Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$120K - $185K *

Transform the future of engineering design by leading diverse teams to deliver high-quality electrical engineering solutions. Drive project success through strategic oversight, mentoring, and adherenc...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$110K - $183K *

Innovate the future of healthcare technology by developing scalable applications that streamline specialty prescriptions. Collaborate with a skilled team to enhance user experience and drive efficienc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$133K - $209K *

Join a dynamic IT team as you safeguard cloud infrastructure, enhance security measures, and lead incident response efforts. Your expertise will drive continuous improvement and ensure robust protecti...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $105K *

Drive cloud infrastructure excellence by managing environments, automating deployments, and ensuring security. Collaborate on cloud migrations and capacity planning while producing essential documenta...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$80K - $128K *

Develop engaging web-based training content and tools, ensuring accessibility and compliance. Collaborate on UI enhancements and create metrics dashboards to track user adoption for a federal data int...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$134K - $179K *

Shape the future of energy management by leading complex EaaS projects, optimizing system performance, and mentoring technical teams in a collaborative environment focused on excellence and client sat...

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$180K - $200K *

Shape the future of cloud infrastructure by leading a team to design, manage, and enhance developer tools and platform products that empower users to seamlessly provision and govern their infrastructu...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's redefining application security by guiding customers through complex evaluations. Leverage your expertise in offensive security to build relationships, deliver impactful demos, and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Champion innovative solutions in a dynamic, remote environment, driving sales strategy and product development for public safety agencies. Collaborate with teams to deliver impactful presentations and...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$72K - $125K *

Join a dynamic team to design, develop, and implement software solutions that address business needs. Collaborate on agile projects, mentor junior engineers, and enhance system performance while ensur...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's redefining AI solutions by rapidly delivering innovative, client-focused engagements. Collaborate with stakeholders to architect impactful agentic solutions that drive business valu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$252K - $300K *

Unlock potential by leading the technical strategy for Data Labs, guiding engineering teams to innovate AI training solutions, and shaping the future of model evaluation and deployment in a rapidly ev...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $125K *

Join a team that's dedicated to enhancing quality in aerospace and defense. Lead quality engineering initiatives, drive compliance with AS9100 standards, and foster continuous improvement across progr...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$94K - $316K *

Engineer comprehensive production systems by integrating application, data, and AI components. Lead multidisciplinary teams to transform ambiguous requirements into robust architectures and measurable...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$94K - $316K *

Champion the future of engineering by designing and operating complex production systems. Lead multidisciplinary teams to deliver AI-native solutions, ensuring seamless integration and measurable outc...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$170K - $185K *

Champion the development of scalable data platforms, leading cross-functional initiatives and enhancing AI-assisted analytics. Collaborate with teams to drive technical direction and improve system pe...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$151K - $355K *

Drive customer success as a Senior Systems Engineer, specializing in HPE Mist solutions. Collaborate with sales teams to enhance technical strategies, lead demonstrations, and ensure seamless adoption...

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$163K - $224K *

Advance innovative backend systems for a cutting-edge experimentation platform, driving impactful decisions through large-scale data solutions in a collaborative team environment, while designing and...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Lead the design and development of innovative VG Systems, enhancing product quality and operational efficiency. Collaborate with cross-functional teams to drive technical improvements and influence st...

4 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$153K - $213K *

Take ownership of a customer-facing product area, driving strategy and execution. Collaborate cross-functionally to enhance user experience, leverage AI, and achieve key performance metrics while deli...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $117K *

Play a key role in providing advanced technical support for CNC systems, optimizing performance, and collaborating with teams to enhance automation solutions. Engage with customers and partners to res...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Transform complex data systems by designing and implementing scalable solutions that enhance analytics and drive business intelligence in a collaborative, Agile environment focused on healthcare compl...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$145K - $175K *

Transform your career by architecting secure, scalable Azure solutions that drive modern application delivery. Collaborate with diverse teams to develop automation and enhance cloud services while lev...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Champion the development of an autonomous AI platform through full-stack engineering, enhancing multi-agent systems and ensuring robust quality and safety standards across production deployments...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.