Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Automation Reliability & Sustaining Operations Engineer
$110K - $130K *
Elevate automation reliability by optimizing robotic systems in logistics. Drive performance, minimize downtime, and enhance operational efficiency through proactive maintenance and continuous improve...
3 weeks ago
Forward Deployed Full Stack Engineer (Active Secret Clearance)
$120K - $145K *
Drive impactful software solutions by embedding with clients, transforming ambiguous needs into deployable features across secure environments. Collaborate closely with users and stakeholders to deliv...
Reposted 4 days ago
Senior Software Engineer, Enablement team (Shipyard)
$107K - $130K *
Engage in developing and maintaining scalable applications that meet business needs. Collaborate across teams, troubleshoot issues, and mentor staff while delivering quality code and documentation in...
1 week ago
$115K - $145K *
Elevate your career by designing and optimizing data pipelines that empower analytics and AI solutions. Collaborate with cross-functional teams to ensure data integrity and governance while mentoring...
Yesterday
$225K - $265K *
Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...
1 week ago
$125K - $135K *
Drive the evolution of critical DNS infrastructure, ensuring operational excellence, collaborating across teams, and enhancing production services through automation and API development...
Reposted 6 days ago
Specialist, Software Engineering
$110K - $183K *
Innovate the future of healthcare technology by developing scalable applications that streamline specialty prescriptions. Collaborate with a skilled team to enhance user experience and drive efficienc...
2 weeks ago
Software Engineer, Infrastructure
$135K - $160K *
Drive the development and deployment of a cutting-edge control plane for identity and credential management, ensuring reliability and security in customer-hosted environments while collaborating with...
1 week ago
Sr Technical Program Manager, Data
$120K - $145K *
Join a team that's redefining enterprise data management by leading cross-functional initiatives, ensuring data reliability, and driving strategic insights through advanced program management and tech...
Today
$77K - $135K *
Grow your career with us by developing high-quality software solutions as part of a dynamic team. Collaborate on complex projects, enhance your skills, and contribute to innovative software developmen...
1 week ago
$90K - $153K *
Engineer and deploy secure AI-driven applications and automation solutions, enhancing operational efficiency and collaboration across teams. Leverage Generative AI and cloud technologies to solve comp...
3 weeks ago
Senior Embedded (Linux & RTOS) Engineer
$120K - $145K *
Solve complex technical challenges in embedded systems and real-time software. Collaborate with global teams to enhance IoT devices and applications, ensuring successful implementation and operation o...
Today
Senior Application Security Engineer
$125K - $150K *
Unlock potential by enhancing application security across web apps and APIs. Collaborate with engineering teams to assess risks, conduct reviews, and drive secure software practices throughout the dev...
3 weeks ago
Senior Staff Platform Engineer
$135K - $160K *
Reimagine cloud infrastructure as you build and operate scalable systems that empower product teams. Ensure reliability and speed in a dynamic environment, supporting enterprise-scale solutions for Fo...
1 week ago
Senior System Software Engineer - Dynamo-Triton Inference Server
$224K - $356K *
Transform AI inference by leading the development of advanced GPU-accelerated software, driving feature innovation, and enhancing customer adoption in a collaborative open-source environment...
Reposted today
$107K - $195K *
Drive the evolution of critical software applications by leading design, development, and integration efforts. Collaborate with cross-functional teams to solve complex engineering challenges while men...
2 weeks ago
Software Engineer - AI Accelerated Development
$110K - $130K *
Innovate and drive AI agent development for clinical trial platforms, integrating LLMs through the .NET stack. Engage in hands-on engineering to deliver end-to-end AI features, enhancing patient-centr...
Reposted 3 weeks ago
$80K - $95K *
Drive your career with impactful first-line support for flight simulator software, troubleshooting hardware, and collaborating with cross-functional teams to enhance customer experience and resolve te...
Reposted 1 week ago
Engineering Manager - Member Experience
$179K - $224K *
Join a team that's dedicated to delivering high-quality member-facing systems. As an Engineering Manager, you'll lead a squad through the entire development lifecycle, ensuring accountability, quality...
3 weeks ago
Senior Manager, Software Engineering (Android) - POS Payments Experience
$138K - $165K *
Empower a high-performing engineering team to enhance POS payments, driving collaboration across departments and ensuring top-notch software delivery while fostering innovation and professional growth...
Today
$110K - $130K *
Join a dynamic team to develop and customize software solutions, leveraging your expertise in Java, AWS, and agile methodologies. Collaborate on innovative projects that meet client needs while enhanc...
4 weeks ago
Forward Deployed Engineer (San Francisco)
$130K - $155K *
Unlock potential by driving innovative AI solutions through hands-on engineering and client collaboration. Transform complex business challenges into reliable, production-ready software while enhancin...
Reposted 3 days ago
Senior AI Software Engineer (RD271)
$130K - $155K *
Drive innovation by developing AI-driven software solutions that enhance secure application delivery. Collaborate with cross-functional teams to tackle complex challenges and shape the future of softw...
6 days ago
$120K - $145K *
Champion the management of mainframe outsourcing, ensuring optimal performance and vendor accountability while providing technical leadership and support for mainframe technologies across the organiza...
2 weeks ago
Staff Attack Engineer, External
$238K - $280K *
Lead the charge in developing autonomous attack workflows for external surfaces, leveraging your expertise to enhance reconnaissance capabilities and mentor engineers while driving strategic technical...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.