Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$170K - $190K *

Lead the charge in advancing analytical development strategies for small molecule drug substances and products, ensuring compliance and quality across the product lifecycle while collaborating with cr...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $100K *

Inspire your career with a role supporting physicians and enhancing patient recovery through hands-on medical care, assessments, and collaboration in a dynamic healthcare environment...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$140K - $180K *

Shape the future of clinical quality assurance by overseeing trials, ensuring compliance with GCP and ICH standards, and driving operational excellence across clinical activities within a cross-functi...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $195K *

Innovate member experience strategies by translating enterprise goals into actionable plans. Drive performance improvements in CAHPS and HOS programs through provider engagement and data analysis, ens...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$175K - $205K *

Transform client relationships and drive growth by leading strategic initiatives in scientific visualization, medical education, and digital engagement. Manage multidisciplinary teams and oversee acco...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$83K - $103K *

Drive success in regulatory affairs by preparing critical submissions for medical and diagnostic devices. Oversee compliance with U.S. and international regulations while collaborating with cross-func...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Execute territory business plans to drive commercial performance, engage healthcare providers, and support product launches. Collaborate with cross-functional teams to optimize patient access and ensu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Lead corporate legal strategy and M&A transactions, guiding complex deals and governance. Manage a growing legal team, develop processes, and partner with senior leadership to drive business initiativ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$193K - $308K *

Join a team that's redefining statistical leadership in clinical research. Drive innovative study designs, enhance drug development effectiveness, and influence critical decisions through data-driven...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$60K - $250K *

Drive impactful connections in healthcare by matching providers with facilities. Leverage your sales expertise to build relationships, negotiate contracts, and contribute to a rewarding mission that e...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $140K *

Grow your career with a dynamic role in clinical support, training surgical teams, and ensuring optimal patient outcomes in complex procedures. Collaborate closely with medical professionals, manage i...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $149K *

Drive strategic payer partnerships and enhance revenue cycle performance through oversight, mentorship, and data analysis. Collaborate across teams to resolve complex issues and improve operational ef...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Champion patient safety by monitoring neuromuscular function during surgeries. Collaborate with surgical teams to ensure optimal outcomes through real-time data analysis and communication, making a si...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$162K - $224K *

Drive growth in the Neurodegenerative Disease sector by developing strategic partnerships with health systems and academic centers, leveraging existing relationships to create innovative solutions tha...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$285K - $310K *

Lead the strategic execution of global clinical trials, ensuring adherence to timelines, budgets, and quality standards while fostering collaboration across teams and mentoring Clinical Operations per...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Advance your career by driving business development in clinical research and medical imaging. Build strategic client relationships, identify new opportunities, and contribute to innovative healthcare...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Champion the development and oversight of scientific content across diverse therapeutic areas while managing client relationships and brand strategy for multiple accounts, ensuring high-quality and im...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$130K - $150K *

Shape the future of healthcare technology by leading clinical strategy initiatives to enhance drug diversion prevention and ensure patient privacy compliance. Drive impactful relationships, educate st...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$187K - $234K *

Join a team that's dedicated to ensuring the safety and effectiveness of cancer treatments. Utilize your expertise in medical physics to conduct quality assurance, develop clinical protocols, and supp...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$210K - $230K *

Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $110K *

Take ownership of nursing excellence by leading a dedicated team to deliver high-quality care in a supportive environment. Foster relationships and drive clinical practices while ensuring compliance w...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$76K - $114K *

Elevate the clinical sales landscape by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance product adoption, and e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$105K - $115K *

Optimize medical device utilization in health systems by leveraging expertise in cardiovascular, interventional radiology, and general surgery. Collaborate with stakeholders to drive cost reduction an...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$55K - $109K *

Engage in leading the dental Provider Relations team, enhancing provider relationships and operational effectiveness. Drive network management activities to ensure member access to care and improve pr...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.