Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$146K - $182K *

Join a team that's advancing cancer detection through innovative machine learning models. Drive algorithm development and collaborate across disciplines to enhance tissue-free assays, ensuring high-qu...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $135K *

Join a team that's shaping the future of data management by guiding strategic direction and execution for B2G registration and reporting platforms. Collaborate across technical and business domains to...

Iowa City, IARemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $135K *

Lead the charge in shaping data management strategies and solutions for B2G registration and reporting platforms. Collaborate across teams to enhance automated tools and ensure compliance, driving inn...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$180K - $240K *

Transform the future of distributed systems by designing and building robust platform components. Collaborate with teams to ensure reliability and scalability in mission-critical environments, driving...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$102K - $136K *

Join a team that's transforming healthcare by developing essential tooling and AI capabilities for engineers. This role spans software development, architecture, and collaboration in an Agile environm...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$228K - $285K *

Pioneer advancements in AI inference platforms, driving strategy and execution across cross-functional teams to enhance scalability and reliability for enterprise customers. Lead product initiatives f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Champion the recruitment process by sourcing top technical talent, collaborating with leadership, and executing full-cycle hiring strategies to meet business objectives in a fast-paced startup environ...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $105K *

Engage in comprehensive finance integration for acquired companies, ensuring accurate data mapping, system conversion, and post-close stabilization. Collaborate with cross-functional teams to streamli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$199K - $235K *

Innovate backend solutions by designing, building, and maintaining scalable services for external pentesting. Collaborate across teams to enhance user experience and ensure system performance, reliabi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$104K - $166K *

Unlock your potential as you build and enhance a cutting-edge data platform, driving innovation in federal background investigations. Collaborate in a high-trust, remote environment while ensuring dat...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $199K *

Develop and maintain scalable data pipelines, leveraging Snowflake and cloud tools to enhance data quality and accessibility. Mentor a growing team while driving best practices in data engineering and...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$127K - $171K *

Champion high-impact deployments by leveraging data intelligence and AI to drive governance solutions in regulated industries, serving as a trusted advisor to stakeholders and delivering measurable va...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$132K - $165K *

Drive innovation in oncology diagnostics by leading statistical programming efforts, ensuring data integrity and compliance for clinical trials, while managing a team and collaborating cross-functiona...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock potential by designing and implementing a cloud-native architecture. Assess legacy infrastructure, create detailed design documents, and collaborate with engineering to modernize critical data...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$108K - $140K *

Transform talent acquisition by leading a dynamic recruiting team, driving data-informed strategies, and enhancing candidate experiences to meet organizational growth and workforce needs...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$118K - $180K *

Join a dynamic team to analyze solar PV energy yield assessments for utility-scale projects. Lead performance modeling and mentor engineers while expanding expertise across various renewable energy te...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $120K *

Accelerate growth by driving AI adoption in legal teams. You'll convert inbound leads and build outbound strategies to tap into a vast market, managing demos, trials, and closing deals while collabora...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$180K - $225K *

Transform the claims process by building robust event-driven systems. As a key player, you'll design, implement, and maintain backend services, ensuring reliability and efficiency while mentoring fell...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$72K - $115K *

Partner with us to design and validate predictive models that enhance business processes across various domains, leveraging data science techniques to drive insights and improve decision-making within...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $130K *

Drive the design and deployment of secure AI applications in cloud environments, integrating advanced technologies like machine learning and ServiceNow solutions to enhance operational efficiency and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Elevate data privacy standards by leading a comprehensive privacy program. Collaborate across teams to integrate privacy-by-design principles, enhance data governance, and ensure compliance while enab...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Join our new Data Engineering team to lead business intelligence initiatives, build trusted data models in Snowflake, and deliver impactful reports in Power BI. Collaborate with stakeholders to enhanc...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$90K - $120K *

Develop and implement reliability engineering strategies to enhance asset management and operational efficiency. Collaborate with cross-functional teams to optimize maintenance programs and ensure com...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Unlock potential by joining a dynamic team of Solution Consultants, delivering expert guidance on Atlassian products to help clients maximize their investments and achieve strategic outcomes in the Pu...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$210K - $256K *

Transform industry practices by leading large-scale AI and data initiatives, driving business growth and operational excellence within Consumer Products, Retail, and Logistics sectors...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.