Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director of Engineering, Webapp & AI Attack
$290K - $340K *
Lead and inspire engineering teams to develop cutting-edge web and AI security solutions. Drive strategy, execution, and organizational health while fostering a culture of innovation and accountabilit...
1 week ago
Software Engineering Manager (R37)
$101K - $206K *
Join a team that's redefining AI product development by leading high-performing engineering teams. Drive innovation and collaboration across functions to deliver scalable AI solutions, while fostering...
3 weeks ago
Senior Backend Engineer - Microservices
$131K - $178K *
Develop and support scalable microservices for enterprise systems, collaborating with product and engineering teams to ensure high-quality delivery within a cloud-native platform, while mentoring and...
Reposted 3 days ago
Senior Manager, Global Deal Desk
$125K - $150K *
Champion scalable deal operations by leading the Global Deal Desk, optimizing complex agreements across sales, finance, and legal. Drive AI integration to enhance workflows and ensure compliance while...
2 weeks ago
Workday Business Solutions Analyst
$88K - $138K *
Drive cross-functional projects by translating business needs into technical requirements, ensuring successful adoption of solutions across various People Technology platforms, including Workday and T...
Reposted today
Geotechnical Section Leader - Kansas City, MO
$110K - $130K *
Elevate the field of geotechnical engineering by leading innovative design and risk management strategies for transportation and infrastructure projects. Foster collaboration across disciplines to enh...
Reposted 3 weeks ago
$110K - $130K *
Elevate customer success by leading a dynamic team focused on driving adoption, enhancing relationships, and achieving measurable outcomes through collaboration and strategic initiatives across variou...
2 weeks ago
Sr. Application Security Engineer
$140K - $160K *
Join a team that's redefining application security by partnering with engineering leaders to influence secure design, conduct hands-on code reviews, and enhance security tooling, all while navigating...
4 days ago
$121K - $169K *
Shape the future of travel technology by leading complex technical projects. Collaborate across teams to define goals, manage risks, and ensure successful delivery while adapting practices to meet pro...
1 week ago
$110K - $130K *
Elevate your career by implementing and supporting AWS cloud solutions in a dynamic environment. Collaborate with experts to optimize performance and ensure secure, scalable infrastructure for federal...
1 week ago
Principal Group Product Manager- AL Labs
$170K - $243K *
Transform product innovation by leading AI-driven strategies and experiments, collaborating across teams to enhance software solutions and improve employee experiences in a dynamic, fast-paced environ...
2 weeks ago
$185K - $260K *
Champion security excellence by designing and implementing robust software solutions. Collaborate with teams to enhance security practices, conduct code reviews, and respond to incidents, ensuring a s...
2 weeks ago
$135K - $160K *
Lead the development and operation of a cutting-edge Security Observability & Data Platform, enhancing endpoint security, threat detection, and incident response while driving innovation in security s...
Reposted today
Sr. Principal Technical Program Manager, End-to-End Data Center Delivery
$126K - $264K *
Lead the charge in delivering hyperscale data center capacity through strategic oversight, ensuring projects meet quality standards and timelines while managing complex technical and commercial challe...
1 week ago
Senior Manager, Engineering Recruiting
$110K - $130K *
Lead the charge in engineering recruiting by shaping hiring strategies, developing a high-performing team, and enhancing scalable processes to support growth while personally managing senior leadershi...
2 weeks ago
Director/Client Partner - Enterprise AI
$180K - $220K *
Transform enterprise AI partnerships by leading strategic growth initiatives, enhancing relationships, and driving revenue across key Google organizations. Leverage your expertise in AI, cloud, and di...
Reposted today
Senior Cyber Security Engineer
$110K - $130K *
Transform cybersecurity practices by leading vulnerability management and penetration testing efforts. Collaborate with cross-functional teams to enhance security controls, reduce risks, and ensure ro...
6 days ago
$120K - $151K *
Shape the product roadmap and drive delivery from discovery to launch, collaborating with cross-functional teams to ensure customer-centric solutions and measurable business outcomes in a dynamic B2B...
4 days ago
Full Stack Forward Deployed Engineering Manager
$94K - $316K *
Elevate enterprise capabilities by designing and deploying agentic AI systems. Collaborate with clients to innovate workflows, integrate platforms, and ensure scalability across complex environments w...
Reposted 2 days ago
Full Stack Forward Deployed Engineering Manager
$94K - $316K *
Transform enterprise environments by designing and deploying innovative AI-driven solutions. Collaborate with clients to define requirements, engineer custom agentic workflows, and optimize cloud-nati...
Reposted 4 days ago
Engineering Manager, Fan Experience
$230K - $271K *
Join a dynamic team as an Engineering Manager, leading full-stack and front-end engineers to enhance fan experiences. Collaborate closely with Product and Design, driving innovation and quality in a f...
Today
Business Development Manager - Embedded Software Services
$115K - $207K *
Champion new business development by driving customer acquisition for embedded software services. Lead the sales lifecycle, build strategic relationships, and ensure successful project delivery while...
Today
Application Integration Engineer 1
$89K - $107K *
Drive innovation in application integration by designing and supporting secure data flows across enterprise systems. Collaborate with teams to enhance performance and ensure data integrity while lever...
Yesterday
Senior Product Designer - Fresh Sous Vide
$80K - $95K *
Elevate the future of fresh food by designing innovative sous vide protein products. Collaborate with cross-functional teams to create exceptional culinary experiences that enhance nutrition, convenie...
2 weeks ago
Staff Engineer, Manufacturing Engineering
$108K - $130K *
Elevate manufacturing excellence by providing technical leadership in complex processes, enhancing production efficiency, and implementing advanced technologies while collaborating across functions to...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.