Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$116K - $149K *

Reimagine product marketing for partnerships by crafting compelling narratives and executing go-to-market strategies. Collaborate cross-functionally to enhance customer experiences and drive successfu...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $240K *

Join us to build and operate secure infrastructure for federal and partner environments. This hands-on role focuses on Kubernetes, infrastructure as code, and production support, ensuring reliable dep...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$108K - $157K *

Optimize data-driven strategies by transforming raw analytics into actionable insights. Collaborate with cross-functional teams to enhance marketplace dynamics and drive measurable business outcomes i...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Champion innovative software solutions in supply chain logistics. Collaborate with teams to enhance web applications, ensuring quality and efficiency in reverse logistics processes. Drive customer sat...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$122K - $171K *

Unlock potential by driving data-driven insights for Customer Success. Collaborate across teams to enhance customer journeys, optimize growth strategies, and shape analytics foundations that support A...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$172K - $215K *

Join a team that's transforming public safety through innovative drone solutions. Lead complex deployments, drive technical wins, and shape the future of sUAS operations while mentoring a talented eng...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$150K - $180K *

Join us to architect a unified web platform that enhances user experience across multiple services. Lead front-end development, optimize performance, and mentor engineers while ensuring seamless integ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Transform enterprise network architecture by leading LAN migration projects, ensuring seamless transitions to Cisco SDA fabric. Collaborate with cross-functional teams to execute plans, manage changes...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$190K - $267K *

Drive impactful ad experiences by leveraging your frontend expertise in JavaScript and TypeScript. Collaborate with cross-functional teams to enhance user engagement and optimize ad performance across...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$212K - $339K *

Shape the future of AI infrastructure by architecting secure, scalable platforms for LLM training and production. Collaborate with cross-functional teams to solve complex challenges and drive innovati...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Champion user experience by enhancing our insurance platform's web interface. Collaborate with teams to simplify design, implement UX initiatives, and develop solutions that empower agents and interna...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$165K - $260K *

Drive the development of an intelligent content delivery network, optimizing web performance through cutting-edge infrastructure and AI. Collaborate with a lean team to transform complex problems into...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$145K - $170K *

Join a dynamic eCommerce team to enhance the online booking experience. Lead complex features in a Next.js and TypeScript application, impacting conversion and patient trust across multiple countries...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $195K *

Join a team that's redefining account marketing for major clients. Collaborate with cross-functional partners to drive growth, enhance customer engagement, and create tailored marketing strategies tha...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Transform strategic initiatives by leading partnerships that drive growth and innovation. Collaborate across teams to enhance business objectives and foster relationships that unlock new opportunities...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $115K *

Transform your career by leading strategic, cross-functional projects that drive business success. Collaborate with executive leaders and stakeholders to navigate complex challenges and deliver impact...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $160K *

Transform data operations by leading our Snowflake platform migration, ensuring security, reliability, and cost efficiency while collaborating across teams to standardize practices and enhance data ma...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$174K - $209K *

Innovate within a dynamic team to design and enhance full-stack applications that drive Grafana's core business operations, ensuring seamless customer experiences and robust internal processes across...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $145K *

Join a team that's shaping the future of cloud infrastructure by leading engineering efforts for a cutting-edge Operational Decisioning Platform. Drive innovation, enhance developer experience, and en...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Empower our privacy program by automating processes, managing data subject requests, and ensuring compliance with GDPR and CCPA. You'll leverage technical skills to build scalable tools and systems, d...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $149K *

Analyze and enhance IT infrastructure through secure cloud solutions, ensuring 24x7 availability. Collaborate with teams to streamline workflows, improve system reliability, and tackle complex challen...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$150K - $175K *

Lead the charge in architecting and managing robust cloud platforms, driving modernization efforts, and automating infrastructure solutions for large-scale enterprises. Collaborate with top engineers...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K *

Innovate your career as a Principal Data Engineer, designing cutting-edge data infrastructure and lakehouse solutions. Leverage modern AI tools to enhance performance and quality while collaborating w...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$113K - $178K *

Drive your career with a senior role focused on software development for control room simulators, collaborating with engineers to enhance plant models and ensure high-quality deliverables in a dynamic...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.