Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$92K - $167K *

Unlock potential by developing and maintaining scalable applications, integrating new technologies, and participating in Agile methodologies to enhance product features and client solutions...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Optimize your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$82K - $110K *

Champion grant proposal excellence by collaborating with clients to enhance competitiveness in scientific research funding. Drive impactful outcomes through expert consulting, training, and proposal d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Join our team to develop and implement innovative insurance and investment solutions. Contribute to the administration of stable value products while enhancing expertise and collaborating with cross-f...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$190K - $252K *

Join a team that's redefining professional coding leadership, overseeing coding operations, quality audits, and education initiatives. Drive strategic objectives that enhance patient care and revenue...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Champion the future of program financial analysis by overseeing Earned Value Management Systems, ensuring compliance and performance tracking while providing strategic financial support and insights t...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Technical Services

$74K - $87K *

Transform customer experiences by leading Unanet ERP implementations, ensuring successful configurations and training for Government Contracting clients. Manage multiple projects, driving adoption and...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $200K *

Elevate the future of travel by leading AI-driven hotel booking innovations. Collaborate closely with the CEO to shape product direction, enhance existing platforms, and build a dynamic team focused o...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$154K - $212K *

Lead the charge in engineering excellence across device product areas, managing teams and driving innovation in patient engagement technology. Collaborate closely with cross-functional teams while mai...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $150K *

Reimagine data management as a Senior Technical Product Owner, leading cross-functional teams to drive product vision and execution. Oversee complex SQL Server systems and cloud-native applications, e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$139K - $163K *

Advance your career as a strategic legal partner by providing product and privacy counsel that balances compliance with innovation. Collaborate across teams to develop scalable solutions that support...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Deliver impactful voice AI solutions by driving strategic account growth and managing complex sales cycles. Collaborate across teams to exceed sales targets while fostering relationships with key stak...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Transform complex data systems by designing and implementing scalable solutions that enhance analytics and drive business intelligence in a collaborative, Agile environment focused on healthcare compl...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$132K - $199K *

Join a team that's committed to transparency in clinical trials, ensuring compliance with global disclosure regulations. This role blends operational and strategic tasks, fostering collaboration and q...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$70K - $110K *

Unlock your potential by analyzing data and conducting audits to enhance compliance for innovative B2B and B2C platforms. Collaborate with cross-functional teams, apply critical thinking, and gain ins...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Join a team that's redefining customer success by leveraging AI to enhance the post-sale journey. Lead and scale a dynamic team while driving retention and expansion for enterprise clients in a fast-p...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$73K - $115K *

Grow your career with a dynamic team focused on optimizing provider operations. Lead credentialing initiatives, implement AI solutions, and enhance workflows while ensuring compliance and operational...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$160K - $192K *

Engage healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring compliance and lever...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$162K - $224K *

Elevate healthcare solutions by driving business development in neurodegenerative disease pathways. Collaborate with health systems and stakeholders to identify needs, develop strategies, and create i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$128K - $165K *

Empower Fraud Operations by leading AI-driven automation initiatives, enhancing investigative workflows, and delivering actionable insights to optimize fraud detection and prevention efforts across th...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Transform regulatory strategies for rare disease and cardio-pulmonary drug-device programs. Collaborate with cross-functional teams to ensure compliance and drive successful submissions globally, supp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$113K - $197K *

Lead the charge in defining product strategy and roadmap, translating business objectives into actionable plans. Collaborate with cross-functional teams to ensure successful implementation and operati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Empower your career by driving oncology product success and building impactful relationships with healthcare professionals. Lead strategic initiatives to enhance patient access and deliver innovative...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform healthcare delivery by leading program initiatives that drive partner success in value-based care. Utilize data-driven strategies to manage launch processes, ensuring alignment across teams...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.