Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$120K - $145K *

Drive system reliability and scalability as a Senior Site Reliability Engineer, focusing on automation and collaboration with software teams to enhance performance and maintain service objectives acro...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $190K *

Champion a national team of Medical Science Liaisons focused on obesity, driving strategy and KOL engagement. Lead cross-functional collaboration and ensure compliance while developing high-performing...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Partner with us to lead transformative business development initiatives in life sciences. Drive revenue through strategic engagement with pharma/biotech partners, managing the full sales cycle and ens...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Optimize market intelligence within global diagnostics by leading analytical work, synthesizing data, and translating complex insights into actionable recommendations. Collaborate with diverse stakeho...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$64K - $162K *

Drive innovative strategies to enhance visibility across Generative Engine Optimization and AI search platforms, supporting higher education clients and professional education products through data-dr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$150K - $200K *

Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$108K - $156K *

Empower your career by leading revenue analytics, overseeing financial analysis, and enhancing payer contract strategies. Collaborate with cross-functional teams to optimize reimbursement and drive or...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Oversee financial strategy and performance across multi-market healthcare services. Lead and inspire finance teams, ensuring compliance and driving operational excellence while partnering with executi...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $95K *

Transform client relationships by delivering exceptional service and support, ensuring seamless communication and issue resolution while collaborating with internal teams to enhance client satisfactio...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$165K - $194K *

Pioneer impactful scientific exchanges as a Senior Medical Science Liaison, fostering relationships with healthcare providers and key opinion leaders in hematology/oncology while supporting Rigel's in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K *

Drive enterprise-level implementations of phishing-resistant authentication solutions, leading technical deployments and integrations across various identity platforms while ensuring customer success...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$112K - $132K *

Join a team that's shaping the future of autism care by building robust statistical methodologies. You'll analyze real-world clinical data, ensuring rigorous evaluation of outcomes and social validity...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $160K *

Contribute to the evolution of data-driven healthcare products, shaping strategy and execution. Collaborate with cross-functional teams to deliver AI-enabled solutions that enhance clinical outcomes a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Elevate security observability by enhancing Datadog's capabilities across cloud and corporate environments, ensuring actionable detection aligned with real-world threats while collaborating with cross...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive the technical strategy for AI across the organization, ensuring clarity and accountability in AI investments. Collaborate with cross-functional leaders to scale impactful AI initiatives, optimiz...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $192K *

Engage with healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful relat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$106K - $160K *

Join us to define and enhance our financial data offerings, focusing on Private Markets. Collaborate with cross-functional teams to drive product strategy, close content gaps, and ensure seamless inte...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$88K - $113K *

Transform proposal management by leading cross-functional teams to deliver high-quality, compliant responses. Drive efficiency through strategic planning, risk management, and collaboration, ensuring...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$85K - $120K *

Drive excellence in network operations by providing 24/7 support, designing solutions, and ensuring compliance with security best practices. Collaborate with teams to enhance customer connectivity and...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$50K - $114K *

Transform financial operations by driving budgeting, forecasting, and reporting processes. Collaborate with stakeholders to ensure accuracy and alignment in workforce planning, while supporting leader...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Engage with key stakeholders to promote oncology products, build relationships, and drive brand value. Utilize market insights to develop effective strategies, ensuring patient access and compliance w...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$188K - $245K *

Empower innovation by leading a UX design team focused on clinical workflows. Collaborate across functions, drive strategic direction, and enhance AI integration while advancing design quality in heal...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $130K *

Manage the design and implementation of integrated physical security systems, driving innovative solutions in complex environments while fostering collaboration with clients and stakeholders for enhan...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $120K *

Accelerate client success by owning the onboarding and rollout for enterprise clients, ensuring smooth transitions from purchase to sustained usage. Collaborate with cross-functional teams to drive ad...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$222K - $278K *

Drive impactful change by consolidating technologies and digitizing workflows for enterprise customers, while fostering executive relationships and managing complex sales processes that promote safety...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.