Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Assoc Dir, Neuro Thought Leader Liaison (Midwest Region)
$190K - $225K *
Transform relationships with key opinion leaders in rare neurological diseases, providing strategic insights and guidance to inform brand strategies and enhance engagement across medical and commercia...
Reposted 2 days ago
$120K - $155K *
Join a team that's dedicated to enhancing national security through expert program analysis. Leverage your extensive experience to support critical FAA initiatives, ensuring compliance and effective p...
Today
Global Safety Medical Director, Rare Disease
$256K - $347K *
Lead the charge in ensuring optimal safety standards for Rare Disease products. Establish pharmacovigilance strategies, oversee safety profiles, and engage cross-functional teams to deliver critical t...
Reposted 4 weeks ago
Senior Director, Clinical Diagnostics and Precision Medicine
$242K - $403K *
Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...
2 weeks ago
Senior Regulatory Affairs Associate - Regulatory Intelligence
$95K - $115K *
Drive regulatory intelligence initiatives to ensure compliance and support clinical research. Collaborate with experts to assess regulatory changes, track global guidelines, and enhance impact assessm...
1 week ago
$92K - $126K *
Drive innovative solutions by blending product analytics and low-code development, collaborating cross-functionally to enhance AI Agent capabilities and optimize Revenue Cycle operations within the he...
Reposted 1 week ago
Clinical Applications Specialist, Contrast Media Delivery Solutions
$100K - $150K *
Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...
2 weeks ago
Senior Director, Clinical Quality Assurance (CQA)
$245K - $286K *
Elevate clinical quality assurance through strategic leadership and oversight of global trials, ensuring compliance with GCP regulations. Drive quality culture and inspection readiness while mentoring...
Reposted 3 weeks ago
$122K *
Champion clinical excellence by leading large teams, ensuring strategic alignment, and driving patient recruitment while mitigating risks in clinical operations for successful study execution...
1 week ago
Associate Medical Director, Renal Cancer Theranostics
$175K - $210K *
Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...
2 weeks ago
VP, Sales - Global Client Services
$120K - $140K *
Transform global client relationships by driving revenue growth and strategic account management. Collaborate with C-suite executives to connect workplace culture and employee experience to measurable...
Today
$149K - $224K *
Drive analytics excellence by leading a team to deliver impactful insights, enhance reporting capabilities, and support strategic decision-making across diverse business functions. Foster collaboratio...
6 days ago
Manager, Applications, Epic Orders
$165K - $264K *
Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...
2 days ago
Specialty Development Executive - West Territory
$140K - $180K *
Advance healthcare by driving product adoption and education in colorectal cancer screening across a key geographic territory. Collaborate with healthcare providers to enhance market penetration and e...
Reposted 2 weeks ago
Global Regulatory Affairs Director - Inflammation and Rare Disease
$189K - $256K *
Join a global team to shape regulatory strategies in biotechnology, supporting product development and lifecycle management in Inflammation and Rare Diseases. Lead regulatory efforts, ensure complianc...
1 month ago
Sr. Talent Acquisition Partner
$100K - $120K *
Shape the future of executive recruitment by leading strategic sourcing, engaging high-level candidates, and collaborating with a dedicated team to uncover top talent. This role offers growth opportun...
Reposted 2 weeks ago
Senior Director, Patient Recruitment - Remote
$150K - $180K *
Inspire patient recruitment strategies by leading a dynamic team, collaborating with senior management, and leveraging innovative tools to enhance enrollment across clinical trials while ensuring dive...
1 week ago
Medical Director, Medical Affairs
$174K - $374K *
Lead the charge in clinical oversight and mentorship, driving innovative medical solutions across diverse programs. Collaborate with cross-functional teams to ensure evidence-based decision-making and...
2 weeks ago
AVP Clinical Documentation (Orchestration Works)
$150K - $250K *
Unlock potential by leading innovative clinical documentation initiatives that enhance quality, compliance, and revenue cycle outcomes. Collaborate with cross-functional teams to redefine workflows an...
1 week ago
$74K - $85K *
Lead the planning and execution of diverse research projects, ensuring alignment with organizational goals. Collaborate with stakeholders to manage timelines, deliverables, and budgets while fostering...
2 weeks ago
$100K - $160K *
Join a team that's transforming healthcare with AI solutions. As an AI Solutions Engineer, you'll develop integrations and tools that enhance customer workflows, bridging the gap between clients and o...
3 weeks ago
Clinical Development Medical Director, Early Development - Cardiometabolic
$274K - $371K *
Lead the early phase clinical development of innovative therapeutics, collaborating across teams to design and execute trials. Your expertise will directly influence strategy, protocol development, an...
Reposted 1 week ago
$140K - $170K *
Elevate your career by managing a dynamic Palliative Care Program, providing clinical expertise, and leading a dedicated team. Drive process improvements and ensure high-quality patient care while fos...
3 weeks ago
$210K - $240K *
Lead strategic relationships with influential optometrists and ophthalmologists, shaping the Presbyopia ecosystem through education and engagement. Drive insights and collaboration across medical, mar...
2 weeks ago
$80K - $110K *
Transform financial operations by providing analytical support, enhancing reporting processes, and collaborating with cross-functional teams to drive profitability and efficiency in budgeting and fore...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.