Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$120K - $140K *

Empower provider accounts post-launch by driving growth through strategic engagement, tailored training, and effective collaboration with internal teams. Cultivate relationships across diverse healthc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $140K *

Transform patient care by leading a team of Field Clinical Specialists, ensuring high-quality clinical education and support. Drive clinical outcomes through effective management, collaboration, and c...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$207K - $346K *

Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Optimize patient care by leading the rehabilitation department, ensuring compliance and financial performance while fostering teamwork and excellence in service delivery across multiple sites...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$190K - $225K *

Transform relationships with key opinion leaders in rare neurological diseases, providing strategic insights and guidance to inform brand strategies and enhance engagement across medical and commercia...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $155K *

Join a team that's dedicated to enhancing national security through expert program analysis. Leverage your extensive experience to support critical FAA initiatives, ensuring compliance and effective p...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$256K - $347K *

Lead the charge in ensuring optimal safety standards for Rare Disease products. Establish pharmacovigilance strategies, oversee safety profiles, and engage cross-functional teams to deliver critical t...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$242K - $403K *

Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Drive regulatory intelligence initiatives to ensure compliance and support clinical research. Collaborate with experts to assess regulatory changes, track global guidelines, and enhance impact assessm...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $126K *

Drive innovative solutions by blending product analytics and low-code development, collaborating cross-functionally to enhance AI Agent capabilities and optimize Revenue Cycle operations within the he...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $150K *

Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$245K - $286K *

Elevate clinical quality assurance through strategic leadership and oversight of global trials, ensuring compliance with GCP regulations. Drive quality culture and inspection readiness while mentoring...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$122K *

Champion clinical excellence by leading large teams, ensuring strategic alignment, and driving patient recruitment while mitigating risks in clinical operations for successful study execution...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Transform global client relationships by driving revenue growth and strategic account management. Collaborate with C-suite executives to connect workplace culture and employee experience to measurable...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$149K - $224K *

Drive analytics excellence by leading a team to deliver impactful insights, enhance reporting capabilities, and support strategic decision-making across diverse business functions. Foster collaboratio...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$165K - $264K *

Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $180K *

Advance healthcare by driving product adoption and education in colorectal cancer screening across a key geographic territory. Collaborate with healthcare providers to enhance market penetration and e...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$189K - $256K *

Join a global team to shape regulatory strategies in biotechnology, supporting product development and lifecycle management in Inflammation and Rare Diseases. Lead regulatory efforts, ensure complianc...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Shape the future of executive recruitment by leading strategic sourcing, engaging high-level candidates, and collaborating with a dedicated team to uncover top talent. This role offers growth opportun...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Inspire patient recruitment strategies by leading a dynamic team, collaborating with senior management, and leveraging innovative tools to enhance enrollment across clinical trials while ensuring dive...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Elevate senior care by delivering high-quality, relationship-based primary care. Enjoy autonomy and flexibility while collaborating with a dedicated team to improve patient outcomes and enhance the li...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $250K *

Unlock potential by leading innovative clinical documentation initiatives that enhance quality, compliance, and revenue cycle outcomes. Collaborate with cross-functional teams to redefine workflows an...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.