Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$110K - $130K *

Lead the charge in clinical study start-up operations, driving team development and ensuring timely site activation. Collaborate cross-functionally to enhance processes, meet regulatory standards, and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $163K *

Transform patient care as an Advanced Registered Nurse Practitioner, providing essential diagnostic and therapeutic services in a dynamic, multidisciplinary environment. Collaborate with teams to enha...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $135K *

Transform compliance oversight in the DME order-to-payment lifecycle. Lead audits, analyze data, and coordinate payer audits while developing practical controls and reporting to enhance revenue integr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$138K - $201K *

Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Advance your career by providing expert monitoring for clinical trials, ensuring compliance with GCPs and SOPs. Collaborate with study teams, mentor peers, and enhance site performance through effecti...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$190K - $250K *

Analyze and evaluate therapeutic opportunities to drive innovation and business development. Collaborate with interdisciplinary teams to assess scientific and commercial viability, ensuring alignment...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $224K *

Advance patient outcomes by leveraging your expertise in CNS as a Medical Science Liaison. Collaborate with healthcare providers and stakeholders to deliver evidence-based insights and drive strategic...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a team that's dedicated to ensuring compliance and excellence in clinical trials. Collaborate with cross-functional teams and site personnel to manage monitoring activities, uphold regulatory sta...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K - $140K *

Join a team that's shaping compelling narratives across diverse marketing channels. You'll craft engaging copy for digital ads, emails, and more, collaborating closely with various departments to enha...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Accelerate your career by driving growth in healthcare sales. Leverage your expertise to build relationships with key accounts, navigate complex deals, and shape future services that impact the indust...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to enhancing client relationships and driving success. Oversee client performance, mentor staff, and ensure compliance while collaborating with various departments to deli...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Elevate patient care by driving oncology product success through strategic relationships and innovative solutions. Collaborate with key stakeholders to ensure timely access to therapies while exceedin...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$111K - $211K *

Advance your career by leading impactful research in public health and family planning. Drive data analysis and quality assurance efforts across low- and middle-income countries, collaborating with di...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$170K - $210K *

Unlock potential by fostering relationships within the oncology community, executing strategic business plans, and ensuring patient access to therapies while collaborating across functions to drive sa...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$254K - $382K *

Pioneer innovative clinical strategies as a senior medical leader, driving excellence in study execution and client engagement. Collaborate with cross-functional teams to enhance patient care and oper...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $206K *

Drive strategic risk management initiatives by leading regulatory audits, enhancing operational processes, and fostering cross-functional collaboration to minimize financial impacts and improve audit...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$108K - $114K *

Join a team that's dedicated to enhancing patient care as a Speech Language Pathologist. Collaborate with health professionals in a supportive environment, providing essential therapy services to impr...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $148K *

Play a key role in managing clinical trials, ensuring compliance and quality oversight of project deliverables while collaborating with cross-functional teams to meet timelines and budget goals...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform customer IT service requirements into innovative solutions that enhance loyalty and profitability. Lead technical resources in delivering high-quality financial industry solutions while ensu...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$165K - $185K *

Lead drug substance activities in process chemistry, driving projects from early to late phases. Collaborate with cross-functional teams to ensure successful manufacturing and regulatory submissions...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$240K - $270K *

Architect the financial backbone of a rapidly scaling AI-focused organization. Collaborate with leadership to design systems, drive compliance, and enable international expansion while leveraging AI f...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$80K - $95K *

Empower the CDL program by leading training initiatives, ensuring compliance, and optimizing fleet management. Collaborate with regional leaders to enhance operational efficiency and drive revenue gro...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $90K *

Lead the visual narrative of client brands by delivering exceptional design solutions across multiple channels. Collaborate with diverse teams to uphold high standards and participate in innovative pr...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$103K - $176K *

Transform downstream marketing for cutting-edge medical devices. Drive product launches, develop compelling content, analyze market trends, and ensure regulatory compliance across global regions while...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $115K *

Innovate testing strategies and enhance software quality through automated and manual verification. Collaborate across teams to ensure compliance and optimize processes while leveraging AWS and full-s...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.