Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$110K - $130K *

Shape the future of secure software development by integrating security practices into engineering workflows, building automation tools, and conducting penetration tests to identify vulnerabilities an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $250K *

Join a team that's optimizing medical cost management and driving financial performance across Commercial lines. Leverage your expertise in healthcare economics to influence strategic contracting and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$132K - $153K *

Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$154K - $196K *

Unlock potential by leading strategic government programs, managing P&L, and driving operational excellence. Oversee contract delivery, mentor staff, and foster client relationships to ensure growth a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$147K - $220K *

Champion transformative health solutions by managing key client relationships, driving sales, and collaborating across teams to enhance Verily's impact in Life Sciences. Leverage expertise to unlock n...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$200K - $300K *

Drive product strategy and lifecycle management, ensuring alignment with market needs and business growth. Lead cross-functional teams to develop, launch, and support innovative medical devices while...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$145K - $160K *

Drive innovation by building scalable data integration solutions, collaborating with cross-functional teams to enhance healthcare technology. Ensure data quality and security while optimizing performa...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Shape the future of patient care by ensuring safe and effective medication use. Collaborate with healthcare professionals to manage treatments, educate patients, and oversee pharmacy operations while...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$92K - $110K *

Provide comprehensive medical care by assessing and treating patients, collaborating with physicians, and ensuring quality health education. Contribute to patient safety and care standards while maint...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$247K - $309K *

Unlock potential by leading medical strategy for hematologic malignancies. Collaborate cross-functionally to drive evidence generation, stakeholder engagement, and launch readiness, ensuring impactful...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Join a team that's shaping evidence strategies and insights in health economics and outcomes research. Lead client engagements, oversee analytics, and drive impactful decision-making in biopharma and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead the charge in transforming IT support for healthcare centers by evaluating, planning, and executing transitions to AMSURG Managed IT Services, while architecting cloud solutions with Microsoft 36...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$78K - $107K *

Drive financial integrity by managing complex accounting tasks, preparing reports, and influencing departmental strategy. Collaborate with teams to ensure compliance and accuracy while providing valua...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Drive impactful oncology solutions by building relationships with key stakeholders. Leverage your expertise to promote innovative products, exceed performance goals, and enhance patient access while n...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$73K - $110K *

Shape the future of coding quality by overseeing audits, developing guidance, and collaborating with teams to enhance accuracy and compliance in healthcare coding practices...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Transform the landscape of dental negotiations by leading strategic partnerships with payers, optimizing contracts, and driving revenue growth through data-driven insights and collaborative execution...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$66K - $99K *

Champion patient care by utilizing your nursing expertise to lead clinical teams, coordinate care, and mentor staff. Engage in effective communication and critical thinking to enhance patient outcomes...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$116K *

Lead site activation efforts by coordinating with cross-functional teams to ensure timely and quality delivery of clinical projects. Drive strategic initiatives and mitigate risks while enhancing comm...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$250K - $300K *

Lead a dynamic team of radiologists in a remote setting, managing diverse caseloads including inpatient and outpatient cases. Enjoy a supportive culture with growth opportunities and a compensation mo...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $243K *

Deliver innovative disaster recovery solutions for healthcare systems, ensuring compliance and resilience for clinical workloads. Collaborate with cross-functional teams to address complex challenges...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$144K - $195K *

Innovate and lead the design of identity management solutions, ensuring security and integration across platforms. Collaborate with teams to enhance user experience and manage critical issues in a dyn...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive financial accuracy and compliance as a Senior Accountant. Lead month-end close, maintain internal controls, and support auditors while refining processes. Ideal for proactive self-starters seeki...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$76K - $114K *

Unlock potential by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage clinical expertise to build relationships, enhance product adoption, and ensure customer satisfacti...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$150K - $245K *

Drive the execution of companion diagnostics strategy, managing cross-functional teams and partnerships to ensure successful assay development and regulatory compliance, ultimately enhancing patient o...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Join a team that's driving regional marketing initiatives in hematology and oncology. Engage with key thought leaders, execute strategic plans, and leverage local opportunities to enhance brand presen...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.