Career CategoryManufacturing
Job DescriptionContract Development & Manufacturing Senior ManagerWhat you will doLet's do this. Let's change the world. In this vital role, you will provide strategic and operational leadership within Amgen Contract Development and Manufacturing (ACDM), driving execution of external development and manufacturing activities for Synthetic Drug Substance (DS) programs supporting Antibody Drug Conjugate (ADC) and Small Molecule modalities across clinical and commercial stages.
This role is responsible for leading complex, cross-functional programs with external development and manufacturing partners (CDMOs/CROs) to ensure reliable, compliant, and efficient supply execution. The successful candidate will demonstrate strong leadership capabilities, technical breadth across synthetic modalities, and the ability to influence internal and external stakeholders in a dynamic global environment. This position sits within External Supply in Operations and plays a critical role in enabling Amgen's external sourcing and manufacturing strategy across the portfolio. In alignment with evolving business needs, this role may also support additional hybrid or emerging modalities.
Key Responsibilities- Lead external Synthetic DS programs for ADC and Small Molecule modalities across development, clinical, and commercial stages.
- Serve as the primary interface with CDMOs/CROs and internal cross-functional teams including Process Development, Quality, Supply Chain, Analytical, Regulatory, and Strategic Sourcing.
- Drive sourcing activities including supplier selection, onboarding, scope of work development, and proposal management.
- Oversee manufacturing operations, technical transfers, compliance, and issue resolution with external partners.
- Ensure project delivery against quality, compliance, supply, timeline, and cost objectives.
- Lead risk management, escalation resolution, and operational decision-making across programs.
- Build strong internal and external partnerships to support program success and operational excellence.
- Influence and lead matrix teams in a fast-paced, complex environment.
- Manage quality systems activities including deviations, investigations, change controls, and CAPAs.
- Manage budgets, purchase orders, and financial forecasting for external manufacturing activities.
- Drive continuous improvement, process optimization, and operational excellence initiatives.
- Support supplier management and contract-related activities.
- Mentor and train ACDM staff and cross-functional teams and demonstrate strong leadership, collaboration, and accountability.
- Support additional hybrid or emerging modalities based on business needs.
- Travel up to 20%, including domestic and international travel.
What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The dedicated professional we seek is a collaborative partner with these qualifications.
Basic Qualifications:- Doctorate degree and 2 years of Manufacturing, Operations, Process Development, or External Supply experience OR
- Master's degree and 4 years of Manufacturing, Operations, Process Development, or External Supply experience OR
- Bachelor's degree and 6 years of Manufacturing, Operations, Process Development, or External Supply experience OR
- Associate's degree and 10 years of Manufacturing, Operations, Process Development, or External Supply experience OR
- High school diploma / GED and 12 years of Manufacturing, Operations, Process Development, or External Supply experience
Preferred Qualifications:- Advanced degree in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or related field preferred.
- 10+ years of pharmaceutical or biotechnology experience in Synthetic DS development and manufacturing.
- Experience supporting Small Molecule and/or ADC modalities from development through commercial manufacturing.
- Proven leadership of external manufacturing programs with CDMOs/CROs in a cGMP environment.
- Strong knowledge of cGMPs, quality systems, regulatory/CMC requirements, and pharmaceutical operations.
- Experience with sourcing strategies, supplier management, and commercial supply operations.
- Strong project management, strategic thinking, and problem-solving skills.
- Experience managing deviations, investigations, change controls, and CAPAs with external partners.
- Demonstrated ability to lead and influence cross-functional, matrixed teams.
- Strong communication, collaboration, negotiation, and stakeholder management skills.
- Self-starter who thrives in fast-paced, complex environments and drives continuous improvement.
- Demonstrated commitment to teamwork, accountability, innovation, and patient focus.
What you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.
careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Sponsorship
Sponsorship for this role is not guaranteed.
