Job Summary:
Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company.
We are looking for a highly motivated and innovative candidate for the role of Scientist / Senior Scientist of Analytical Development. The expectation is that the Scientist / Senior Scientist will have experience independently executing analytical experiments using HPLC/UPLC techniques. Reporting to the Associate Director of Analytical Development, the right candidate will be a strategic thinker that brings a leadership presence and enthusiasm for Strand along with a desire to conquer new challenges.
Primary Responsibilities:
- Leads development, execution, and validation of RP-IP/RP/IEX based analytical methods to establish identity, purity, potency, and stability criteria for early-stage mRNA and LNP formulations using UPLC-ESI-ToF, PDA, and CAD.
- Analyzes data and draws conclusions which drive screening, optimization, and scale-up efforts in mRNA and LNP Process Development.
- Serves as subject matter expert in analytical chemistry, mass spectrometry, and method qualification and transfer.
- Interfaces with external contract research organizations to ensure compliance with internal timeline and quality requirements.
- Mentors and develops junior scientists in analytical theory and in applications of analytical technology and software platforms.
- Created proprietary ToF mass spec oligonucleotide mass target and predictive sequence library software to rapidly profile known and identify unknown oligonucleotide mass signals.
- Maintains electronic notebook records and authors protocols.
- Contributes to data packages for regulatory submissions.
- Actively maintains current understanding of RNA and LNP landscape by attending conferences and other events.
Qualifications:
- B.S. or Advanced Degree in Chemistry, Chemical Engineering, Biology, Biochemistry, Molecular Biology or other relevant scientific discipline.
- 7+ years of experience with a focus on varying liquid chromatography modes (RP, RP-IP, AEX, SEC, etc), LC-MS, or capillary gel electrophoresis.
- Working experience in HPLC/UPLC method development.
- Experience with enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for biologics or nucleic acid therapies.
- This position requires conducting laboratory experiments, excellent documentation review and writing skills, and the flexibility to work on multiple projects as needed.
- Understanding of process development, and/or regulatory aspects of mRNA-(lipid) nanoparticle products would be a plus.
- Ability to quickly adapt to change and thrive in a dynamic and entrepreneurial early-stage environment.
- A strong team player with excellent oral and written communication skills and a demonstrated ability to work independently.
- Independently motivated, detail oriented and good problem-solving ability.
Strand offers a fast-paced, entrepreneurial, team-focused small company environment. We also offer a top-notch benefits package (health, dental, life, open PTO, onsite lunch catering, commuter support and more) and work/life flexibility and integration. Being part of the Strand team allows you to become part of a small team that supports professional development while working together to meet Strand's goals.
Job Type: Full-time
Salary: $120,000 - $142,000 annually plus bonus and equity incentives
Pay Transparency Base Salary Range
$120,000-$142,000 USD
