Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$290K - $340K *

Lead and inspire engineering teams to develop cutting-edge web and AI security solutions. Drive strategy, execution, and organizational health while fostering a culture of innovation and accountabilit...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$101K - $206K *

Join a team that's redefining AI product development by leading high-performing engineering teams. Drive innovation and collaboration across functions to deliver scalable AI solutions, while fostering...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$131K - $178K *

Develop and support scalable microservices for enterprise systems, collaborating with product and engineering teams to ensure high-quality delivery within a cloud-native platform, while mentoring and...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Champion scalable deal operations by leading the Global Deal Desk, optimizing complex agreements across sales, finance, and legal. Drive AI integration to enhance workflows and ensure compliance while...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $138K *

Drive cross-functional projects by translating business needs into technical requirements, ensuring successful adoption of solutions across various People Technology platforms, including Workday and T...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Elevate the field of geotechnical engineering by leading innovative design and risk management strategies for transportation and infrastructure projects. Foster collaboration across disciplines to enh...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Elevate customer success by leading a dynamic team focused on driving adoption, enhancing relationships, and achieving measurable outcomes through collaboration and strategic initiatives across variou...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $160K *

Join a team that's redefining application security by partnering with engineering leaders to influence secure design, conduct hands-on code reviews, and enhance security tooling, all while navigating...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$121K - $169K *

Shape the future of travel technology by leading complex technical projects. Collaborate across teams to define goals, manage risks, and ensure successful delivery while adapting practices to meet pro...

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$110K - $130K *

Elevate your career by implementing and supporting AWS cloud solutions in a dynamic environment. Collaborate with experts to optimize performance and ensure secure, scalable infrastructure for federal...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$170K - $243K *

Transform product innovation by leading AI-driven strategies and experiments, collaborating across teams to enhance software solutions and improve employee experiences in a dynamic, fast-paced environ...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$185K - $260K *

Champion security excellence by designing and implementing robust software solutions. Collaborate with teams to enhance security practices, conduct code reviews, and respond to incidents, ensuring a s...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Lead the development and operation of a cutting-edge Security Observability & Data Platform, enhancing endpoint security, threat detection, and incident response while driving innovation in security s...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$126K - $264K *

Lead the charge in delivering hyperscale data center capacity through strategic oversight, ensuring projects meet quality standards and timelines while managing complex technical and commercial challe...

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the charge in engineering recruiting by shaping hiring strategies, developing a high-performing team, and enhancing scalable processes to support growth while personally managing senior leadershi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Transform enterprise AI partnerships by leading strategic growth initiatives, enhancing relationships, and driving revenue across key Google organizations. Leverage your expertise in AI, cloud, and di...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Transform cybersecurity practices by leading vulnerability management and penetration testing efforts. Collaborate with cross-functional teams to enhance security controls, reduce risks, and ensure ro...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $151K *

Shape the product roadmap and drive delivery from discovery to launch, collaborating with cross-functional teams to ensure customer-centric solutions and measurable business outcomes in a dynamic B2B...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$94K - $316K *

Elevate enterprise capabilities by designing and deploying agentic AI systems. Collaborate with clients to innovate workflows, integrate platforms, and ensure scalability across complex environments w...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Business Services

$94K - $316K *

Transform enterprise environments by designing and deploying innovative AI-driven solutions. Collaborate with clients to define requirements, engineer custom agentic workflows, and optimize cloud-nati...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Business Services

$230K - $271K *

Join a dynamic team as an Engineering Manager, leading full-stack and front-end engineers to enhance fan experiences. Collaborate closely with Product and Design, driving innovation and quality in a f...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Consumer Technology

$115K - $207K *

Champion new business development by driving customer acquisition for embedded software services. Lead the sales lifecycle, build strategic relationships, and ensure successful project delivery while...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Consumer Technology

$89K - $107K *

Drive innovation in application integration by designing and supporting secure data flows across enterprise systems. Collaborate with teams to enhance performance and ensure data integrity while lever...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Elevate the future of fresh food by designing innovative sous vide protein products. Collaborate with cross-functional teams to create exceptional culinary experiences that enhance nutrition, convenie...

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$108K - $130K *

Elevate manufacturing excellence by providing technical leadership in complex processes, enhancing production efficiency, and implementing advanced technologies while collaborating across functions to...

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.