Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$80K - $95K *

Engage with mid-sized General Contractors to drive revenue growth. Manage the full sales cycle, from outreach to contract signing, while delivering exceptional customer experiences and exceeding sales...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$155K - $175K *

Serve as a key scientific partner in the field, driving prelaunch and launch strategies through trusted relationships, high-quality exchanges, and actionable insights to enhance product adoption and c...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $147K *

Drive clinical project performance by leading teams in the execution of research trials. Collaborate with stakeholders to ensure operational excellence, manage budgets, and mitigate risks while foster...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $189K *

Elevate organizational efficiency by leading Workday Absence and Time Tracking solutions. Collaborate cross-functionally to optimize processes, ensuring compliance and enhancing user experience as the...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Engage with senior stakeholders to enhance R&D efficiency in life sciences. Drive proposals, develop strategies, and ensure quality oversight while building networks to support business development an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$117K - $146K *

Lead the charge in developing innovative algorithms and pipelines for early cancer detection, collaborating with cross-functional teams to analyze complex genomic datasets and enhance clinical diagnos...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$250K - $280K *

Shape the future of our enterprise sales segment by driving growth and account success. Take ownership of new logo acquisitions, deepen existing client relationships, and establish best practices for...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$101K - $146K *

Lead the charge in managing complex casualty claims, ensuring timely evaluations and settlements while collaborating with stakeholders to uphold coverage standards and compliance. Drive efficiency in...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$80K - $95K *

Join a team that's dedicated to enhancing healthcare quality through thorough medical claims audits. Leverage your nursing expertise in a dynamic remote environment, collaborating with experienced aud...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead feasibility strategy and execution for clinical studies, driving operational excellence and data-driven insights to optimize trial planning and enrollment across rare disease programs. Collaborat...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Empower your career by providing essential pharmaceutical care in diverse clinical settings. Collaborate with healthcare teams to enhance patient outcomes through medication management, education, and...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$77K - $202K *

Innovate healthcare payer platforms by analyzing complex issues, guiding teams, and enhancing client experiences. Collaborate on modernization efforts, leveraging Epic software to streamline operation...

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$100K - $162K *

Join us to develop and implement strategic sales plans, build customer relationships, and achieve sales goals while adhering to ethical practices. Make a positive impact in the pharmaceutical industry...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$207K - $290K *

Elevate your career by leading a dynamic Applied AI team, transforming innovative AI solutions into production-ready systems within a regulated financial environment, while collaborating across depart...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by designing and building robust data pipelines for healthcare transactions. Collaborate with partners to ensure seamless integration and reliability of data systems, enhancing operat...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$73K - $115K *

Unlock the potential of clinical documentation integrity by driving ICD-10-CM coding accuracy and enhancing provider education. Collaborate with cross-functional teams to support risk adjustment initi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $181K *

Shape the future of nursing education by leading curriculum development, faculty empowerment, and student success initiatives. Drive compliance and foster collaboration to enhance academic operations...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$82K - $85K *

Join a team that's dedicated to fostering student success through innovative teaching and clinical coordination. This dual role combines faculty responsibilities with hands-on clinical oversight, ensu...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$155K - $190K *

Manage the planning and execution of CMC operations across multiple development programs, ensuring alignment with regulatory milestones and efficient collaboration with cross-functional teams and CDMO...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate client success by managing complex projects, ensuring timely delivery, and maintaining budget integrity. Collaborate with diverse teams to drive engagement and optimize project outcomes from i...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$201K *

Optimize your leadership skills in a dynamic role, guiding a skilled team of product managers and designers. Drive impactful product strategies that shape the future of justice and promote sustainable...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $192K *

Elevate commercial performance by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring complian...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K *

Lead nursing operations in an acute care setting, ensuring high-quality patient care and compliance with standards. Oversee staff development, manage departmental budgets, and collaborate with healthc...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$160K - $192K *

Accelerate progress at the forefront of healthcare by driving commercial performance, building relationships with providers, and ensuring patient access to innovative therapies across a defined territ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Advance your career by delivering critical cost estimates for federal programs. Collaborate with a dynamic team to enhance national security through effective budgeting and analysis of advanced commun...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.