Pfizer

Sr. Director, Cyber Defense

Pfizer$254K — $423K *
Information Technology
11 - 15 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree in Cybersecurity, Computer Science, Information Systems, or related field; 12-15+ years of cybersecurity experience, including 8 years in leadership roles.
  • Proven expertise in cybersecurity domains: vulnerability management, threat intelligence, SOC operations, incident response, insider risk, network and cloud security.
  • Strong understanding of security architecture and technologies: firewalls, IDS/IPS, WAF, DDoS mitigation, SIEM, SOAR, and cloud-native tools.
  • Extensive knowledge of Crowdstrike suite capabilities for SIEM, EDR and threat intelligence.
  • Professional certifications like CISSP, GIAC (GCIA, GCIH), CISM or equivalent required.
  • Ability to communicate technical risk in business terms to executive stakeholders.
  • Familiarity with threat modeling frameworks and adversary simulation methodologies such as MITRE ATT&CK.

Responsibilities

  • Define and execute strategy for Cyber Security Posture Management, Network Security, Cloud Security, and Cyber Defense aligned with business priorities.
  • Manage budgets, ensuring effective resource allocation and identifying cost optimization opportunities.
  • Advise the CISO and senior leadership on threat trends and operational readiness.
  • Transform legacy cybersecurity systems and implement modern security practices.
  • Oversee the global cyber defense program, ensuring proactive threat detection and incident response.
  • Direct the cloud security program, enforcing controls across identity, access management, and compliance.
  • Lead vulnerability management initiatives, including scanning, prioritization, and remediation.

Benefits

  • Comprehensive health benefits including medical, prescription drug, dental, and vision coverage.
  • 401(k) plan with Pfizer Matching Contributions and Retirement Savings Contributions.
  • Paid vacation, holiday, personal days, caregiver/parental and medical leave.
  • Supportive programs for colleagues to lead healthy lives and balance life’s moments.
Full Job Description
ROLE SUMMARY

Our Cyber Defense team is the frontline of Pfizer's cybersecurity operations, responsible for detecting, investigating, and responding to threats that could impact the confidentiality, integrity, and availability of our systems and data. This team leads critical functions including Security Operations Center (SOC) monitoring, incident response, digital forensics, penetration testing, threat intelligence, host security, platform support, and security automation.

This leader will oversee enterprise-wide efforts in vulnerability management, threat intelligence, red teaming, SOC operations, incident response, insider risk, and secure network and cloud architecture. The ideal candidate will bring deep expertise in cyber operations, threat management, and security architecture, with a proven track record of driving large-scale, cross-functional cybersecurity programs. This role requires strong leadership, operational rigor, and the ability to translate technical risk into business-aligned strategies.

ROLE RESPONSIBILITIES
  • Define and execute a comprehensive strategy for the Cyber Security Posture Management, Network Security, Cloud Security, and Cyber Defense programs aligned with Pfizer's cybersecurity vision and business priorities.
  • Develop and manage budgets, ensuring alignment with organizational goals and effective allocation of resources. Monitor expenditures, forecast future budget needs and identify opportunities for cost optimization.
  • Serve as a key advisor to the CISO and senior leadership on threat trends, operational readiness, and incident response posture.
  • Lead the transformation of legacy cybersecurity systems and drive the implementation of modern security practices across the organization.
  • Oversee the global cyber defense program, inclusive of the 24x7 SOC, ensuring proactive threat detection, effective monitoring, alert triage, and coordinated incident response.
  • Direct the strategy and execution of Pfizer's cloud security program, ensuring robust controls across identity and access management, encryption, monitoring, and compliance,
  • Lead a proactive vulnerability management program, including scanning, prioritization, remediation, and executive reporting.
  • Partner with IT and business units to ensure timely resolution of critical vulnerabilities and alignment with enterprise risk tolerance.
  • Drive the strategy and implementation of network security controls, including segmentation, firewalls, intrusion detection/prevention, and secure remote access.
  • Ensure continuous monitoring and protection of Pfizer's global network infrastructure against emerging threats.
  • Lead and mentor high-performing teams across Cyber Posture Management, Network Security, Cloud Security, and Cyber Defense.


BASIC QUALIFICATIONS
  • Bachelor's degree in Cybersecurity, Computer Science, Information Systems, or related field with 12 -15+ years of experience in cybersecurity, with at least 8 years in leadership roles overseeing enterprise-wide cyber operations.
  • Proven expertise in multiple cybersecurity domains, including vulnerability management, threat intelligence, SOC operations, incident response, insider risk network security, and cloud security.
  • Strong understanding of security architecture and technologies such as firewalls, IDS/IPS, WAF, DDoS mitigation, SIEM, SOAR, and cloud-native security tools.
  • Extensive understanding of the Crowdstrike suite, including its capabilities for SIEM, EDR and threat intelligence
  • Professional certifications such as CISSP, GIAC (e.g., GCIA, GCIH), CISM, or equivalent.
  • Demonstrated ability to translate technical risk into business-aligned strategies and communicate effectively with executive stakeholders.
  • Deep familiarity with threat modeling frameworks and adversary simulation methodologies (e.g., MITRE ATT&CK, red/purple teaming).


PREFERRED QUALIFICATIONS
  • Experience with Wiz for cloud security management, including configuration, monitoring, and reporting.
  • Experience with Zscaler for secure network access, including implementation, configuration, and performance optimization.
  • Experience leading modernization initiatives and transforming legacy cybersecurity systems.
  • Demonstrated experience negotiating multi-million dollar contracts with vendors and strategic partners.
  • Experience working abroad and leading global cybersecurity initiatives across multiple regions.


NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
  • Periodic international and domestic travel may be required (less than 5%).
  • Work Location Assignment: Must be able to work in the assigned office 2-3 days per week, or as needed by the business.
  • This role is NOT remote.


Last Date to Apply for Job: 7/27/2026

Additional Posting Location: Collegeville, PA

The annual base salary for this position ranges from $254,100.00 to $423,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 25.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.
Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

About Pfizer

Hospira, Inc. is the provider of injectable drugs and infusion technologies. Through its broad, integrated portfolio, Hospira is uniquely positioned to Advance Wellness™ by improving patient and caregiver safety while reducing healthcare costs. The company is headquartered in Lake Forest, Ill., and has approximately 16,000 employees.

Pfizer Careers

Joining Pfizer’s global team offers more than just job opportunities; it’s a chance to be a part of a company that leads with science and innovates for better health. As a leading biopharmaceutical company, Pfizer is at the forefront of transforming lives through innovation, leadership, and diversity. Work You’ll Do At Pfizer, you will collaborate with some of the brightest minds in the industry, engaging in work that enhances global health and saves lives. Our culture thrives on intellectual curiosity, professional growth, and inclusivity, making every day a learning opportunity. Here, your skills will be honed, your professional acumen will be expanded, and you will be part of a team that values the power of diverse insights to drive success. Pfizer’s Leadership and Growth Lead and innovate with Pfizer, where we value the growth of each employee. Our leadership is committed to providing employees with the training and resources needed to excel in their careers. Pfizer offers a variety of career paths, including roles in research, marketing, finance, technology, and more, each offering a unique blend of challenges and rewards. Internship and Employment Opportunities Start your career with Pfizer through our internship programs or dive straight into a full-time position. We are hiring individuals who are passionate about healthcare and who seek to make a difference in the world. Our internships provide invaluable industry experience, networking opportunities, and a potential pathway to full-time employment. Benefits and Culture Pfizer is dedicated to fostering a workplace where all employees feel valued and can achieve their full potential. We offer competitive benefits packages that support the health, well-being, and financial security of our employees and their families. At Pfizer, you’ll find a culture that encourages collaboration, innovation, and continuous learning. Join Our Team Explore the numerous job opportunities at Pfizer by searching open positions that match your skills and interests. We look for driven, curious, and innovative team players who are ready to advance their careers in a transformative company. Stay Connected Keep up to date with career tips, insider perspectives, and industry-leading insights you can put to use today—all from the people who work here. Personalize your subscription to receive job alerts, latest news, and insider tips tailored to your preferences. Discover the exciting and rewarding career opportunities that await at Pfizer. Interview and Resume Tips Prepare for your future with Pfizer by utilizing our resources for resume building and interview preparation. We provide guidance on how to effectively showcase your skills and experiences to align with the needs of a position at Pfizer. Our goal is to help you succeed in securing a role that suits your professional goals and personal growth aspirations. Pfizer: A Place Where You Can Make a Difference Every position at Pfizer contributes to our mission of making the world a healthier place. Whether through direct patient care, research innovation, or corporate roles that support our operations, your work will have global impact. Join us in our journey to change lives—explore Pfizer careers today.
Learn more about Pfizer
Size
79,000 employees
Market Cap
$285.9 billion
Industry
Net Income
$9.6 billion
Founded
1849
5 Year Trend
+9%
Revenue
$41.9 billion
NASDAQ

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