Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$84K - $148K *

Empower database excellence by managing Software AG ADABAS environments, ensuring optimal performance, and providing 24x7 support. Collaborate with vendors and clients to resolve issues, maintain docu...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$70K - $115K *

Empower operational excellence by managing layout, design, and continuous improvement initiatives. Collaborate across teams to enhance performance, reduce costs, and drive quality improvements that im...

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$82K - $172K *

Accelerate progress at the intersection of security and cloud infrastructure, leading a team to optimize AWS environments, implement DevSecOps practices, and enhance automation for secure software del...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$244K - $409K *

Drive the development of a global SME organization, leading regional teams to enhance technical selling and product direction. Transform ambiguity into structure while mentoring leaders and collaborat...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $185K *

Champion client engagement success by overseeing RWD project delivery, ensuring operational efficiency, and maintaining strategic communication across teams to foster long-term client satisfaction and...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$211K - $248K *

Lead the charge in managing the complete ML model lifecycle, ensuring robust deployment, monitoring, and continuous improvement. Collaborate with data scientists to enhance model performance and opera...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$65K - $101K *

Empower the future of naval engineering by designing and managing advanced control systems for US Navy and Coast Guard ships. Collaborate in a dynamic environment to enhance machinery control moderniz...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Join a team that's revolutionizing electrical design and integration by providing high-level expertise throughout the entire product lifecycle. Collaborate on innovative solutions and mentor junior en...

Reposted yesterday

  •   8 - 10 years exp.  •   Staffing

$135K - $196K *

Unlock potential by shaping the demo experience through innovative tooling and infrastructure. Collaborate across teams to enhance product communication and drive secure access solutions, all while le...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$230K - $290K *

Pioneer the future of checkout experiences by leading frontend engineering initiatives. Collaborate across teams to set technical strategies, enhance operational processes, and foster a culture of qua...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$77K - $118K *

Transform network operations by designing and implementing automation solutions that enhance reliability and efficiency across multi-vendor infrastructures, utilizing advanced technologies like Python...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Elevate your career by building and deploying ML and GenAI components for asset onboarding and diagnostics, enhancing automation and intelligent solutions in a dynamic, collaborative environment...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$68K - $143K *

Analyze and reengineer business processes to enhance operational efficiency, collaborating with stakeholders to ensure alignment with strategic goals and regulatory requirements while supporting syste...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$118K - $217K *

Unlock potential by developing cutting-edge rendering solutions for a major video game. Collaborate with engineers and artists to enhance visual fidelity and optimize performance in a large-scale, ope...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Media

$85K - $130K *

Champion innovative control systems for industrial solutions, leading design and development projects. Collaborate with teams to ensure products meet market demands while transitioning designs to manu...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead the design and implementation of Customer Order Management solutions, ensuring alignment with global standards while enhancing operational efficiency and stakeholder collaboration across regions...

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$150K - $240K *

Develop innovative PCB layouts and improve product designs by collaborating with cross-functional teams. Ensure high quality and compliance throughout the engineering and manufacturing process, while...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Engage with our team as a Senior Services Engineer, driving B2B integration and managed file transfer solutions. Ensure operational excellence and reliability in mission-critical systems while providi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $140K *

Empower progress at the forefront of telecommunications by leveraging your structural engineering expertise to enhance infrastructure resilience and mentor emerging talent in a dynamic environment...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$90K - $110K *

Manage day-to-day infrastructure and customer support, ensuring optimal server performance, security, and incident response. Collaborate on initiatives to enhance operational security and maintain doc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$163K - $375K *

Pioneer the discipline of Code Archaeology by owning methodologies, asset portfolios, and technical leadership. Drive evidence-first discovery, manage tooling, and represent the technical voice in cli...

1 week ago

  •   11 - 15 years exp.  •   Business Services

$150K - $375K *

Lead the charge in transforming enterprise software engineering through innovative Code Archaeology methodologies, asset portfolio ownership, and technical thought leadership, ensuring impactful moder...

1 week ago

  •   11 - 15 years exp.  •   Business Services

$169K - $254K *

Lead and optimize the Solutions Engineering team in the Healthcare sector, focusing on technical sales and strategic planning. Drive team performance, manage recruitment, and ensure alignment with com...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$89K - $198K *

Drive innovative software solutions by leading architecture and development efforts, collaborating with stakeholders, and leveraging modern technologies to enhance business processes and deliver high...

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in managing and optimizing cloud infrastructure across multiple platforms. Collaborate with teams to enhance product reliability and streamline operations while ensuring security and c...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.