Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$95K - $110K *
Take ownership of nursing excellence by leading a dedicated team to deliver high-quality care in a supportive environment. Foster relationships and drive clinical practices while ensuring compliance w...
1 week ago
$150K - $175K *
Drive financial operations and internal controls while leading a remote accounting team. Oversee month-end closes, technical accounting, and ERP transformations to enhance operational efficiency and e...
Today
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- South Central
$76K - $114K *
Elevate the clinical sales landscape by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance product adoption, and e...
2 weeks ago
$105K - $115K *
Optimize medical device utilization in health systems by leveraging expertise in cardiovascular, interventional radiology, and general surgery. Collaborate with stakeholders to drive cost reduction an...
2 weeks ago
Provider Relations Supervisor - Dental
$55K - $109K *
Engage in leading the dental Provider Relations team, enhancing provider relationships and operational effectiveness. Drive network management activities to ensure member access to care and improve pr...
Reposted 2 weeks ago
Regional Sales Director - Knoxville
$180K - $215K *
Elevate regional sales performance by leading a high-performing team, executing launch strategies, and fostering customer relationships in a dynamic environment. Drive accountability and collaboration...
1 week ago
$80K - $95K *
Empower our rehabilitation team by leading operations, ensuring compliance, and enhancing patient care. Drive financial success and foster strong relationships with staff and clients while maintaining...
2 weeks ago
$95K - $115K *
Transform patient care by delivering comprehensive primary health services, utilizing advanced practice skills to assess, diagnose, and treat diverse health conditions while collaborating with physici...
3 weeks ago
$95K - $115K *
Transform clinical quality by supporting training initiatives, monitoring clinician performance, and ensuring compliance with quality standards for successful operational processes and clinician suppo...
Reposted 1 week ago
Registered Nurse (RN) - $5k Bonus
$66K - $99K *
Unlock potential by providing compassionate care to individuals facing substance use and mental health challenges. Join a dedicated team committed to making a difference in the community through excep...
1 week ago
Assistant Director, Global Service Delivery
$100K - $120K *
Advance global service delivery by managing offshore partnerships, ensuring performance excellence, and driving operational improvements across teams to enhance productivity and quality outcomes...
Reposted today
$75K - $90K *
Elevate patient care by preparing individuals for surgery through thorough assessments, education, and collaboration with surgical teams, ensuring a seamless and compassionate preoperative experience...
2 days ago
Account Specialist (Roseville, CA)
$160K - $192K *
Accelerate progress at driving commercial performance by engaging healthcare providers, building relationships, and supporting product launches to ensure patient access to innovative therapies across...
1 week ago
Remote Quality Improvement Data Analyst
$70K - $106K *
Transform operational data into actionable insights while collaborating with cross-functional teams to support business decisions and enhance efficiency. Leverage analytical skills to drive performanc...
Reposted 3 days ago
Clinical Development Director, Early Development Oncology
$274K - $371K *
Develop and lead early phase clinical strategies for oncology candidates, ensuring design and execution of clinical trials. Collaborate with internal teams and external experts to drive innovative dru...
Reposted 1 week ago
Clinical Project Manager - Oncology (Client Dedicated/Remote)
$120K - $135K *
Empower clinical research excellence by managing projects that ensure compliance with regulatory requirements and drive successful study delivery from initiation to closeout. Collaborate with interdis...
Reposted 3 weeks ago
Senior Engagement Manager - Medical Affairs
$210K - $258K *
Unlock your potential as a Senior Engagement Manager, leading complex consulting projects for pharmaceutical clients. Drive strategic medical initiatives, foster client relationships, and mentor teams...
Reposted 1 week ago
Senior Director, Client Success
$150K - $180K *
Reimagine client partnerships by managing complex relationships, driving performance, and leading recovery strategies. Collaborate with executives to ensure client success and identify growth opportun...
2 weeks ago
$95K - $100K *
Join a dynamic team as a Senior Strategist, where you'll lead data-driven strategies, mentor talent, and drive innovative solutions in healthcare advertising. Collaborate with creative teams to enhanc...
3 days ago
Director, Sales – Global Strategic Accounts
$150K - $180K *
Empower a high-performing sales team to drive strategic growth and customer engagement in the biopharma sector. Lead complex sales initiatives, build executive relationships, and translate business st...
Yesterday
$104K - $130K *
Empower growth by transforming complex data into actionable insights. Collaborate with senior leaders to build analytical tools and models that drive strategic decisions, while enhancing operational e...
2 days ago
$140K - $190K *
Champion healthcare transformation by leading client success initiatives across revenue cycle operations. Drive strategic improvements, foster innovation, and collaborate with executive leaders to enh...
3 weeks ago
Director, Business Strategy & Operations, Research
$192K - $288K *
Join a team that's driving strategic initiatives in Neuroscience and Oncology. In this pivotal role, you'll partner with leadership to enhance operations, manage budgets, and streamline workforce plan...
Yesterday
Director, Diagnosis-Related Group Validation (DRGV)
$125K - $150K *
Unlock your potential by leading the development of innovative DRGV services, enhancing billing and coding optimization. Collaborate across teams to create scalable solutions that drive operational ex...
2 weeks ago
Head of National Strategic Accounts
$250K - $300K *
Champion strategic growth by leading the charge to secure complex health system accounts. Drive transformative deals with hands-on coaching, leveraging deep relationships and expertise to elevate team...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.