Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$180K - $215K *

Lead regional sales initiatives, driving product launch success and team performance. Collaborate cross-functionally to execute strategies, foster customer relationships, and ensure compliance while b...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Take ownership of corporate governance and entity management, ensuring compliance and efficiency across multiple subsidiaries. Support M&A and financing activities while maintaining a clean corporate...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Shape the future of clinical trials by managing supply chain activities, ensuring timely delivery of essential materials and maintaining regulatory compliance. Collaborate with diverse teams to enhanc...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $135K *

Advance educational research by analyzing data and synthesizing findings to enhance student access to advanced courses. Collaborate with stakeholders to design studies, build dashboards, and communica...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$270K - $324K *

Champion your career by providing exceptional care in a supportive community health center. Enjoy a balanced schedule, collaborate with a dedicated team, and make a meaningful impact while receiving c...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$176K - $287K *

Contribute to companion diagnostic strategy and development, leading programs from biomarker feasibility to clinical validation. Collaborate across teams to ensure diagnostics align with therapeutic m...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Elevate healthcare interoperability by designing and supporting MEDITECH interfaces. Collaborate with teams to enhance data exchange, improve patient care, and ensure seamless integration across syste...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $128K *

Shape data-driven strategies by developing and automating analytics solutions. Collaborate with cross-functional teams to enhance reporting capabilities and optimize operational performance in a dynam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Transform innovative protein design through advanced AI techniques, enhancing antibody drug discovery. Collaborate across disciplines to maximize efficiency and impact, while leading research that set...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Join a team that's dedicated to establishing a robust Quality Management System, ensuring compliance and excellence in global clinical development and commercialization. Lead quality initiatives and f...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$175K - $200K *

Drive impactful change in healthcare consulting by leveraging your expertise in clinical operations and research administration. Collaborate with executive leaders to solve complex challenges and fost...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$112K - $140K *

Transform your career by leading claims advocacy efforts, managing complex coverage issues, and providing expert guidance to brokers and clients. Collaborate with teams to ensure positive outcomes and...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $110K *

Accelerate program implementation and stakeholder engagement in pharmaceutical market access. Oversee daily operations, client relations, and staff management while ensuring adherence to budgets and p...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$109K - $136K *

Drive accurate, evidence-based clinical claims while collaborating with Marketing, Legal, and Clinical teams. Build and manage the claims framework and evidence library to support bold, compliant mark...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $113K *

Deliver impactful insights by owning our marketing tech ecosystem, maximizing HubSpot and Salesforce integration, and ensuring data integrity. Collaborate across teams to translate needs into actions...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $90K *

Advance quality assurance initiatives and optimize workflows in a remote healthcare contact center. Collaborate cross-functionally to enhance compliance, improve patient outcomes, and drive continuous...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $155K *

Explore a pivotal role in shaping client relationships and driving agency success. Lead complex projects, mentor teams, and leverage your marketing expertise to deliver impactful solutions in a dynami...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$126K - $154K *

Unlock your potential as a Senior Accountant, driving financial accuracy and compliance. Collaborate across teams to enhance systems, oversee key accounting functions, and support audits in a dynamic...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $185K *

Partner with us to lead high-impact projects in healthcare marketing, managing budgets and teams while ensuring creative excellence and strategic alignment. Drive client success through collaboration...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$68K - $105K *

Help us lead enterprise-wide incident responses and internal investigations into misconduct, ensuring compliance and effective fraud detection while collaborating across departments to uphold organiza...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Champion strategic workforce planning and AI-driven work design to enhance capability, improve productivity, and advance internal mobility across teams. Drive tools and strategies aligning workforce p...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Drive go-to-market strategy for AI-powered healthcare solutions, collaborating cross-functionally to enhance product positioning, messaging, and performance. Own marketing execution and leverage insig...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$168K - $283K *

Lead the charge in advancing early-stage clinical trials for innovative Orexin-targeted therapies. Collaborate cross-functionally to shape scientific strategy, drive execution, and ensure high-quality...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$153K - $268K *

Transform clinical science in late-stage trials for innovative sleep/wake therapies. Collaborate cross-functionally to ensure compliance, drive recruitment, and deliver high-quality results while shap...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.