Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Director, Head of Analytical Development
$250K - $275K *
Transform the future of drug development by leading Analytical Development for small molecules and oligonucleotides. Drive scientific strategy, build a high-performing team, and ensure regulatory read...
2 weeks ago
Associate General Counsel, Legal (US)
$200K - $398K *
Drive impactful legal strategies in a global clinical research environment, guiding senior leadership on complex regulatory and compliance matters while fostering innovation and risk management across...
3 weeks ago
$111K - $167K *
Join a team that's driving healthcare transformation by leading client integration initiatives. Collaborate across departments to ensure seamless transitions, operational readiness, and long-term succ...
Today
Regional Director of Clinical Operations
$100K - $120K *
Shape the future of healthcare by leading clinical operations across 3-5 skilled nursing facilities in eastern South Dakota, ensuring regulatory compliance and quality care while managing multiple tea...
Reposted 1 week ago
Payer Engagement Lead - Regional Accounts
$214K - $234K *
Champion strategic payer engagement across regional markets, building relationships that enhance patient access to therapies. Connect national strategies with local execution for optimal outcomes in c...
Reposted 3 weeks ago
$160K - $190K *
Elevate healthcare solutions by transforming complex data needs into scalable systems. Collaborate with cross-functional teams to design and build data pipelines and insightful dashboards that enhance...
Reposted 2 weeks ago
Clinical Informatics & Ontology Lead
$120K - $145K *
Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...
Today
VICE PRESIDENT, OPERATIONS (SOUTHEAST)
$180K - $220K *
Drive the future of healthcare operations by leading a $300M portfolio, fostering physician partnerships, and executing growth strategies while managing financial and operational performance for a dyn...
Reposted 1 week ago
Assistant Professor, Physician Assistant
$110K - $159K *
Join us to foster an innovative educational environment, providing leadership and mentorship while enhancing curriculum and teaching methodologies to ensure student success and engagement in learning...
3 weeks ago
Staff Physician, 24/7 Care (Full-Time / 100% Remote)
$143K *
Join a team that's redefining virtual healthcare by delivering high-quality, patient-centered care. As a key member, you'll provide comprehensive virtual medical services, collaborate with stakeholder...
Yesterday
Director, Chronic Practice Liaison - Remote
$126K - $210K *
Lead strategic initiatives to enhance referral growth and provider engagement across chronic therapy markets. Drive collaboration among cross-functional teams to optimize patient progression and deliv...
3 weeks ago
$135K - $160K *
Help us shape the future of pulmonary care by leveraging your clinical expertise to drive product development, enhance workflows, and ensure effective solutions for COPD, asthma, and other pulmonary c...
1 week ago
National Medical Director, Enterprise Partnerships, Remote
$210K - $250K *
Transform healthcare delivery by leading a team of Medical Directors and Clinical Directors, driving clinical strategy and performance excellence across portfolios while fostering relationships and in...
6 days ago
MGR, Contracting - Health Plan Relations (West Region)
$95K - $115K *
Drive managed care contracting activities, supporting payer negotiations and relationships. Collaborate with leadership to execute center-level priorities and enhance client satisfaction through effec...
1 week ago
Internal Medicine or Family Medicine Physician
$241K - $337K *
Transform your career with a flexible role in primary care, serving a diverse patient population. Collaborate with a dedicated team in a supportive environment, offering both part-time and full-time o...
3 weeks ago
Clinical Oversight Manager (COM) - USA
$110K - $130K *
Accelerate progress at the forefront of clinical research by ensuring effective oversight and management of clinical studies. Collaborate with teams to uphold quality standards and drive successful st...
Yesterday
Associate Director, Clinical Solutions Engineering
$177K - $221K *
Drive the development and implementation of innovative clinical solutions, leading a technical team to deliver AI-enabled applications and analytics. Collaborate with stakeholders to ensure scalable...
Today
Clinical Pharmacist - Value Based Care
$110K - $130K *
Unlock potential by leading a remote pharmacy program focused on medication adherence. Collaborate with a specialized team to enhance patient care through data-driven strategies and operational suppor...
6 days ago
Clinical Applications Specialist
$80K - $95K *
Help us deliver exceptional training and support for medical imaging equipment, enhancing customer experiences through expertise and mentorship while traveling frequently to engage with healthcare pro...
Today
Registered Nurse (RN) | Endoscopy
$67K - $100K *
Join a team that's dedicated to delivering exceptional nursing care by developing personalized care plans, providing emotional support, and collaborating with healthcare professionals to enhance patie...
2 weeks ago
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- Midwest
$76K - $114K *
Shape the future of healthcare by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance product adoption, and ensure...
2 weeks ago
$80K - $95K *
Join a team that's redefining inpatient coding operations, ensuring quality and compliance while optimizing workflows. Lead a dedicated team to enhance documentation practices and support financial he...
2 weeks ago
Medical Education Content Manager
$85K - $115K *
Elevate healthcare education by developing evidence-based content for clinicians. Collaborate with experts to create innovative learning materials that address practice gaps and enhance professional s...
Today
$90K - $110K *
Transform complex clinical data into compelling copy that resonates. Collaborate with cross-functional teams to create impactful healthcare campaigns, ensuring accuracy and brand voice across diverse...
1 week ago
Sr. CRA, FSP - Surgical / Medical Device - Central region
$130K - $133K *
Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.