Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Clinical Scientist (Psychiatry/Neuroscience)
$79K - $157K *
Advance clinical data insights by reviewing and analyzing trial results, collaborating with cross-functional teams to ensure data integrity, and presenting findings to stakeholders, enhancing study ou...
Reposted 1 week ago
$110K - $130K *
Champion client success by managing key relationships and driving strategic initiatives. Lead cross-functional teams to deliver high-quality work while ensuring financial performance and growth for as...
Reposted yesterday
Regional Sales Director - Richmond
$180K - $215K *
Lead the charge in driving regional sales success through strategic execution, team leadership, and cross-functional collaboration. Foster strong customer relationships and ensure alignment with corpo...
1 week ago
Account Manager, Immune Response, Clinical Sales (Chicago)
$100K - $120K *
Champion new business opportunities in the diagnostic sales sector, driving growth in non-acute care markets. Achieve sales quotas, foster client relationships, and implement innovative technologies t...
Today
$67K - $100K *
Lead the charge in delivering exceptional nursing care, developing tailored care plans, and providing holistic support to patients and families. Collaborate with healthcare teams to ensure optimal pat...
2 weeks ago
Strategic Financial Analyst - Corporate Strategy & Development
$128K - $170K *
Empower executive leadership with strategic financial insights to drive growth initiatives. Collaborate on M&A, pricing, and R&D investments while delivering actionable recommendations in a fast-paced...
Reposted 4 weeks ago
Corporate Finance Manager, Fundraising and Investor Relations
$133K - $166K *
Champion the fundraising efforts of a dynamic corporate finance team, managing complex debt and equity processes while collaborating with senior leadership to craft compelling narratives for investors...
1 week ago
$95K - $115K *
Empower our finance team by overseeing accounting operations, ensuring compliance, and enhancing financial reporting. Lead month-end close activities and mentor team members in a dynamic, multi-entity...
1 week ago
Clinical Research Associate II
$90K - $110K *
Unlock potential by overseeing clinical trials, ensuring compliance with protocols and regulations. Collaborate with investigators and coordinators to protect participant rights and verify data integr...
3 days ago
$100K - $120K *
Join a team that's transforming women's health by driving sales in OB/GYN and maternal-fetal medicine. You'll manage the full sales cycle, leveraging existing relationships to expand our reach and ens...
2 weeks ago
Account Manager- Client Success
$80K - $85K *
Grow your career with a dynamic team focused on client success, managing relationships, and delivering tailored solutions. Drive satisfaction and retention while collaborating across departments to en...
1 week ago
Medical Planner - Architecture
$70K - $135K *
Shape the future of healthcare design by collaborating with multidisciplinary teams to develop innovative planning solutions that enhance patient care and operational efficiency in medical facilities...
2 weeks ago
$225K - $250K *
Transform operations by leading a diverse team to enhance profitability and efficiency across multiple sites, while building strategic relationships with clients and driving growth initiatives in the...
1 week ago
$175K *
Champion enrollment growth by leading a high-performing team, optimizing processes, and enhancing the student experience. Collaborate cross-functionally to drive strategic initiatives and achieve meas...
Yesterday
$120K - $160K *
Analyze complex data and drive solutions as a Business Analyst in the public sector. Leverage your expertise in pension systems to identify issues and enhance processes, ensuring effective communicati...
Reposted 4 days ago
$167K - $196K *
Drive risk mitigation strategies by analyzing account takeover and scam threats. Collaborate cross-functionally to enhance user protection and platform integrity, shaping metrics and prevention tactic...
3 weeks ago
Registered Nurse (RN) | Surgery
$67K - $100K *
Optimize patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure holistic support for patients and their families. Join us i...
6 days ago
Registered Nurse (RN) | Surgery
$67K - $100K *
Elevate patient care by developing nursing diagnoses, coordinating interventions, and providing comprehensive support to patients and families. Collaborate with healthcare teams to ensure optimal heal...
6 days ago
In-Home Traveler Physician Full Time - DC
$174K - $374K *
Engage with patients in their homes to conduct health evaluations, build relationships, and bridge care gaps. This role demands extensive travel and flexibility to provide personalized care and diagno...
4 weeks ago
Principal Scientist, Biologics
$150K - $180K *
Shape the future of oncology by leading biologics process development and manufacturing. Collaborate across teams to ensure compliance and quality in clinical-stage products, while mentoring scientist...
2 weeks ago
Principal, Strategic Partnerships, Health Systems
$150K - $180K *
Unlock potential by driving partnerships within health systems, building strategic relationships, and creating impactful ecosystems that accelerate product adoption and streamline sales cycles, while...
Reposted 1 week ago
Senior Program Manager, Maternal Health
$100K - $120K *
Unlock potential by leading innovative strategies for AI-enabled maternal care. Drive program implementation, manage complex projects, and engage stakeholders to enhance health outcomes in low- and mi...
Today
Account Manager, Molecular Diagnostics, QIAstat (Midwest)
$100K - $120K *
Advance healthcare solutions by driving sales of innovative diagnostic instruments. Engage with key stakeholders to promote QIAstat-Dx systems, ensuring successful adoption and customer satisfaction t...
3 days ago
Manager, Clinical Data Management
$110K - $130K *
Innovate within a dynamic team, driving impactful projects and solutions that enhance operational efficiency and foster growth across multiple departments. Your expertise will shape strategic initiati...
Yesterday
$127K - $165K *
Unlock potential by leading regulatory strategies for innovative medical devices. Collaborate with teams to ensure compliance, execute FDA submissions, manage project timelines, and establish processe...
Reposted 5 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.