Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Elevate automation reliability by optimizing robotic systems in logistics. Drive performance, minimize downtime, and enhance operational efficiency through proactive maintenance and continuous improve...

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Drive impactful software solutions by embedding with clients, transforming ambiguous needs into deployable features across secure environments. Collaborate closely with users and stakeholders to deliv...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$107K - $130K *

Engage in developing and maintaining scalable applications that meet business needs. Collaborate across teams, troubleshoot issues, and mentor staff while delivering quality code and documentation in...

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$115K - $145K *

Elevate your career by designing and optimizing data pipelines that empower analytics and AI solutions. Collaborate with cross-functional teams to ensure data integrity and governance while mentoring...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$225K - $265K *

Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $135K *

Drive the evolution of critical DNS infrastructure, ensuring operational excellence, collaborating across teams, and enhancing production services through automation and API development...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $183K *

Innovate the future of healthcare technology by developing scalable applications that streamline specialty prescriptions. Collaborate with a skilled team to enhance user experience and drive efficienc...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Drive the development and deployment of a cutting-edge control plane for identity and credential management, ensuring reliability and security in customer-hosted environments while collaborating with...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining enterprise data management by leading cross-functional initiatives, ensuring data reliability, and driving strategic insights through advanced program management and tech...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$77K - $135K *

Grow your career with us by developing high-quality software solutions as part of a dynamic team. Collaborate on complex projects, enhance your skills, and contribute to innovative software developmen...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $153K *

Engineer and deploy secure AI-driven applications and automation solutions, enhancing operational efficiency and collaboration across teams. Leverage Generative AI and cloud technologies to solve comp...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Solve complex technical challenges in embedded systems and real-time software. Collaborate with global teams to enhance IoT devices and applications, ensuring successful implementation and operation o...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Unlock potential by enhancing application security across web apps and APIs. Collaborate with engineering teams to assess risks, conduct reviews, and drive secure software practices throughout the dev...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Reimagine cloud infrastructure as you build and operate scalable systems that empower product teams. Ensure reliability and speed in a dynamic environment, supporting enterprise-scale solutions for Fo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$224K - $356K *

Transform AI inference by leading the development of advanced GPU-accelerated software, driving feature innovation, and enhancing customer adoption in a collaborative open-source environment...

RemoteRemote

Reposted today

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$107K - $195K *

Drive the evolution of critical software applications by leading design, development, and integration efforts. Collaborate with cross-functional teams to solve complex engineering challenges while men...

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Innovate and drive AI agent development for clinical trial platforms, integrating LLMs through the .NET stack. Engage in hands-on engineering to deliver end-to-end AI features, enhancing patient-centr...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive your career with impactful first-line support for flight simulator software, troubleshooting hardware, and collaborating with cross-functional teams to enhance customer experience and resolve te...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$179K - $224K *

Join a team that's dedicated to delivering high-quality member-facing systems. As an Engineering Manager, you'll lead a squad through the entire development lifecycle, ensuring accountability, quality...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$138K - $165K *

Empower a high-performing engineering team to enhance POS payments, driving collaboration across departments and ensuring top-notch software delivery while fostering innovation and professional growth...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team to develop and customize software solutions, leveraging your expertise in Java, AWS, and agile methodologies. Collaborate on innovative projects that meet client needs while enhanc...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $155K *

Unlock potential by driving innovative AI solutions through hands-on engineering and client collaboration. Transform complex business challenges into reliable, production-ready software while enhancin...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $155K *

Drive innovation by developing AI-driven software solutions that enhance secure application delivery. Collaborate with cross-functional teams to tackle complex challenges and shape the future of softw...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Champion the management of mainframe outsourcing, ensuring optimal performance and vendor accountability while providing technical leadership and support for mainframe technologies across the organiza...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$238K - $280K *

Lead the charge in developing autonomous attack workflows for external surfaces, leveraging your expertise to enhance reconnaissance capabilities and mentor engineers while driving strategic technical...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.