - Charlotte
$180K - $215K *
Lead regional sales initiatives, driving product launch success and team performance. Collaborate cross-functionally to execute strategies, foster customer relationships, and ensure compliance while b...
1 week ago
$110K - $130K *
Take ownership of corporate governance and entity management, ensuring compliance and efficiency across multiple subsidiaries. Support M&A and financing activities while maintaining a clean corporate...
3 weeks ago
Clinical Supply Chain Specialist
$85K - $100K *
Shape the future of clinical trials by managing supply chain activities, ensuring timely delivery of essential materials and maintaining regulatory compliance. Collaborate with diverse teams to enhanc...
1 month ago
$80K - $135K *
Advance educational research by analyzing data and synthesizing findings to enhance student access to advanced courses. Collaborate with stakeholders to design studies, build dashboards, and communica...
1 week ago
Associate Director Precision Medicine - Clinical Diagnostics
$176K - $287K *
Contribute to companion diagnostic strategy and development, leading programs from biomarker feasibility to clinical validation. Collaborate across teams to ensure diagnostics align with therapeutic m...
2 weeks ago
$85K - $100K *
Elevate healthcare interoperability by designing and supporting MEDITECH interfaces. Collaborate with teams to enhance data exchange, improve patient care, and ensure seamless integration across syste...
3 weeks ago
Clinical Operations and Analytics Consultant
$82K - $128K *
Shape data-driven strategies by developing and automating analytics solutions. Collaborate with cross-functional teams to enhance reporting capabilities and optimize operational performance in a dynam...
1 week ago
Registered Nurse (RN) | Emergency Unit
$67K - $100K *
Lead patient care by developing nursing diagnoses, coordinating interventions, and providing comprehensive support to patients and families. Collaborate with healthcare teams to ensure optimal health...
3 weeks ago
Senior/Staff AI Scientist, Antibody Design
$150K - $180K *
Transform innovative protein design through advanced AI techniques, enhancing antibody drug discovery. Collaborate across disciplines to maximize efficiency and impact, while leading research that set...
Reposted 4 weeks ago
$160K - $200K *
Join a team that's dedicated to establishing a robust Quality Management System, ensuring compliance and excellence in global clinical development and commercialization. Lead quality initiatives and f...
3 weeks ago
Senior Oncology Account Manager, Los Angeles Central
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.