Why Join Us?

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides - Helicons™ - capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered "undruggable" despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What's the opportunity?

Parabilis Medicines is seeking a Senior Director, Clinical Sciences to provide scientific and strategic leadership across our clinical development programs. This role is central to translating discovery and preclinical innovation into high-quality, data-driven clinical development strategies that advance our pipeline efficiently and responsibly.

As Senior Director, Clinical Sciences, you will shape clinical science strategy from early clinical planning through execution, ensuring scientific rigor, regulatory alignment, and cross-functional integration. You will be a key scientific voice in clinical trial design, interpretation of clinical data, and external engagement, with a direct impact on the success of Parabilis' clinical programs and long-term company goals.

As part of this role you will:

• Lead and own clinical science strategy for one or more clinical programs across development stages
• Drive scientific input into protocol design, endpoint selection, and clinical development plans
• Serve as a core contributor to regulatory interactions, governance decisions, and program reviews
• Influence portfolio strategy through integrated clinical and translational insights
• Partner closely with Clinical Operations to ensure scientifically sound and feasible trial execution
• Interpret and contextualize clinical, biomarker, and safety data to inform decision-making
• Contribute to regulatory documents (INDs, IBs, briefing packages) and regulatory interactions
• Support investigator meetings, advisory boards, and external scientific communications
• Ensure consistency of scientific messaging across internal and external stakeholders
• Mentor and guide junior clinical scientists as the organization grows
• Leverage AI-enabled tools to enhance clinical insights, literature analysis, data interpretation, and operational efficiency

What you'll need to be successful:

• PhD, PharmD, or equivalent advanced degree in life sciences, medicine, or a related field
• 10+ years of experience in clinical development or clinical sciences within biotech or pharmaceutical settings
• Direct experience supporting or leading clinical trials (Phase 1-3 preferred)
• Proven track record of contributing to successful clinical programs and regulatory milestones
• Deep understanding of clinical trial design, endpoints, and regulatory requirements
• Experience working with clinical data systems, trial databases, and scientific literature platforms
• Familiarity with biomarker and translational data integration
• Strong scientific writing and data presentation skills
• Experience in rare disease, oncology, immunology, or other complex therapeutic areas (as applicable to Parabilis' pipeline)
• Prior leadership or matrix-management experience
• Experience interacting with regulatory agencies and external experts
• Strong strategic thinking combined with hands-on execution
• Comfort operating in a fast-paced, evolving biotech environment
• Demonstrated use of AI tools in your current role and responsibilities is required. Advanced or innovated use of AI is a strong plus.

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We're inventing a new class of medicines-one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We're All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is [$265,000-$305,000 per year], depending on experience, qualifications, and internal practices. Parabilis's total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitivebenefits designed to support our employees' overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com