Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$133K - $184K *
Join a team that's enhancing threat detection and response capabilities. As a hands-on technical leader, you'll drive security initiatives across cloud, infrastructure, and identity platforms, while m...
1 week ago
$120K - $145K *
Optimize runtime authorization strategies across diverse segments, driving technical wins and enabling Sales Engineers. Leverage deep IAM and PAM expertise to deliver impactful solutions, ensuring com...
2 weeks ago
Staff Product Manager, In Store Offerings
$220K - $240K *
Elevate your career by leading product innovation in restaurant technology. Drive impactful solutions, enhance user experiences, and collaborate closely with restaurant teams to scale our in-store off...
4 days ago
Staff Engineer, Application Security (Remote, US)
$170K - $220K *
Oversee and enhance security strategies across applications, cloud, and AI systems. Lead initiatives to mitigate risks, improve security architecture, and foster a culture of security within engineeri...
Yesterday
$125K - $150K *
Transform product strategy by leading impactful initiatives that enhance user experience and drive growth. Collaborate with cross-functional teams to deliver innovative solutions that delight customer...
1 week ago
$135K - $160K *
Optimize backend systems for a financial platform, integrating AI features and ensuring reliability across multiple regions. Collaborate with global teams to enhance product capabilities and maintain...
1 week ago
Software Engineer - Crypto Data Foundations
$152K - $179K *
Drive the development of distributed systems for real-time blockchain data ingestion and indexing, owning services from design to production while enhancing performance and reliability across the plat...
2 weeks ago
Senior Full-Stack Engineer (AI-Native)
$110K - $130K *
Optimize end-to-end project delivery by developing customer-facing products and internal tools. Collaborate with stakeholders to rapidly turn needs into functional solutions, leveraging AI and modern...
3 weeks ago
$70K - $100K *
Engage in the development of automated testing frameworks to ensure the quality and reliability of business systems. Collaborate with cross-functional teams to create effective test strategies and dri...
Reposted 4 days ago
$87K - $135K *
Drive your career forward by leading systems engineering for a cloud-based enterprise system. Engage in architecture development, integration, and modernization efforts while ensuring security and ope...
2 weeks ago
$130K - $241K *
Join a team that's redefining product management by driving AI-first digital solutions. Collaborate with diverse experts to transform strategic goals into impactful customer experiences, ensuring succ...
1 week ago
$130K - $241K *
Unlock potential by leading innovative digital product strategies that enhance customer experiences. Collaborate with diverse teams to drive AI-first solutions, ensuring successful execution from idea...
1 week ago
$130K - $192K *
Join a team that's implementing robust security controls across multiple brands, safeguarding employees and enhancing productivity through automation and secure practices. Collaborate globally while l...
Reposted 2 weeks ago
$120K - $145K *
Join a team that's redefining product management by leading cross-product initiatives and shared services. Collaborate with diverse teams to drive innovation, enhance platform capabilities, and delive...
1 week ago
Director, Software Engineering - Platform Development
$150K - $180K *
Join a dynamic team to lead the development of innovative Microsoft-based platforms, driving modernization and AI integration while ensuring robust, scalable, and secure solutions in a highly regulate...
2 weeks ago
$110K - $130K *
Inspire and elevate design excellence as you lead a talented team, setting and maintaining visual standards, driving innovative campaigns, and partnering cross-functionally to advance Dandy's brand an...
Reposted 1 week ago
$100K - $125K *
Drive AI-powered product initiatives from strategy to execution, collaborating with engineering and design to create customer-centric solutions that enhance productivity and engagement while prioritiz...
Reposted 4 days ago
Senior Manager, Solutions Engineering, MSSP
$232K - $319K *
Accelerate progress at the forefront of cybersecurity by leading a dynamic team of Solutions Engineers. Drive partner engagement, foster relationships, and execute strategic initiatives to enhance per...
2 weeks ago
$125K - $150K *
Pioneer global payroll operations, ensuring compliance and accuracy across multiple regions. Lead payroll processes and provide exceptional support as you contribute to the team’s expansion and effici...
Reposted 2 weeks ago
Senior Manager, GTM Business Planning
$120K - $145K *
Accelerate progress at a leading tech firm by driving go-to-market planning and operational execution. Lead strategic initiatives, manage forecasting, and enhance cross-functional alignment to support...
Yesterday
Senior Outbound Product Manager
$149K - $240K *
Unlock potential by driving go-to-market strategies for innovative AI products. Collaborate across teams to translate technical capabilities into compelling narratives, ensuring customer success and m...
2 weeks ago
Senior Full Stack Java Engineer - Workforce Management (WFM)
$120K - $145K *
Innovate enterprise-scale solutions for workforce management, leveraging Java, Spring Boot, React, and Node.js. Collaborate across teams to enhance forecasting, scheduling, and operational reporting i...
6 days ago
Senior Full Stack Java Engineer - Workforce Management (WFM)
$120K - $145K *
Drive your career with a Senior Full Stack Engineer role focused on building enterprise-scale workforce management solutions. Collaborate across teams to deliver scalable applications using Java, Spri...
3 weeks ago
Staff Machine Learning Engineer, Retrieval & Targeting
$230K - $322K *
Grow your career with a leading ML team focused on enhancing ad retrieval systems. Drive technical direction, develop innovative models, and collaborate across teams to optimize user experience and ad...
1 week ago
MQ-25 Vehicle Management System (VMS) Software Lead Engineer
$198K - $267K *
Unlock potential by leading the development of complex software systems for cutting-edge unmanned aircraft. Collaborate with a team of engineers to create real-time embedded solutions that enhance ope...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.